Cytokine-Leukotriene Receptor Interactions

Cytokine-Leukotriene Receptor Interactions

Biochemical and pharmacological studies have identified the structure of leukotrienes, the pathways that lead to their synthesis, and the signaling events they trigger when they interact with their cognate receptors. A privileged interaction exists between these lipid mediators and another group of...

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Main Authors: Marek Rola-Pleszczynski, Jana Stankova
Format: Article
Language:English
Published: Hindawi Limited 2007-01-01
Series:The Scientific World Journal
Online Access:http://dx.doi.org/10.1100/tsw.2007.183
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spelling doaj-274695b522a54a71afa8de929b236c7a2020-11-25T02:15:34ZengHindawi LimitedThe Scientific World Journal1537-744X2007-01-0171348135810.1100/tsw.2007.183Cytokine-Leukotriene Receptor InteractionsMarek Rola-Pleszczynski0Jana Stankova1Immunology Division, Department of Pediatrics, Faculty of Medicine, Université de Sherbrooke, Sherbrooke QC, J1H 5N4, CanadaImmunology Division, Department of Pediatrics, Faculty of Medicine, Université de Sherbrooke, Sherbrooke QC, J1H 5N4, CanadaBiochemical and pharmacological studies have identified the structure of leukotrienes, the pathways that lead to their synthesis, and the signaling events they trigger when they interact with their cognate receptors. A privileged interaction exists between these lipid mediators and another group of molecules essential for inflammation and immune modulation, namely, cytokines. Whereas leukotrienes can trigger the synthesis and release of selected cytokines in distinct cell populations, many cytokines can affect cellular responsiveness to leukotrienes by modulating leukotriene receptor expression. As we progressively begin to unravel these complex interactions, new areas of cell-cell communication and eventual therapeutic interventions will emerge.http://dx.doi.org/10.1100/tsw.2007.183
collection DOAJ
language English
format Article
sources DOAJ
author Marek Rola-Pleszczynski
Jana Stankova
spellingShingle Marek Rola-Pleszczynski
Jana Stankova
Cytokine-Leukotriene Receptor Interactions
The Scientific World Journal
author_facet Marek Rola-Pleszczynski
Jana Stankova
author_sort Marek Rola-Pleszczynski
title Cytokine-Leukotriene Receptor Interactions
title_short Cytokine-Leukotriene Receptor Interactions
title_full Cytokine-Leukotriene Receptor Interactions
title_fullStr Cytokine-Leukotriene Receptor Interactions
title_full_unstemmed Cytokine-Leukotriene Receptor Interactions
title_sort cytokine-leukotriene receptor interactions
publisher Hindawi Limited
series The Scientific World Journal
issn 1537-744X
publishDate 2007-01-01
description Biochemical and pharmacological studies have identified the structure of leukotrienes, the pathways that lead to their synthesis, and the signaling events they trigger when they interact with their cognate receptors. A privileged interaction exists between these lipid mediators and another group of molecules essential for inflammation and immune modulation, namely, cytokines. Whereas leukotrienes can trigger the synthesis and release of selected cytokines in distinct cell populations, many cytokines can affect cellular responsiveness to leukotrienes by modulating leukotriene receptor expression. As we progressively begin to unravel these complex interactions, new areas of cell-cell communication and eventual therapeutic interventions will emerge.
url http://dx.doi.org/10.1100/tsw.2007.183
work_keys_str_mv AT marekrolapleszczynski cytokineleukotrienereceptorinteractions
AT janastankova cytokineleukotrienereceptorinteractions
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