Mutational spectrum and prognosis in NRAS-mutated acute myeloid leukemia
Abstract The mutational spectrum and prognostic factors of NRAS-mutated (NRAS mut) acute myeloid leukemia (AML) are largely unknown. We performed next-generation sequencing (NGS) in 1,149 cases of de novo AML and discovered 152 NRAS mut AML (13%). Of the 152 NRAS mut AML, 89% had at least one compan...
Main Authors: | Shujuan Wang, Zhenzhen Wu, Tao Li, Yafei Li, Weiqiong Wang, Qianqian Hao, Xinsheng Xie, Dingming Wan, Zhongxing Jiang, Chong Wang, Yanfang Liu |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2020-07-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-020-69194-6 |
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