Cerebrospinal fluid xanthochromia after pegasparaginase hepatotoxicity in B‐cell acute lymphoblastic leukemia

Key Clinical Message Patients with B‐lineage acute lymphoblastic leukemia treated with pegasparaginase‐containing regimens can develop hepatotoxicity related to it. The systemic hyperbilirubinemia due to hepatotoxicity can lead to the development of CSF xanthochromia.

Bibliographic Details
Main Authors:	Riccardo Moia, Mariangela Greco, Paola Boggione, Maura Nicolosi, Riccardo Bruna, Andrea Patriarca, Gianluca Gaidano, Monia Lunghi
Format:	Article
Language:	English
Published:	Wiley 2020-11-01
Series:	Clinical Case Reports
Subjects:	ALL CSF xanthochromia hepatotoxicity pegasparaginase
Online Access:	https://doi.org/10.1002/ccr3.3114

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spelling	doaj-271c25f59e47466c8013b927bd5c35af2020-11-25T04:00:14ZengWileyClinical Case Reports2050-09042020-11-018112293229410.1002/ccr3.3114Cerebrospinal fluid xanthochromia after pegasparaginase hepatotoxicity in B‐cell acute lymphoblastic leukemiaRiccardo Moia0Mariangela Greco1Paola Boggione2Maura Nicolosi3Riccardo Bruna4Andrea Patriarca5Gianluca Gaidano6Monia Lunghi7Division of Hematology Department of Translational Medicine Università del Piemonte Orientale Novara ItalyDivision of Hematology Department of Translational Medicine Università del Piemonte Orientale Novara ItalyDivision of Hematology Department of Translational Medicine Università del Piemonte Orientale Novara ItalyDivision of Hematology Department of Translational Medicine Università del Piemonte Orientale Novara ItalyDivision of Hematology Department of Translational Medicine Università del Piemonte Orientale Novara ItalyDivision of Hematology Department of Translational Medicine Università del Piemonte Orientale Novara ItalyDivision of Hematology Department of Translational Medicine Università del Piemonte Orientale Novara ItalyDivision of Hematology Department of Translational Medicine Università del Piemonte Orientale Novara ItalyKey Clinical Message Patients with B‐lineage acute lymphoblastic leukemia treated with pegasparaginase‐containing regimens can develop hepatotoxicity related to it. The systemic hyperbilirubinemia due to hepatotoxicity can lead to the development of CSF xanthochromia.https://doi.org/10.1002/ccr3.3114ALLCSF xanthochromiahepatotoxicitypegasparaginase
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Riccardo Moia Mariangela Greco Paola Boggione Maura Nicolosi Riccardo Bruna Andrea Patriarca Gianluca Gaidano Monia Lunghi
spellingShingle	Riccardo Moia Mariangela Greco Paola Boggione Maura Nicolosi Riccardo Bruna Andrea Patriarca Gianluca Gaidano Monia Lunghi Cerebrospinal fluid xanthochromia after pegasparaginase hepatotoxicity in B‐cell acute lymphoblastic leukemia Clinical Case Reports ALL CSF xanthochromia hepatotoxicity pegasparaginase
author_facet	Riccardo Moia Mariangela Greco Paola Boggione Maura Nicolosi Riccardo Bruna Andrea Patriarca Gianluca Gaidano Monia Lunghi
author_sort	Riccardo Moia
title	Cerebrospinal fluid xanthochromia after pegasparaginase hepatotoxicity in B‐cell acute lymphoblastic leukemia
title_short	Cerebrospinal fluid xanthochromia after pegasparaginase hepatotoxicity in B‐cell acute lymphoblastic leukemia
title_full	Cerebrospinal fluid xanthochromia after pegasparaginase hepatotoxicity in B‐cell acute lymphoblastic leukemia
title_fullStr	Cerebrospinal fluid xanthochromia after pegasparaginase hepatotoxicity in B‐cell acute lymphoblastic leukemia
title_full_unstemmed	Cerebrospinal fluid xanthochromia after pegasparaginase hepatotoxicity in B‐cell acute lymphoblastic leukemia
title_sort	cerebrospinal fluid xanthochromia after pegasparaginase hepatotoxicity in b‐cell acute lymphoblastic leukemia
publisher	Wiley
series	Clinical Case Reports
issn	2050-0904
publishDate	2020-11-01
description	Key Clinical Message Patients with B‐lineage acute lymphoblastic leukemia treated with pegasparaginase‐containing regimens can develop hepatotoxicity related to it. The systemic hyperbilirubinemia due to hepatotoxicity can lead to the development of CSF xanthochromia.
topic	ALL CSF xanthochromia hepatotoxicity pegasparaginase
url	https://doi.org/10.1002/ccr3.3114
work_keys_str_mv	AT riccardomoia cerebrospinalfluidxanthochromiaafterpegasparaginasehepatotoxicityinbcellacutelymphoblasticleukemia AT mariangelagreco cerebrospinalfluidxanthochromiaafterpegasparaginasehepatotoxicityinbcellacutelymphoblasticleukemia AT paolaboggione cerebrospinalfluidxanthochromiaafterpegasparaginasehepatotoxicityinbcellacutelymphoblasticleukemia AT mauranicolosi cerebrospinalfluidxanthochromiaafterpegasparaginasehepatotoxicityinbcellacutelymphoblasticleukemia AT riccardobruna cerebrospinalfluidxanthochromiaafterpegasparaginasehepatotoxicityinbcellacutelymphoblasticleukemia AT andreapatriarca cerebrospinalfluidxanthochromiaafterpegasparaginasehepatotoxicityinbcellacutelymphoblasticleukemia AT gianlucagaidano cerebrospinalfluidxanthochromiaafterpegasparaginasehepatotoxicityinbcellacutelymphoblasticleukemia AT monialunghi cerebrospinalfluidxanthochromiaafterpegasparaginasehepatotoxicityinbcellacutelymphoblasticleukemia
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Cerebrospinal fluid xanthochromia after pegasparaginase hepatotoxicity in B‐cell acute lymphoblastic leukemia

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