Therapeutic Effects of Cortex acanthopanacis Aqueous Extract on Bone Metabolism of Ovariectomized Rats
The aim of this study was to evaluate effects of aqueous extract from Cortex acanthopanacis (CAE) on osteoporosis rats induced by ovariectomy (OVX) using aqueous extract from Folium Epimedii (FEE) as positive control agent. Three-month-old female rats that underwent OVX were treated with CAE. After...
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2012-01-01
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Series: | Evidence-Based Complementary and Alternative Medicine |
Online Access: | http://dx.doi.org/10.1155/2012/492627 |
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doaj-275552566f044695bb1b6de0d5ff111d2020-11-24T23:56:01ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882012-01-01201210.1155/2012/492627492627Therapeutic Effects of Cortex acanthopanacis Aqueous Extract on Bone Metabolism of Ovariectomized RatsZhiguo Zhang0Jiazi Dong1Meijie Liu2Yan Li3Jinghua Pan4Hong Liu5Wenlai Wang6Dong Bai7Lihua Xiang8Gary G. Xiao9Dahong Ju10Institute of Basic Theory, China Academy of Chinese Medical Sciences, No. 16 Nanxiao Road, Dongzhimennei, Beijing 100700, ChinaInstitute of Basic Theory, China Academy of Chinese Medical Sciences, No. 16 Nanxiao Road, Dongzhimennei, Beijing 100700, ChinaInstitute of Basic Theory, China Academy of Chinese Medical Sciences, No. 16 Nanxiao Road, Dongzhimennei, Beijing 100700, ChinaInstitute of Basic Theory, China Academy of Chinese Medical Sciences, No. 16 Nanxiao Road, Dongzhimennei, Beijing 100700, ChinaInstitute of Basic Theory, China Academy of Chinese Medical Sciences, No. 16 Nanxiao Road, Dongzhimennei, Beijing 100700, ChinaInstitute of Basic Theory, China Academy of Chinese Medical Sciences, No. 16 Nanxiao Road, Dongzhimennei, Beijing 100700, ChinaInstitute of Basic Theory, China Academy of Chinese Medical Sciences, No. 16 Nanxiao Road, Dongzhimennei, Beijing 100700, ChinaInstitute of Basic Theory, China Academy of Chinese Medical Sciences, No. 16 Nanxiao Road, Dongzhimennei, Beijing 100700, ChinaInstitute of Basic Theory, China Academy of Chinese Medical Sciences, No. 16 Nanxiao Road, Dongzhimennei, Beijing 100700, ChinaFunctional Genomics & Proteomics Laboratory, Osteoporosis Research Center, Creighton University Medical Center, 601N 30th ST, Suite 6730, Omaha, NE 68131, USAInstitute of Basic Theory, China Academy of Chinese Medical Sciences, No. 16 Nanxiao Road, Dongzhimennei, Beijing 100700, ChinaThe aim of this study was to evaluate effects of aqueous extract from Cortex acanthopanacis (CAE) on osteoporosis rats induced by ovariectomy (OVX) using aqueous extract from Folium Epimedii (FEE) as positive control agent. Three-month-old female rats that underwent OVX were treated with CAE. After 12 weeks, bone mineral density (BMD) and indices of bone histomorphometry of tibia were measured. Levels of protein and mRNA expression of osteoprotegerin (OPG) and receptor activator of nuclear factor kappa-B ligand (RANKL) in tibia were evaluated. In addition, the serum concentrations of osteocalcin (OC), interleukin-1 beta (IL-1β), interleukin-6 (IL-6), calcitonin (CT), and parathyroid hormone (PTH) were determined. Administration of CAE significantly prevented OVX-induced rats from gain of the body weight. Treatment with CAE increased bone mass remarkably and showed a significant inhibitory effect on bone resorption by downregulating significantly the expression of RANKL in tibia of OVX rats. Meanwhile, treatment of CAE significantly reduced serum level of IL-1β and increased level of CT in OVX rats. This suggests that CAE has the potential to be used as an alternative therapeutic agent for postmenopausal osteoporosis.http://dx.doi.org/10.1155/2012/492627 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhiguo Zhang Jiazi Dong Meijie Liu Yan Li Jinghua Pan Hong Liu Wenlai Wang Dong Bai Lihua Xiang Gary G. Xiao Dahong Ju |
spellingShingle |
Zhiguo Zhang Jiazi Dong Meijie Liu Yan Li Jinghua Pan Hong Liu Wenlai Wang Dong Bai Lihua Xiang Gary G. Xiao Dahong Ju Therapeutic Effects of Cortex acanthopanacis Aqueous Extract on Bone Metabolism of Ovariectomized Rats Evidence-Based Complementary and Alternative Medicine |
author_facet |
Zhiguo Zhang Jiazi Dong Meijie Liu Yan Li Jinghua Pan Hong Liu Wenlai Wang Dong Bai Lihua Xiang Gary G. Xiao Dahong Ju |
author_sort |
Zhiguo Zhang |
title |
Therapeutic Effects of Cortex acanthopanacis Aqueous Extract on Bone Metabolism of Ovariectomized Rats |
title_short |
Therapeutic Effects of Cortex acanthopanacis Aqueous Extract on Bone Metabolism of Ovariectomized Rats |
title_full |
Therapeutic Effects of Cortex acanthopanacis Aqueous Extract on Bone Metabolism of Ovariectomized Rats |
title_fullStr |
Therapeutic Effects of Cortex acanthopanacis Aqueous Extract on Bone Metabolism of Ovariectomized Rats |
title_full_unstemmed |
Therapeutic Effects of Cortex acanthopanacis Aqueous Extract on Bone Metabolism of Ovariectomized Rats |
title_sort |
therapeutic effects of cortex acanthopanacis aqueous extract on bone metabolism of ovariectomized rats |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2012-01-01 |
description |
The aim of this study was to evaluate effects of aqueous extract from Cortex acanthopanacis (CAE) on osteoporosis rats induced by ovariectomy (OVX) using aqueous extract from Folium Epimedii (FEE) as positive control agent. Three-month-old female rats that underwent OVX were treated with CAE. After 12 weeks, bone mineral density (BMD) and indices of bone histomorphometry of tibia were measured. Levels of protein and mRNA expression of osteoprotegerin (OPG) and receptor activator of nuclear factor kappa-B ligand (RANKL) in tibia were evaluated. In addition, the serum concentrations of osteocalcin (OC), interleukin-1 beta (IL-1β), interleukin-6 (IL-6), calcitonin (CT), and parathyroid hormone (PTH) were determined. Administration of CAE significantly prevented OVX-induced rats from gain of the body weight. Treatment with CAE increased bone mass remarkably and showed a significant inhibitory effect on bone resorption by downregulating significantly the expression of RANKL in tibia of OVX rats. Meanwhile, treatment of CAE significantly reduced serum level of IL-1β and increased level of CT in OVX rats. This suggests that CAE has the potential to be used as an alternative therapeutic agent for postmenopausal osteoporosis. |
url |
http://dx.doi.org/10.1155/2012/492627 |
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