Generating DNA profile from low copy number DNA: Strategies and associated risks

Many shreds of evidence found on the crime scenes contain a trace amount of DNA which results in insignificant profiling results for subsequent comparison. This can nullify the potential evidence material and hamper investigation process. Over the years, different strategies have been employed by va...

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Bibliographic Details
Main Authors: Rana Muhammad Mateen, Asma Tariq, Mureed Hussain
Format: Article
Language:English
Published: Universidade Estadual de Maringá 2020-07-01
Series:Acta Scientiarum : Biological Sciences
Subjects:
Online Access:http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/52239
Description
Summary:Many shreds of evidence found on the crime scenes contain a trace amount of DNA which results in insignificant profiling results for subsequent comparison. This can nullify the potential evidence material and hamper investigation process. Over the years, different strategies have been employed by various DNA testing laboratories to create interpretable DNA profiles generated from low template of DNA. This review highlights different strategies used by forensic laboratories worldwide for creating complete DNA profiles from low copy number template for comparison purposes along with its associated risks for forensic purposes
ISSN:1679-9283
1807-863X