An overview of SARS-COV-2: Virology, Epidemiology, Pathogenesis and Treatment
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a causative agent of COVID-19 infections. In late December, 2019 emergence and pandemic outbreak of SARS-CoV-2 virus has created serious health threat globally, unlike emergence of SARS-CoV in 2002, and Middle East Respiratory Syndrom...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Ain Shams University
2020-06-01
|
Series: | Novel Research in Microbiology Journal |
Subjects: | |
Online Access: | https://nrmj.journals.ekb.eg/article_95319_1f1d6cdb4b9644aa0e8f1cfbb8e373cc.pdf |
id |
doaj-2737bc077f7e4de69aaba62b1c3f0edb |
---|---|
record_format |
Article |
spelling |
doaj-2737bc077f7e4de69aaba62b1c3f0edb2021-04-24T11:08:59ZengAin Shams UniversityNovel Research in Microbiology Journal2537-02862537-02942020-06-014374676510.21608/nrmj.2020.95319An overview of SARS-COV-2: Virology, Epidemiology, Pathogenesis and Treatment Ramesh Bhandari0 Fenyong Sun1Qiuhui Pan2Department of Clinical Laboratory Medicine, Shanghai Tenth People`s Hospital of Tongji University, Shanghai, 200072, ChinaDepartment of Clinical Laboratory Medicine, Shanghai Tenth People`s Hospital of Tongji University, Shanghai, 200072, ChinaDepartment of Clinical Laboratory Medicine, Shanghai Tenth People`s Hospital of Tongji University, Shanghai, 200072, ChinaSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a causative agent of COVID-19 infections. In late December, 2019 emergence and pandemic outbreak of SARS-CoV-2 virus has created serious health threat globally, unlike emergence of SARS-CoV in 2002, and Middle East Respiratory Syndrome (MERSCoV) in 2012. Globally, about 4,434,653 confirmed cases of COVID-19 infections are reported including 302,169 deaths. Wild animals’ bat, snakes, and pangolins are potential sources of this virus, based on the sequence homology of these animals and the nucleic acid of SARS-CoV-2 virus isolated from infected persons. Human infection occurs due to the inhalation of respiratory droplets, which mainly infects the lower respiratory tract causing a mild flu like symptoms that may extend to severe pneumonia. Currently, there are no any vaccines or antiviral drugs against this virus. Treatment of patients is based mainly on symptomatic management. The aims of the present study were to summarize the information on the origin, evolution, structure and genomes, epidemiology, molecular immunopathogenesis, and diagnostic approaches of the SARS-CoV-2 coronavirus. Moreover, we discuss the current approaches, progress in vaccine development, and the antiviral therapies to cope with COVID-19 infection. Thus, the information and data gathered on coronavirus will be helpful in understanding all the aspects on SARS-CoV-2 virus, and helps to reduce the global health threat and economic impact.https://nrmj.journals.ekb.eg/article_95319_1f1d6cdb4b9644aa0e8f1cfbb8e373cc.pdfcoronavirussars-cov-2mers-covsars-covepidemiology |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ramesh Bhandari Fenyong Sun Qiuhui Pan |
spellingShingle |
Ramesh Bhandari Fenyong Sun Qiuhui Pan An overview of SARS-COV-2: Virology, Epidemiology, Pathogenesis and Treatment Novel Research in Microbiology Journal coronavirus sars-cov-2 mers-cov sars-cov epidemiology |
author_facet |
Ramesh Bhandari Fenyong Sun Qiuhui Pan |
author_sort |
Ramesh Bhandari |
title |
An overview of SARS-COV-2: Virology, Epidemiology, Pathogenesis and Treatment |
title_short |
An overview of SARS-COV-2: Virology, Epidemiology, Pathogenesis and Treatment |
title_full |
An overview of SARS-COV-2: Virology, Epidemiology, Pathogenesis and Treatment |
title_fullStr |
An overview of SARS-COV-2: Virology, Epidemiology, Pathogenesis and Treatment |
title_full_unstemmed |
An overview of SARS-COV-2: Virology, Epidemiology, Pathogenesis and Treatment |
title_sort |
overview of sars-cov-2: virology, epidemiology, pathogenesis and treatment |
publisher |
Ain Shams University |
series |
Novel Research in Microbiology Journal |
issn |
2537-0286 2537-0294 |
publishDate |
2020-06-01 |
description |
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a causative agent of COVID-19
infections. In late December, 2019 emergence and pandemic outbreak of SARS-CoV-2 virus has created serious
health threat globally, unlike emergence of SARS-CoV in 2002, and Middle East Respiratory Syndrome (MERSCoV) in 2012. Globally, about 4,434,653 confirmed cases of COVID-19 infections are reported including 302,169
deaths. Wild animals’ bat, snakes, and pangolins are potential sources of this virus, based on the sequence
homology of these animals and the nucleic acid of SARS-CoV-2 virus isolated from infected persons. Human
infection occurs due to the inhalation of respiratory droplets, which mainly infects the lower respiratory tract
causing a mild flu like symptoms that may extend to severe pneumonia. Currently, there are no any vaccines or
antiviral drugs against this virus. Treatment of patients is based mainly on symptomatic management. The aims of
the present study were to summarize the information on the origin, evolution, structure and genomes,
epidemiology, molecular immunopathogenesis, and diagnostic approaches of the SARS-CoV-2 coronavirus.
Moreover, we discuss the current approaches, progress in vaccine development, and the antiviral therapies to cope
with COVID-19 infection. Thus, the information and data gathered on coronavirus will be helpful in
understanding all the aspects on SARS-CoV-2 virus, and helps to reduce the global health threat and economic
impact. |
topic |
coronavirus sars-cov-2 mers-cov sars-cov epidemiology |
url |
https://nrmj.journals.ekb.eg/article_95319_1f1d6cdb4b9644aa0e8f1cfbb8e373cc.pdf |
work_keys_str_mv |
AT rameshbhandari anoverviewofsarscov2virologyepidemiologypathogenesisandtreatment AT fenyongsun anoverviewofsarscov2virologyepidemiologypathogenesisandtreatment AT qiuhuipan anoverviewofsarscov2virologyepidemiologypathogenesisandtreatment AT rameshbhandari overviewofsarscov2virologyepidemiologypathogenesisandtreatment AT fenyongsun overviewofsarscov2virologyepidemiologypathogenesisandtreatment AT qiuhuipan overviewofsarscov2virologyepidemiologypathogenesisandtreatment |
_version_ |
1721511071947161600 |