Serum TSH levels are associated with cardiovascular risk factors in overweight and obese adolescents
Abstract Objective: To investigate the relationship between serum thyrotropin (TSH), insulin resistance (IR), and cardiovascular risk factors (CRF) in a sample of overweight and obese Brazilian adolescents. Methods: A retrospective, longitudinal analysis of 199 overweight and obese pubescent adole...
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doaj-26fac5695df74fa6a8ffd68992cadb932020-11-25T00:59:14ZengElsevierJornal de Pediatria1678-478292553253810.1016/j.jped.2016.01.011S0021-75572016000600532Serum TSH levels are associated with cardiovascular risk factors in overweight and obese adolescentsLuciana Lopes de SouzaErika Paniago GuedesPatrícia Fátima dos Santos TeixeiraRodrigo Oliveira MoreiraAmelio Fernando Godoy-MatosMario VaismanAbstract Objective: To investigate the relationship between serum thyrotropin (TSH), insulin resistance (IR), and cardiovascular risk factors (CRF) in a sample of overweight and obese Brazilian adolescents. Methods: A retrospective, longitudinal analysis of 199 overweight and obese pubescent adolescents was performed. The TSH and free T4 (fT4) levels, anthropometric measurements, and laboratory test results of these patients were analyzed. Results: 27 individuals (13.56%) presented with TSH levels above the normal level (subclinical hypothyroidism [SCH]). Their waist circumference (WC) was significantly higher than those of euthyroid individuals. Serum TSH was positively correlated with the homeostasis model assessment of insulin resistance (HOMA-IR) index, triglycerides (TG) and high-density lipoprotein cholesterol (HDL-C). Using TSH and BMI as independent variables, TSH levels were shown to be independently related to HOMA-IR (p = 0.001) and TG (p = 0.007). Among euthyroid subjects, individuals with TSH values <2.5 mIU/mL exhibited statistically significant decreases in waist-to-hip ratio, HDL-C levels, and HOMA-IR scores and a tendency toward lower WC values. Conclusion: SCH in overweight and obese adolescents appears to be associated with excess weight, especially visceral weight. In euthyroid adolescents, there appears to be a direct relationship between TSH and some CRF. In conclusion, in the present sample of overweight and obese adolescents, TSH levels appear to be associated with IR and CRF.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572016000600532&lng=en&tlng=enSubclinical hypothyroidismAdolescentsObesityOverweightCardiovascular risk factors |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Luciana Lopes de Souza Erika Paniago Guedes Patrícia Fátima dos Santos Teixeira Rodrigo Oliveira Moreira Amelio Fernando Godoy-Matos Mario Vaisman |
spellingShingle |
Luciana Lopes de Souza Erika Paniago Guedes Patrícia Fátima dos Santos Teixeira Rodrigo Oliveira Moreira Amelio Fernando Godoy-Matos Mario Vaisman Serum TSH levels are associated with cardiovascular risk factors in overweight and obese adolescents Jornal de Pediatria Subclinical hypothyroidism Adolescents Obesity Overweight Cardiovascular risk factors |
author_facet |
Luciana Lopes de Souza Erika Paniago Guedes Patrícia Fátima dos Santos Teixeira Rodrigo Oliveira Moreira Amelio Fernando Godoy-Matos Mario Vaisman |
author_sort |
Luciana Lopes de Souza |
title |
Serum TSH levels are associated with cardiovascular risk factors in overweight and obese adolescents |
title_short |
Serum TSH levels are associated with cardiovascular risk factors in overweight and obese adolescents |
title_full |
Serum TSH levels are associated with cardiovascular risk factors in overweight and obese adolescents |
title_fullStr |
Serum TSH levels are associated with cardiovascular risk factors in overweight and obese adolescents |
title_full_unstemmed |
Serum TSH levels are associated with cardiovascular risk factors in overweight and obese adolescents |
title_sort |
serum tsh levels are associated with cardiovascular risk factors in overweight and obese adolescents |
publisher |
Elsevier |
series |
Jornal de Pediatria |
issn |
1678-4782 |
description |
Abstract Objective: To investigate the relationship between serum thyrotropin (TSH), insulin resistance (IR), and cardiovascular risk factors (CRF) in a sample of overweight and obese Brazilian adolescents. Methods: A retrospective, longitudinal analysis of 199 overweight and obese pubescent adolescents was performed. The TSH and free T4 (fT4) levels, anthropometric measurements, and laboratory test results of these patients were analyzed. Results: 27 individuals (13.56%) presented with TSH levels above the normal level (subclinical hypothyroidism [SCH]). Their waist circumference (WC) was significantly higher than those of euthyroid individuals. Serum TSH was positively correlated with the homeostasis model assessment of insulin resistance (HOMA-IR) index, triglycerides (TG) and high-density lipoprotein cholesterol (HDL-C). Using TSH and BMI as independent variables, TSH levels were shown to be independently related to HOMA-IR (p = 0.001) and TG (p = 0.007). Among euthyroid subjects, individuals with TSH values <2.5 mIU/mL exhibited statistically significant decreases in waist-to-hip ratio, HDL-C levels, and HOMA-IR scores and a tendency toward lower WC values. Conclusion: SCH in overweight and obese adolescents appears to be associated with excess weight, especially visceral weight. In euthyroid adolescents, there appears to be a direct relationship between TSH and some CRF. In conclusion, in the present sample of overweight and obese adolescents, TSH levels appear to be associated with IR and CRF. |
topic |
Subclinical hypothyroidism Adolescents Obesity Overweight Cardiovascular risk factors |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572016000600532&lng=en&tlng=en |
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