A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction

A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction

ORAI1 constitutes the store-operated Ca2+ release-activated Ca2+ (CRAC) channel, but how this channel is turned off through Ca2+-dependent inactivation (CDI) remained unclear. Here the authors identify a spatially-restricted Ca2+/cAMP signaling crosstalk critical for mediating CDI which in turn regu...

Full description

Bibliographic Details
Main Authors: Xuexin Zhang, Trayambak Pathak, Ryan Yoast, Scott Emrich, Ping Xin, Robert M. Nwokonko, Martin Johnson, Shilan Wu, Céline Delierneux, Maxime Gueguinou, Nadine Hempel, James W. Putney, Donald L. Gill, Mohamed Trebak
Format: Article
Language:English
Published: Nature Publishing Group 2019-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09593-0
id doaj-273145bab6b34b6fac4674fdd0ecc38c
record_format Article
spelling doaj-273145bab6b34b6fac4674fdd0ecc38c2021-05-11T11:33:13ZengNature Publishing GroupNature Communications2041-17232019-04-0110111310.1038/s41467-019-09593-0A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT inductionXuexin Zhang0Trayambak Pathak1Ryan Yoast2Scott Emrich3Ping Xin4Robert M. Nwokonko5Martin Johnson6Shilan Wu7Céline Delierneux8Maxime Gueguinou9Nadine Hempel10James W. Putney11Donald L. Gill12Mohamed Trebak13Department of Cellular and Molecular Physiology, The Pennsylvania State University College of MedicineDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of MedicineDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of MedicineDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of MedicineDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of MedicineDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of MedicineDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of MedicineDepartment of Health and Human Services, Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of HealthDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of MedicineDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of MedicineDepartment of Pharmacology, The Pennsylvania State University College of MedicineDepartment of Health and Human Services, Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of HealthDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of MedicineDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of MedicineORAI1 constitutes the store-operated Ca2+ release-activated Ca2+ (CRAC) channel, but how this channel is turned off through Ca2+-dependent inactivation (CDI) remained unclear. Here the authors identify a spatially-restricted Ca2+/cAMP signaling crosstalk critical for mediating CDI which in turn regulates cellular Ca2+ signals and NFAT activation.https://doi.org/10.1038/s41467-019-09593-0
collection DOAJ
language English
format Article
sources DOAJ
author Xuexin Zhang
Trayambak Pathak
Ryan Yoast
Scott Emrich
Ping Xin
Robert M. Nwokonko
Martin Johnson
Shilan Wu
Céline Delierneux
Maxime Gueguinou
Nadine Hempel
James W. Putney
Donald L. Gill
Mohamed Trebak
spellingShingle Xuexin Zhang
Trayambak Pathak
Ryan Yoast
Scott Emrich
Ping Xin
Robert M. Nwokonko
Martin Johnson
Shilan Wu
Céline Delierneux
Maxime Gueguinou
Nadine Hempel
James W. Putney
Donald L. Gill
Mohamed Trebak
A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction
Nature Communications
author_facet Xuexin Zhang
Trayambak Pathak
Ryan Yoast
Scott Emrich
Ping Xin
Robert M. Nwokonko
Martin Johnson
Shilan Wu
Céline Delierneux
Maxime Gueguinou
Nadine Hempel
James W. Putney
Donald L. Gill
Mohamed Trebak
author_sort Xuexin Zhang
title A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction
title_short A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction
title_full A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction
title_fullStr A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction
title_full_unstemmed A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction
title_sort calcium/camp signaling loop at the orai1 mouth drives channel inactivation to shape nfat induction
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-04-01
description ORAI1 constitutes the store-operated Ca2+ release-activated Ca2+ (CRAC) channel, but how this channel is turned off through Ca2+-dependent inactivation (CDI) remained unclear. Here the authors identify a spatially-restricted Ca2+/cAMP signaling crosstalk critical for mediating CDI which in turn regulates cellular Ca2+ signals and NFAT activation.
url https://doi.org/10.1038/s41467-019-09593-0
work_keys_str_mv AT xuexinzhang acalciumcampsignalingloopattheorai1mouthdriveschannelinactivationtoshapenfatinduction
AT trayambakpathak acalciumcampsignalingloopattheorai1mouthdriveschannelinactivationtoshapenfatinduction
AT ryanyoast acalciumcampsignalingloopattheorai1mouthdriveschannelinactivationtoshapenfatinduction
AT scottemrich acalciumcampsignalingloopattheorai1mouthdriveschannelinactivationtoshapenfatinduction
AT pingxin acalciumcampsignalingloopattheorai1mouthdriveschannelinactivationtoshapenfatinduction
AT robertmnwokonko acalciumcampsignalingloopattheorai1mouthdriveschannelinactivationtoshapenfatinduction
AT martinjohnson acalciumcampsignalingloopattheorai1mouthdriveschannelinactivationtoshapenfatinduction
AT shilanwu acalciumcampsignalingloopattheorai1mouthdriveschannelinactivationtoshapenfatinduction
AT celinedelierneux acalciumcampsignalingloopattheorai1mouthdriveschannelinactivationtoshapenfatinduction
AT maximegueguinou acalciumcampsignalingloopattheorai1mouthdriveschannelinactivationtoshapenfatinduction
AT nadinehempel acalciumcampsignalingloopattheorai1mouthdriveschannelinactivationtoshapenfatinduction
AT jameswputney acalciumcampsignalingloopattheorai1mouthdriveschannelinactivationtoshapenfatinduction
AT donaldlgill acalciumcampsignalingloopattheorai1mouthdriveschannelinactivationtoshapenfatinduction
AT mohamedtrebak acalciumcampsignalingloopattheorai1mouthdriveschannelinactivationtoshapenfatinduction
AT xuexinzhang calciumcampsignalingloopattheorai1mouthdriveschannelinactivationtoshapenfatinduction
AT trayambakpathak calciumcampsignalingloopattheorai1mouthdriveschannelinactivationtoshapenfatinduction
AT ryanyoast calciumcampsignalingloopattheorai1mouthdriveschannelinactivationtoshapenfatinduction
AT scottemrich calciumcampsignalingloopattheorai1mouthdriveschannelinactivationtoshapenfatinduction
AT pingxin calciumcampsignalingloopattheorai1mouthdriveschannelinactivationtoshapenfatinduction
AT robertmnwokonko calciumcampsignalingloopattheorai1mouthdriveschannelinactivationtoshapenfatinduction
AT martinjohnson calciumcampsignalingloopattheorai1mouthdriveschannelinactivationtoshapenfatinduction
AT shilanwu calciumcampsignalingloopattheorai1mouthdriveschannelinactivationtoshapenfatinduction
AT celinedelierneux calciumcampsignalingloopattheorai1mouthdriveschannelinactivationtoshapenfatinduction
AT maximegueguinou calciumcampsignalingloopattheorai1mouthdriveschannelinactivationtoshapenfatinduction
AT nadinehempel calciumcampsignalingloopattheorai1mouthdriveschannelinactivationtoshapenfatinduction
AT jameswputney calciumcampsignalingloopattheorai1mouthdriveschannelinactivationtoshapenfatinduction
AT donaldlgill calciumcampsignalingloopattheorai1mouthdriveschannelinactivationtoshapenfatinduction
AT mohamedtrebak calciumcampsignalingloopattheorai1mouthdriveschannelinactivationtoshapenfatinduction
_version_ 1721446273808072704

Similar Items