The Therapeutic Potential of Wogonin Observed in Preclinical Studies
Wogonin is a flavonoid found in different plants such as roots of Scutellaria baicalensis Georgi distributed mainly in Asia and Europe. Dried root extracts of S. baicalensis with high content of wogonin, popularly known as “Huang-Qin” or Chinese or baical skullcap, have been used for long time in tr...
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2021-01-01
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Online Access: | http://dx.doi.org/10.1155/2021/9935451 |
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doaj-273087a841224154a8892557e5a0274b2021-06-28T01:51:18ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-42882021-01-01202110.1155/2021/9935451The Therapeutic Potential of Wogonin Observed in Preclinical StudiesJavad Sharifi-Rad0Jesús Herrera-Bravo1Luis A. Salazar2Shabnum Shaheen3Seyed Abdulmajid Ayatollahi4Farzad Kobarfard5Muhammad Imran6Ali Imran7Luísa Custódio8María Dolores López9Mauricio Schoebitz10Miquel Martorell11Manoj Kumar12Hafiz Ansar Rasul Suleria13William C. Cho14Phytochemistry Research CenterDepartamento de Ciencias BásicasCenter of Molecular Biology and PharmacogeneticsDepartment of Plant SciencesPhytochemistry Research CenterPhytochemistry Research CenterUniversity Institute of Diet and Nutritional SciencesDepartment of Food ScienceCentre of Marine SciencesDepartment of Plant ProductionDepartamento de Suelos y Recursos NaturalesDepartment of Nutrition and DieteticsChemical and Biochemical Processing DivisionDepartment of Agriculture and Food SystemsDepartment of Clinical OncologyWogonin is a flavonoid found in different plants such as roots of Scutellaria baicalensis Georgi distributed mainly in Asia and Europe. Dried root extracts of S. baicalensis with high content of wogonin, popularly known as “Huang-Qin” or Chinese or baical skullcap, have been used for long time in traditional Chinese medicine. Several health benefits are attributed to wogonin and derivatives showing anti-inflammatory, antiviral, anticancer, and antioxidant effects and more recently antineurodegenerative properties. Preclinical pharmacological activities of wogonin against diverse types of cancer such as breast, colorectal, and human gastric cancer will be presented in this review. In addition, studies on oxidative stress and bioavailability of wogonin will be discussed together with antineurodegenerative potential with special focus on Alzheimer’s disease. Outcomes extracted from the last preclinical studies related to therapeutic applications of wogonin will be commented and updated in this review. The scientific evidence collected in this review aims to encourage transfer of the preclinical evidence of wogonin to new clinical studies.http://dx.doi.org/10.1155/2021/9935451 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Javad Sharifi-Rad Jesús Herrera-Bravo Luis A. Salazar Shabnum Shaheen Seyed Abdulmajid Ayatollahi Farzad Kobarfard Muhammad Imran Ali Imran Luísa Custódio María Dolores López Mauricio Schoebitz Miquel Martorell Manoj Kumar Hafiz Ansar Rasul Suleria William C. Cho |
spellingShingle |
Javad Sharifi-Rad Jesús Herrera-Bravo Luis A. Salazar Shabnum Shaheen Seyed Abdulmajid Ayatollahi Farzad Kobarfard Muhammad Imran Ali Imran Luísa Custódio María Dolores López Mauricio Schoebitz Miquel Martorell Manoj Kumar Hafiz Ansar Rasul Suleria William C. Cho The Therapeutic Potential of Wogonin Observed in Preclinical Studies Evidence-Based Complementary and Alternative Medicine |
author_facet |
Javad Sharifi-Rad Jesús Herrera-Bravo Luis A. Salazar Shabnum Shaheen Seyed Abdulmajid Ayatollahi Farzad Kobarfard Muhammad Imran Ali Imran Luísa Custódio María Dolores López Mauricio Schoebitz Miquel Martorell Manoj Kumar Hafiz Ansar Rasul Suleria William C. Cho |
author_sort |
Javad Sharifi-Rad |
title |
The Therapeutic Potential of Wogonin Observed in Preclinical Studies |
title_short |
The Therapeutic Potential of Wogonin Observed in Preclinical Studies |
title_full |
The Therapeutic Potential of Wogonin Observed in Preclinical Studies |
title_fullStr |
The Therapeutic Potential of Wogonin Observed in Preclinical Studies |
title_full_unstemmed |
The Therapeutic Potential of Wogonin Observed in Preclinical Studies |
title_sort |
therapeutic potential of wogonin observed in preclinical studies |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-4288 |
publishDate |
2021-01-01 |
description |
Wogonin is a flavonoid found in different plants such as roots of Scutellaria baicalensis Georgi distributed mainly in Asia and Europe. Dried root extracts of S. baicalensis with high content of wogonin, popularly known as “Huang-Qin” or Chinese or baical skullcap, have been used for long time in traditional Chinese medicine. Several health benefits are attributed to wogonin and derivatives showing anti-inflammatory, antiviral, anticancer, and antioxidant effects and more recently antineurodegenerative properties. Preclinical pharmacological activities of wogonin against diverse types of cancer such as breast, colorectal, and human gastric cancer will be presented in this review. In addition, studies on oxidative stress and bioavailability of wogonin will be discussed together with antineurodegenerative potential with special focus on Alzheimer’s disease. Outcomes extracted from the last preclinical studies related to therapeutic applications of wogonin will be commented and updated in this review. The scientific evidence collected in this review aims to encourage transfer of the preclinical evidence of wogonin to new clinical studies. |
url |
http://dx.doi.org/10.1155/2021/9935451 |
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