Beta-amyloid production in neurons is regulated by astrocyte-derived cholesterol
The accumulation of amyloid β (Aβ) in the brain is an established feature of Alzheimer’s disease, however mechanisms that regulate Aβ accumulation are not fully understood. In a recent study, Wang et al show that Aβ accumulation in neurons is tightly regulated by cholesterol production in astrocytes...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-09-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02644-7 |
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Article |
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doaj-26fb03a1522c4f559b08f2a7931ec6562021-09-26T11:14:31ZengNature Publishing GroupCommunications Biology2399-36422021-09-01411110.1038/s42003-021-02644-7Beta-amyloid production in neurons is regulated by astrocyte-derived cholesterolKarli Montague-Cardoso0Communications BiologyThe accumulation of amyloid β (Aβ) in the brain is an established feature of Alzheimer’s disease, however mechanisms that regulate Aβ accumulation are not fully understood. In a recent study, Wang et al show that Aβ accumulation in neurons is tightly regulated by cholesterol production in astrocytes. This finding paves the way for future work that will establish whether the selective removal of Aβ by targeting this mechanism has therapeutic potential.https://doi.org/10.1038/s42003-021-02644-7 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Karli Montague-Cardoso |
| spellingShingle |
Karli Montague-Cardoso Beta-amyloid production in neurons is regulated by astrocyte-derived cholesterol Communications Biology |
| author_facet |
Karli Montague-Cardoso |
| author_sort |
Karli Montague-Cardoso |
| title |
Beta-amyloid production in neurons is regulated by astrocyte-derived cholesterol |
| title_short |
Beta-amyloid production in neurons is regulated by astrocyte-derived cholesterol |
| title_full |
Beta-amyloid production in neurons is regulated by astrocyte-derived cholesterol |
| title_fullStr |
Beta-amyloid production in neurons is regulated by astrocyte-derived cholesterol |
| title_full_unstemmed |
Beta-amyloid production in neurons is regulated by astrocyte-derived cholesterol |
| title_sort |
beta-amyloid production in neurons is regulated by astrocyte-derived cholesterol |
| publisher |
Nature Publishing Group |
| series |
Communications Biology |
| issn |
2399-3642 |
| publishDate |
2021-09-01 |
| description |
The accumulation of amyloid β (Aβ) in the brain is an established feature of Alzheimer’s disease, however mechanisms that regulate Aβ accumulation are not fully understood. In a recent study, Wang et al show that Aβ accumulation in neurons is tightly regulated by cholesterol production in astrocytes. This finding paves the way for future work that will establish whether the selective removal of Aβ by targeting this mechanism has therapeutic potential. |
| url |
https://doi.org/10.1038/s42003-021-02644-7 |
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AT karlimontaguecardoso betaamyloidproductioninneuronsisregulatedbyastrocytederivedcholesterol |
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