Association of Cancer Stem Cell Radio-Resistance Under Ultra-High Dose Rate FLASH Irradiation With Lysosome-Mediated Autophagy

Association of Cancer Stem Cell Radio-Resistance Under Ultra-High Dose Rate FLASH Irradiation With Lysosome-Mediated Autophagy

Cancer stem cell (CSC) is thought to be the major cause of radio-resistance and relapse post radiotherapy (RT). Recently ultra-high dose rate “FLASH-RT” evokes great interest for its decreasing normal tissue damages while maintaining tumor responses compared with conventional dose rate RT. However,...

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Bibliographic Details
Main Authors: Gen Yang, Chunyang Lu, Zhusong Mei, Xiaoyi Sun, Jintao Han, Jing Qian, Yulan Liang, Zhuo Pan, Defeng Kong, Shirui Xu, Zhipeng Liu, Ying Gao, Guijun Qi, Yinren Shou, Shiyou Chen, Zhengxuan Cao, Ye Zhao, Chen Lin, Yanying Zhao, Yixing Geng, Wenjun Ma, Xueqing Yan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
ultra-high dose rate irradiation
FLASH
DNA damage
lysosome
cancer stem cell
autophagy
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.672693/full

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