Molecular Signature of Cancer at Gene Level or Pathway Level? Case Studies of Colorectal Cancer and Prostate Cancer Microarray Data
With recent advances in microarray technology, there has been a flourish in genome-scale identification of molecular signatures for cancer. However, the differentially expressed genes obtained by different laboratories are highly divergent. The present discrepancy at gene level indicates a need for...
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Series: | Computational and Mathematical Methods in Medicine |
Online Access: | http://dx.doi.org/10.1155/2013/909525 |
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doaj-2740bad53098438fbba37d4b1f6a96292020-11-25T00:56:34ZengHindawi LimitedComputational and Mathematical Methods in Medicine1748-670X1748-67182013-01-01201310.1155/2013/909525909525Molecular Signature of Cancer at Gene Level or Pathway Level? Case Studies of Colorectal Cancer and Prostate Cancer Microarray DataJiajia Chen0Ying Wang1Bairong Shen2Daqing Zhang3Center for Systems Biology, Soochow University, Jiangsu, Suzhou 215006, ChinaCenter for Systems Biology, Soochow University, Jiangsu, Suzhou 215006, ChinaCenter for Systems Biology, Soochow University, Jiangsu, Suzhou 215006, ChinaCenter for Systems Biology, Soochow University, Jiangsu, Suzhou 215006, ChinaWith recent advances in microarray technology, there has been a flourish in genome-scale identification of molecular signatures for cancer. However, the differentially expressed genes obtained by different laboratories are highly divergent. The present discrepancy at gene level indicates a need for a novel strategy to obtain more robust signatures for cancer. In this paper we hypothesize that (1) the expression signatures of different cancer microarray datasets are more similar at pathway level than at gene level; (2) the comparability of the cancer molecular mechanisms of different individuals is related to their genetic similarities. In support of the hypotheses, we summarized theoretical and experimental evidences, and conducted case studies on colorectal and prostate cancer microarray datasets. Based on the above assumption, we propose that reliable cancer signatures should be investigated in the context of biological pathways, within a cohort of genetically homogeneous population. It is hoped that the hypotheses can guide future research in cancer mechanism and signature discovery.http://dx.doi.org/10.1155/2013/909525 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jiajia Chen Ying Wang Bairong Shen Daqing Zhang |
spellingShingle |
Jiajia Chen Ying Wang Bairong Shen Daqing Zhang Molecular Signature of Cancer at Gene Level or Pathway Level? Case Studies of Colorectal Cancer and Prostate Cancer Microarray Data Computational and Mathematical Methods in Medicine |
author_facet |
Jiajia Chen Ying Wang Bairong Shen Daqing Zhang |
author_sort |
Jiajia Chen |
title |
Molecular Signature of Cancer at Gene Level or Pathway Level? Case Studies of Colorectal Cancer and Prostate Cancer Microarray Data |
title_short |
Molecular Signature of Cancer at Gene Level or Pathway Level? Case Studies of Colorectal Cancer and Prostate Cancer Microarray Data |
title_full |
Molecular Signature of Cancer at Gene Level or Pathway Level? Case Studies of Colorectal Cancer and Prostate Cancer Microarray Data |
title_fullStr |
Molecular Signature of Cancer at Gene Level or Pathway Level? Case Studies of Colorectal Cancer and Prostate Cancer Microarray Data |
title_full_unstemmed |
Molecular Signature of Cancer at Gene Level or Pathway Level? Case Studies of Colorectal Cancer and Prostate Cancer Microarray Data |
title_sort |
molecular signature of cancer at gene level or pathway level? case studies of colorectal cancer and prostate cancer microarray data |
publisher |
Hindawi Limited |
series |
Computational and Mathematical Methods in Medicine |
issn |
1748-670X 1748-6718 |
publishDate |
2013-01-01 |
description |
With recent advances in microarray technology, there has been a flourish in genome-scale identification of molecular signatures for cancer. However, the differentially expressed genes obtained by different laboratories are highly divergent. The present discrepancy at gene level indicates a need for a novel strategy to obtain more robust signatures for cancer. In this paper we hypothesize that (1) the expression signatures of different cancer microarray datasets are more similar at pathway level than at gene level; (2) the comparability of the cancer molecular mechanisms of different individuals is related to their genetic similarities. In support of the hypotheses, we summarized theoretical and experimental evidences, and conducted case studies on colorectal and prostate cancer microarray datasets. Based on the above assumption, we propose that reliable cancer signatures should be investigated in the context of biological pathways, within a cohort of genetically homogeneous population. It is hoped that the hypotheses can guide future research in cancer mechanism and signature discovery. |
url |
http://dx.doi.org/10.1155/2013/909525 |
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