The Influence of Infection by Different Leishmania (Viannia) braziliensis Isolates on the Pathogenesis of Disseminated Leishmaniasis
Disseminated Leishmaniasis (DL) is an emerging and severe form of Leishmania (Viannia) braziliensis infection defined by the presence of 10 and up to more than 1,000 skin lesions. The mechanisms underlying parasite dissemination remain unknown. Genotypic differences among species of L. braziliensis...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2021-09-01
|
Series: | Frontiers in Cellular and Infection Microbiology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2021.740278/full |
id |
doaj-273ece04941c49208708abd53a47ede8 |
---|---|
record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Walker N. Oliveira Walker N. Oliveira Andreza S. Dórea Andreza S. Dórea Pedro P. Carneiro Pedro P. Carneiro Maurício T. Nascimento Lucas P. Carvalho Lucas P. Carvalho Lucas P. Carvalho Paulo R. L. Machado Paulo R. L. Machado Albert Schriefer Albert Schriefer Albert Schriefer Olívia Bacellar Olívia Bacellar Edgar M. Carvalho Edgar M. Carvalho Edgar M. Carvalho |
spellingShingle |
Walker N. Oliveira Walker N. Oliveira Andreza S. Dórea Andreza S. Dórea Pedro P. Carneiro Pedro P. Carneiro Maurício T. Nascimento Lucas P. Carvalho Lucas P. Carvalho Lucas P. Carvalho Paulo R. L. Machado Paulo R. L. Machado Albert Schriefer Albert Schriefer Albert Schriefer Olívia Bacellar Olívia Bacellar Edgar M. Carvalho Edgar M. Carvalho Edgar M. Carvalho The Influence of Infection by Different Leishmania (Viannia) braziliensis Isolates on the Pathogenesis of Disseminated Leishmaniasis Frontiers in Cellular and Infection Microbiology cutaneous leishmaniasis monocytes inflammatory response disseminated leishmaniasis Leishmania (Viannia) braziliensis |
author_facet |
Walker N. Oliveira Walker N. Oliveira Andreza S. Dórea Andreza S. Dórea Pedro P. Carneiro Pedro P. Carneiro Maurício T. Nascimento Lucas P. Carvalho Lucas P. Carvalho Lucas P. Carvalho Paulo R. L. Machado Paulo R. L. Machado Albert Schriefer Albert Schriefer Albert Schriefer Olívia Bacellar Olívia Bacellar Edgar M. Carvalho Edgar M. Carvalho Edgar M. Carvalho |
author_sort |
Walker N. Oliveira |
title |
The Influence of Infection by Different Leishmania (Viannia) braziliensis Isolates on the Pathogenesis of Disseminated Leishmaniasis |
title_short |
The Influence of Infection by Different Leishmania (Viannia) braziliensis Isolates on the Pathogenesis of Disseminated Leishmaniasis |
title_full |
The Influence of Infection by Different Leishmania (Viannia) braziliensis Isolates on the Pathogenesis of Disseminated Leishmaniasis |
title_fullStr |
The Influence of Infection by Different Leishmania (Viannia) braziliensis Isolates on the Pathogenesis of Disseminated Leishmaniasis |
title_full_unstemmed |
The Influence of Infection by Different Leishmania (Viannia) braziliensis Isolates on the Pathogenesis of Disseminated Leishmaniasis |
title_sort |
influence of infection by different leishmania (viannia) braziliensis isolates on the pathogenesis of disseminated leishmaniasis |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular and Infection Microbiology |
issn |
2235-2988 |
publishDate |
2021-09-01 |
description |
Disseminated Leishmaniasis (DL) is an emerging and severe form of Leishmania (Viannia) braziliensis infection defined by the presence of 10 and up to more than 1,000 skin lesions. The mechanisms underlying parasite dissemination remain unknown. Genotypic differences among species of L. braziliensis have been associated with different clinical forms of disease. The present work compared the function of monocytes obtained from patients with cutaneous leishmaniasis (CL) and DL in response to infection with L. braziliensis isolates of both these two clinical forms of disease. Mononuclear cells obtained from DL and CL patients were infected with different L. braziliensis isolates, and numbers of infected cells, parasite load, respiratory burst, TLR2 and TLR4 expression and cytokine production were evaluated. DL isolates infected more monocytes, induced greater respiratory burst, and more cytokine production compared to isolates from CL patients regardless of the origin of monocytes (DL or CL). However, greater parasite multiplication and higher TLR2 and TLR4 expression were seen in monocytes from DL patients compared to CL following infection with DL isolates. Our results indicate the participation of both parasite genotype and host factors in the pathogenesis of DL. |
topic |
cutaneous leishmaniasis monocytes inflammatory response disseminated leishmaniasis Leishmania (Viannia) braziliensis |
url |
https://www.frontiersin.org/articles/10.3389/fcimb.2021.740278/full |
work_keys_str_mv |
AT walkernoliveira theinfluenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT walkernoliveira theinfluenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT andrezasdorea theinfluenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT andrezasdorea theinfluenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT pedropcarneiro theinfluenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT pedropcarneiro theinfluenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT mauriciotnascimento theinfluenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT lucaspcarvalho theinfluenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT lucaspcarvalho theinfluenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT lucaspcarvalho theinfluenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT paulorlmachado theinfluenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT paulorlmachado theinfluenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT albertschriefer theinfluenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT albertschriefer theinfluenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT albertschriefer theinfluenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT oliviabacellar theinfluenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT oliviabacellar theinfluenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT edgarmcarvalho theinfluenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT edgarmcarvalho theinfluenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT edgarmcarvalho theinfluenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT walkernoliveira influenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT walkernoliveira influenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT andrezasdorea influenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT andrezasdorea influenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT pedropcarneiro influenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT pedropcarneiro influenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT mauriciotnascimento influenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT lucaspcarvalho influenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT lucaspcarvalho influenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT lucaspcarvalho influenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT paulorlmachado influenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT paulorlmachado influenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT albertschriefer influenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT albertschriefer influenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT albertschriefer influenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT oliviabacellar influenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT oliviabacellar influenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT edgarmcarvalho influenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT edgarmcarvalho influenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis AT edgarmcarvalho influenceofinfectionbydifferentleishmaniavianniabraziliensisisolatesonthepathogenesisofdisseminatedleishmaniasis |
_version_ |
1717758585297960960 |
spelling |
doaj-273ece04941c49208708abd53a47ede82021-09-10T05:32:24ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882021-09-011110.3389/fcimb.2021.740278740278The Influence of Infection by Different Leishmania (Viannia) braziliensis Isolates on the Pathogenesis of Disseminated LeishmaniasisWalker N. Oliveira0Walker N. Oliveira1Andreza S. Dórea2Andreza S. Dórea3Pedro P. Carneiro4Pedro P. Carneiro5Maurício T. Nascimento6Lucas P. Carvalho7Lucas P. Carvalho8Lucas P. Carvalho9Paulo R. L. Machado10Paulo R. L. Machado11Albert Schriefer12Albert Schriefer13Albert Schriefer14Olívia Bacellar15Olívia Bacellar16Edgar M. Carvalho17Edgar M. Carvalho18Edgar M. Carvalho19Serviço de Imunologia, Complexo Hospitalar Universitário Prof. Edgard Santos, Universidade Federal da Bahia, Salvador, BrazilInstituto Nacional de Ciência e Tecnologia de Doenças Tropicais - INCT-DT (CNPq/MCT), Salvador, BrazilServiço de Imunologia, Complexo Hospitalar Universitário Prof. Edgard Santos, Universidade Federal da Bahia, Salvador, BrazilInstituto Nacional de Ciência e Tecnologia de Doenças Tropicais - INCT-DT (CNPq/MCT), Salvador, BrazilServiço de Imunologia, Complexo Hospitalar Universitário Prof. Edgard Santos, Universidade Federal da Bahia, Salvador, BrazilInstituto Nacional de Ciência e Tecnologia de Doenças Tropicais - INCT-DT (CNPq/MCT), Salvador, BrazilInstituto Pesquisa Gonçalo Moniz – Fiocruz-Bahia, Salvador, BrazilInstituto Nacional de Ciência e Tecnologia de Doenças Tropicais - INCT-DT (CNPq/MCT), Salvador, BrazilInstituto Pesquisa Gonçalo Moniz – Fiocruz-Bahia, Salvador, BrazilDepartamento de Ciências da Biointeração, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, BrazilServiço de Imunologia, Complexo Hospitalar Universitário Prof. Edgard Santos, Universidade Federal da Bahia, Salvador, BrazilInstituto Nacional de Ciência e Tecnologia de Doenças Tropicais - INCT-DT (CNPq/MCT), Salvador, BrazilServiço de Imunologia, Complexo Hospitalar Universitário Prof. Edgard Santos, Universidade Federal da Bahia, Salvador, BrazilInstituto Nacional de Ciência e Tecnologia de Doenças Tropicais - INCT-DT (CNPq/MCT), Salvador, BrazilDepartamento de Ciências da Biointeração, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, BrazilServiço de Imunologia, Complexo Hospitalar Universitário Prof. Edgard Santos, Universidade Federal da Bahia, Salvador, BrazilInstituto Nacional de Ciência e Tecnologia de Doenças Tropicais - INCT-DT (CNPq/MCT), Salvador, BrazilServiço de Imunologia, Complexo Hospitalar Universitário Prof. Edgard Santos, Universidade Federal da Bahia, Salvador, BrazilInstituto Nacional de Ciência e Tecnologia de Doenças Tropicais - INCT-DT (CNPq/MCT), Salvador, BrazilInstituto Pesquisa Gonçalo Moniz – Fiocruz-Bahia, Salvador, BrazilDisseminated Leishmaniasis (DL) is an emerging and severe form of Leishmania (Viannia) braziliensis infection defined by the presence of 10 and up to more than 1,000 skin lesions. The mechanisms underlying parasite dissemination remain unknown. Genotypic differences among species of L. braziliensis have been associated with different clinical forms of disease. The present work compared the function of monocytes obtained from patients with cutaneous leishmaniasis (CL) and DL in response to infection with L. braziliensis isolates of both these two clinical forms of disease. Mononuclear cells obtained from DL and CL patients were infected with different L. braziliensis isolates, and numbers of infected cells, parasite load, respiratory burst, TLR2 and TLR4 expression and cytokine production were evaluated. DL isolates infected more monocytes, induced greater respiratory burst, and more cytokine production compared to isolates from CL patients regardless of the origin of monocytes (DL or CL). However, greater parasite multiplication and higher TLR2 and TLR4 expression were seen in monocytes from DL patients compared to CL following infection with DL isolates. Our results indicate the participation of both parasite genotype and host factors in the pathogenesis of DL.https://www.frontiersin.org/articles/10.3389/fcimb.2021.740278/fullcutaneous leishmaniasismonocytesinflammatory responsedisseminated leishmaniasisLeishmania (Viannia) braziliensis |