Cognitive Performance Following Ingestion of Glucose–Fructose Sweeteners That Impart Different Postprandial Glycaemic Responses: A Randomised Control Trial
We aimed to investigate the isolated effect of glycaemia on cognitive test performance by using beverages sweetened with two different glucose−fructose disaccharides, sucrose and isomaltulose. In a randomised crossover design, 70 healthy adults received a low-glycaemic-index (GI) isomaltul...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-11-01
|
Series: | Nutrients |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6643/11/11/2647 |
id |
doaj-2716b2c265aa41fcaae90ccc24f74ddc |
---|---|
record_format |
Article |
spelling |
doaj-2716b2c265aa41fcaae90ccc24f74ddc2020-11-24T21:33:51ZengMDPI AGNutrients2072-66432019-11-011111264710.3390/nu11112647nu11112647Cognitive Performance Following Ingestion of Glucose–Fructose Sweeteners That Impart Different Postprandial Glycaemic Responses: A Randomised Control TrialCeleste Keesing0Brianna Mills1Charlene Rapsey2Jillian Haszard3Bernard Venn4Department of Human Nutrition, University of Otago, PO Box 56, Dunedin 9054, New ZealandDepartment of Human Nutrition, University of Otago, PO Box 56, Dunedin 9054, New ZealandDepartment of Psychological Medicine, Otago Medical School, University of Otago, PO Box 56, Dunedin 9054, New ZealandDepartment of Human Nutrition, University of Otago, PO Box 56, Dunedin 9054, New ZealandDepartment of Human Nutrition, University of Otago, PO Box 56, Dunedin 9054, New ZealandWe aimed to investigate the isolated effect of glycaemia on cognitive test performance by using beverages sweetened with two different glucose−fructose disaccharides, sucrose and isomaltulose. In a randomised crossover design, 70 healthy adults received a low-glycaemic-index (GI) isomaltulose and sucralose beverage (GI 32) and a high-GI sucrose beverage (GI 65) on two occasions that were separated by two weeks. Following beverage ingestion, declarative memory and immediate word recall were examined at 30, 80 and 130 min. At 140 min, executive function was tested. To confirm that the glycaemic response of the test beverages matched published GI estimates, a subsample (<i>n</i> = 12) of the cognitive testing population (<i>n</i> = 70) underwent glycaemic response testing on different test days. A significantly lower value of mean (95% CI) blood glucose concentration incremental area under the curve (iAUC) was found for isomaltulose, in comparison to the blood glucose concentration iAUC value for sucrose, the difference corresponding to −44 mmol/L∙min (−70, −18), <i>p</i> = 0.003. The mean (95% CI) difference in numbers of correct answers or words recalled between beverages at 30, 80 and 130 min were 0.1 (−0.2, 0.5), −0.3 (−0.8, 0.2) and 0.0 (−0.5, 0.5) for declarative memory, and −0.5 (−1.4, 0.3), 0.4 (−0.4, 1.3) and −0.4 (−1.1, 0.4) for immediate free word recall. At 140 min, the mean difference in the trail-making test between beverages was −0.3 sec (−6.9, 6.3). None of these differences were statistically or clinically significant. In summary, cognitive performance was unaffected by different glycaemic responses to beverages during the postprandial period of 140 min.https://www.mdpi.com/2072-6643/11/11/2647glucosefructosesucroseisomaltuloseglycaemiainsulinaemiacognition |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Celeste Keesing Brianna Mills Charlene Rapsey Jillian Haszard Bernard Venn |
spellingShingle |
Celeste Keesing Brianna Mills Charlene Rapsey Jillian Haszard Bernard Venn Cognitive Performance Following Ingestion of Glucose–Fructose Sweeteners That Impart Different Postprandial Glycaemic Responses: A Randomised Control Trial Nutrients glucose fructose sucrose isomaltulose glycaemia insulinaemia cognition |
author_facet |
Celeste Keesing Brianna Mills Charlene Rapsey Jillian Haszard Bernard Venn |
author_sort |
Celeste Keesing |
title |
Cognitive Performance Following Ingestion of Glucose–Fructose Sweeteners That Impart Different Postprandial Glycaemic Responses: A Randomised Control Trial |
title_short |
Cognitive Performance Following Ingestion of Glucose–Fructose Sweeteners That Impart Different Postprandial Glycaemic Responses: A Randomised Control Trial |
title_full |
Cognitive Performance Following Ingestion of Glucose–Fructose Sweeteners That Impart Different Postprandial Glycaemic Responses: A Randomised Control Trial |
title_fullStr |
Cognitive Performance Following Ingestion of Glucose–Fructose Sweeteners That Impart Different Postprandial Glycaemic Responses: A Randomised Control Trial |
title_full_unstemmed |
Cognitive Performance Following Ingestion of Glucose–Fructose Sweeteners That Impart Different Postprandial Glycaemic Responses: A Randomised Control Trial |
title_sort |
cognitive performance following ingestion of glucose–fructose sweeteners that impart different postprandial glycaemic responses: a randomised control trial |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2019-11-01 |
description |
We aimed to investigate the isolated effect of glycaemia on cognitive test performance by using beverages sweetened with two different glucose−fructose disaccharides, sucrose and isomaltulose. In a randomised crossover design, 70 healthy adults received a low-glycaemic-index (GI) isomaltulose and sucralose beverage (GI 32) and a high-GI sucrose beverage (GI 65) on two occasions that were separated by two weeks. Following beverage ingestion, declarative memory and immediate word recall were examined at 30, 80 and 130 min. At 140 min, executive function was tested. To confirm that the glycaemic response of the test beverages matched published GI estimates, a subsample (<i>n</i> = 12) of the cognitive testing population (<i>n</i> = 70) underwent glycaemic response testing on different test days. A significantly lower value of mean (95% CI) blood glucose concentration incremental area under the curve (iAUC) was found for isomaltulose, in comparison to the blood glucose concentration iAUC value for sucrose, the difference corresponding to −44 mmol/L∙min (−70, −18), <i>p</i> = 0.003. The mean (95% CI) difference in numbers of correct answers or words recalled between beverages at 30, 80 and 130 min were 0.1 (−0.2, 0.5), −0.3 (−0.8, 0.2) and 0.0 (−0.5, 0.5) for declarative memory, and −0.5 (−1.4, 0.3), 0.4 (−0.4, 1.3) and −0.4 (−1.1, 0.4) for immediate free word recall. At 140 min, the mean difference in the trail-making test between beverages was −0.3 sec (−6.9, 6.3). None of these differences were statistically or clinically significant. In summary, cognitive performance was unaffected by different glycaemic responses to beverages during the postprandial period of 140 min. |
topic |
glucose fructose sucrose isomaltulose glycaemia insulinaemia cognition |
url |
https://www.mdpi.com/2072-6643/11/11/2647 |
work_keys_str_mv |
AT celestekeesing cognitiveperformancefollowingingestionofglucosefructosesweetenersthatimpartdifferentpostprandialglycaemicresponsesarandomisedcontroltrial AT briannamills cognitiveperformancefollowingingestionofglucosefructosesweetenersthatimpartdifferentpostprandialglycaemicresponsesarandomisedcontroltrial AT charlenerapsey cognitiveperformancefollowingingestionofglucosefructosesweetenersthatimpartdifferentpostprandialglycaemicresponsesarandomisedcontroltrial AT jillianhaszard cognitiveperformancefollowingingestionofglucosefructosesweetenersthatimpartdifferentpostprandialglycaemicresponsesarandomisedcontroltrial AT bernardvenn cognitiveperformancefollowingingestionofglucosefructosesweetenersthatimpartdifferentpostprandialglycaemicresponsesarandomisedcontroltrial |
_version_ |
1725951638453092352 |