Comparative study of the efficacy and pharmacokinetics of reduning injection and atomization inhalation
The effects of Reduning injection and nebulized inhalation for treating upper respiratory tract infections were compared, including anti-bacterial, anti-viral, anti-inflammatory, anti-pyretic, anti-tussive, and anti-phlegm. Using chlorogenic acid, cryptochlorogenic acid, neochlorogenic acid, and gen...
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doaj-26fc419ee23147cc86f16ed1982d91fa2021-05-21T04:17:52ZengElsevierBiomedicine & Pharmacotherapy0753-33222019-10-01118Comparative study of the efficacy and pharmacokinetics of reduning injection and atomization inhalationGuangping Zhang0Yingfei Li1Tengfei Chen2Yunhang Gao3Jing Sun4Wei Yang5Ling Song6Ping Su7Meng Ma8Zhongxiu Zhang9Haijing Zhang10Yifei Yang11Han Li12Zuguang Ye13Hongping Hou14School of Life Sciences, Liaoning Provincial Key Laboratory of Biotechnology and Drug Discovery, Liaoning Normal University, Dalian, 116029, China; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China; Corresponding authors.Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China; Corresponding authors.The effects of Reduning injection and nebulized inhalation for treating upper respiratory tract infections were compared, including anti-bacterial, anti-viral, anti-inflammatory, anti-pyretic, anti-tussive, and anti-phlegm. Using chlorogenic acid, cryptochlorogenic acid, neochlorogenic acid, and geniposide as the index components, the pharmacokinetics and tissue distributions were compared. Influenza virus PR8-infected mice in the Reduning groups showed significantly reduced mortality and prolonged survival time. The white blood cell count was significantly reduced in the 20- and 10-min groups. Inhalation significantly decreased the temperature from 2 h in the 20- and 10-min groups. Inhalation significantly reduced the cough rate but not cough latency. Phenol red excretion was significantly increased in all Reduning groups. The elimination half-life of geniposide after inhalation in male and female rats was 2.05–5.28 and 4.03–10.4 h, respectively, which was much greater than after injection. Regarding tissue distribution, the injection dose (2 mL/kg) was 50 times the inhalation dose, and maximum serum concentration (Cmax) and AUCINF_obs of the four components in the trachea and lung were 0.95–11.1 and 0.59–4.36 times the inhalation values, respectively. Plasma Cmax and AUCINF_obs were 160–637 and 22.7–180 times the inhalation values, respectively. Atomized Reduning dose was equivalent to 1/90 of the mouse injection dose, and the effects of inhalation were similar or superior to those of injections. Atomization inhalation is targeted to the lungs, so systemic drug exposure was greatly reduced and lung concentration was high, which may increase the efficacy and reduce the safety risks associated with injections.http://www.sciencedirect.com/science/article/pii/S075333221932582XReduning inhalation solutionReduning injectionPharmacodynamicsPharmacokinetics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Guangping Zhang Yingfei Li Tengfei Chen Yunhang Gao Jing Sun Wei Yang Ling Song Ping Su Meng Ma Zhongxiu Zhang Haijing Zhang Yifei Yang Han Li Zuguang Ye Hongping Hou |
spellingShingle |
Guangping Zhang Yingfei Li Tengfei Chen Yunhang Gao Jing Sun Wei Yang Ling Song Ping Su Meng Ma Zhongxiu Zhang Haijing Zhang Yifei Yang Han Li Zuguang Ye Hongping Hou Comparative study of the efficacy and pharmacokinetics of reduning injection and atomization inhalation Biomedicine & Pharmacotherapy Reduning inhalation solution Reduning injection Pharmacodynamics Pharmacokinetics |
author_facet |
Guangping Zhang Yingfei Li Tengfei Chen Yunhang Gao Jing Sun Wei Yang Ling Song Ping Su Meng Ma Zhongxiu Zhang Haijing Zhang Yifei Yang Han Li Zuguang Ye Hongping Hou |
author_sort |
Guangping Zhang |
title |
Comparative study of the efficacy and pharmacokinetics of reduning injection and atomization inhalation |
title_short |
Comparative study of the efficacy and pharmacokinetics of reduning injection and atomization inhalation |
title_full |
Comparative study of the efficacy and pharmacokinetics of reduning injection and atomization inhalation |
title_fullStr |
Comparative study of the efficacy and pharmacokinetics of reduning injection and atomization inhalation |
title_full_unstemmed |
Comparative study of the efficacy and pharmacokinetics of reduning injection and atomization inhalation |
title_sort |
comparative study of the efficacy and pharmacokinetics of reduning injection and atomization inhalation |
publisher |
Elsevier |
series |
Biomedicine & Pharmacotherapy |
issn |
0753-3322 |
publishDate |
2019-10-01 |
description |
The effects of Reduning injection and nebulized inhalation for treating upper respiratory tract infections were compared, including anti-bacterial, anti-viral, anti-inflammatory, anti-pyretic, anti-tussive, and anti-phlegm. Using chlorogenic acid, cryptochlorogenic acid, neochlorogenic acid, and geniposide as the index components, the pharmacokinetics and tissue distributions were compared. Influenza virus PR8-infected mice in the Reduning groups showed significantly reduced mortality and prolonged survival time. The white blood cell count was significantly reduced in the 20- and 10-min groups. Inhalation significantly decreased the temperature from 2 h in the 20- and 10-min groups. Inhalation significantly reduced the cough rate but not cough latency. Phenol red excretion was significantly increased in all Reduning groups. The elimination half-life of geniposide after inhalation in male and female rats was 2.05–5.28 and 4.03–10.4 h, respectively, which was much greater than after injection. Regarding tissue distribution, the injection dose (2 mL/kg) was 50 times the inhalation dose, and maximum serum concentration (Cmax) and AUCINF_obs of the four components in the trachea and lung were 0.95–11.1 and 0.59–4.36 times the inhalation values, respectively. Plasma Cmax and AUCINF_obs were 160–637 and 22.7–180 times the inhalation values, respectively. Atomized Reduning dose was equivalent to 1/90 of the mouse injection dose, and the effects of inhalation were similar or superior to those of injections. Atomization inhalation is targeted to the lungs, so systemic drug exposure was greatly reduced and lung concentration was high, which may increase the efficacy and reduce the safety risks associated with injections. |
topic |
Reduning inhalation solution Reduning injection Pharmacodynamics Pharmacokinetics |
url |
http://www.sciencedirect.com/science/article/pii/S075333221932582X |
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