Mutational spectrum and prognosis in NRAS-mutated acute myeloid leukemia

Mutational spectrum and prognosis in NRAS-mutated acute myeloid leukemia

Abstract The mutational spectrum and prognostic factors of NRAS-mutated (NRAS mut) acute myeloid leukemia (AML) are largely unknown. We performed next-generation sequencing (NGS) in 1,149 cases of de novo AML and discovered 152 NRAS mut AML (13%). Of the 152 NRAS mut AML, 89% had at least one compan...

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Bibliographic Details
Main Authors: Shujuan Wang, Zhenzhen Wu, Tao Li, Yafei Li, Weiqiong Wang, Qianqian Hao, Xinsheng Xie, Dingming Wan, Zhongxing Jiang, Chong Wang, Yanfang Liu
Format: Article
Language:English
Published: Nature Publishing Group 2020-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-69194-6

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https://doi.org/10.1038/s41598-020-69194-6

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