Periodontal Disease and Incident CKD in US Hispanics/Latinos: The Hispanic Community Health Study/Study of LatinosPlain-Language Summary
Rationale & Objective: Recent studies suggest that periodontal disease may be associated with incident chronic kidney disease (CKD). However, studies have focused on older populations, and US Hispanics/Latinos were not well represented. Study Design: Observational cohort. Setting & P...
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doaj-2755b9143edd41748b36b755de8e49ab2021-08-04T04:20:39ZengElsevierKidney Medicine2590-05952021-07-0134528535.e1Periodontal Disease and Incident CKD in US Hispanics/Latinos: The Hispanic Community Health Study/Study of LatinosPlain-Language SummaryStephanie M. Toth-Manikowski, MD0Ana C. Ricardo, MD1Christian R. Salazar, PhD2Jinsong Chen, PhD3Tasneem Khambaty, PhD4Jannel Liu, BS5Richard H. Singer, DMD, MS, PhD6Marston E. Youngblood, MPH7Jianwen Cai, PhD8Linda M. Kaste, DDS, PhD9Martha L. Daviglus, MD10James P. Lash, MD11Department of Medicine, University of Illinois at Chicago, Chicago, ILDepartment of Medicine, University of Illinois at Chicago, Chicago, ILDepartment of Epidemiology and Health Promotion, New York University College of Dentistry, New York, NYDepartment of Medicine, University of Illinois at Chicago, Chicago, ILDepartment of Psychology, University of Maryland, Baltimore, MDDepartment of Medicine, University of Illinois at Chicago, Chicago, ILDepartment of Orthodontics and Dentofacial Orthopedics, Nova Southeastern University College of Dental Medicine, Ft. Lauderdale, FLDepartment of Biostatistics, University of North Carolina, Chapel Hill, NCDepartment of Biostatistics, University of North Carolina, Chapel Hill, NCDepartment of Oral Biology, University of Illinois at Chicago College of Dentistry, Chicago, ILDepartment of Medicine, University of Illinois at Chicago, Chicago, IL; Institute of Minority Health Research, University of Illinois at Chicago, Chicago, ILDepartment of Medicine, University of Illinois at Chicago, Chicago, IL; Address for Correspondence: James P. Lash, MD, Division of Nephrology, Department of Medicine, 820 South Wood Street, M/C 793.Rationale & Objective: Recent studies suggest that periodontal disease may be associated with incident chronic kidney disease (CKD). However, studies have focused on older populations, and US Hispanics/Latinos were not well represented. Study Design: Observational cohort. Setting & Participants: We analyzed data from the Hispanic Community Health Study/Study of Latinos who completed a baseline visit with a periodontal examination and a follow-up visit, and did not have CKD at baseline. Predictors: Predictors included ≥30% of sites with clinical attachment loss ≥3 mm, ≥30% of sites with probing depth ≥4 mm, percentage of sites with bleeding on probing, and absence of functional dentition (<21 permanent teeth present). Outcomes: Outcomes were incident low estimated glomerular filtration rate (eGFR) (eGFR <60 mL/min/1.73 m2 and decline in eGFR ≥1 mL/min/year); incident albuminuria (urine albumin:creatinine ratio [ACR] ≥30 mg/g); and change in eGFR and ACR. Analytic Approach: Poisson and linear regression. Results: For the sample (n = 7.732), baseline mean age was 41.5 years, 45.2% were male, 11.7% had ≥30% of sites with clinical attachment loss ≥3 mm, 5.1% had ≥30% of sites with probing depth ≥4 mm, 30.7% had ≥50% of sites with bleeding on probing, and 16.2% had absent functional dentition. During a median follow-up of 5.9 years, 149 patients developed low eGFR and 415 patients developed albuminuria. On multivariable analysis, presence versus absence of ≥30% of sites with probing depth ≥4 mm and absence of functional dentition were each associated with increased risk for incident low eGFR (incident density ratio, 2.31; 95% CI, 1.14-4.65 and 1.65, 95% CI, 1.01-2.70, respectively). None of the other predictors were associated with outcomes. Limitations: Only a single kidney function follow-up measure. Conclusions: In this cohort of US Hispanics/Latinos, we found that select measures of periodontal disease were associated with incident low eGFR. Future work is needed to assess whether the treatment of periodontal disease may prevent CKD.http://www.sciencedirect.com/science/article/pii/S259005952100145Xchronc kidney diseaseperiodontal disease |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Stephanie M. Toth-Manikowski, MD Ana C. Ricardo, MD Christian R. Salazar, PhD Jinsong Chen, PhD Tasneem Khambaty, PhD Jannel Liu, BS Richard H. Singer, DMD, MS, PhD Marston E. Youngblood, MPH Jianwen Cai, PhD Linda M. Kaste, DDS, PhD Martha L. Daviglus, MD James P. Lash, MD |
spellingShingle |
Stephanie M. Toth-Manikowski, MD Ana C. Ricardo, MD Christian R. Salazar, PhD Jinsong Chen, PhD Tasneem Khambaty, PhD Jannel Liu, BS Richard H. Singer, DMD, MS, PhD Marston E. Youngblood, MPH Jianwen Cai, PhD Linda M. Kaste, DDS, PhD Martha L. Daviglus, MD James P. Lash, MD Periodontal Disease and Incident CKD in US Hispanics/Latinos: The Hispanic Community Health Study/Study of LatinosPlain-Language Summary Kidney Medicine chronc kidney disease periodontal disease |
author_facet |
Stephanie M. Toth-Manikowski, MD Ana C. Ricardo, MD Christian R. Salazar, PhD Jinsong Chen, PhD Tasneem Khambaty, PhD Jannel Liu, BS Richard H. Singer, DMD, MS, PhD Marston E. Youngblood, MPH Jianwen Cai, PhD Linda M. Kaste, DDS, PhD Martha L. Daviglus, MD James P. Lash, MD |
author_sort |
Stephanie M. Toth-Manikowski, MD |
title |
Periodontal Disease and Incident CKD in US Hispanics/Latinos: The Hispanic Community Health Study/Study of LatinosPlain-Language Summary |
title_short |
Periodontal Disease and Incident CKD in US Hispanics/Latinos: The Hispanic Community Health Study/Study of LatinosPlain-Language Summary |
title_full |
Periodontal Disease and Incident CKD in US Hispanics/Latinos: The Hispanic Community Health Study/Study of LatinosPlain-Language Summary |
title_fullStr |
Periodontal Disease and Incident CKD in US Hispanics/Latinos: The Hispanic Community Health Study/Study of LatinosPlain-Language Summary |
title_full_unstemmed |
Periodontal Disease and Incident CKD in US Hispanics/Latinos: The Hispanic Community Health Study/Study of LatinosPlain-Language Summary |
title_sort |
periodontal disease and incident ckd in us hispanics/latinos: the hispanic community health study/study of latinosplain-language summary |
publisher |
Elsevier |
series |
Kidney Medicine |
issn |
2590-0595 |
publishDate |
2021-07-01 |
description |
Rationale & Objective: Recent studies suggest that periodontal disease may be associated with incident chronic kidney disease (CKD). However, studies have focused on older populations, and US Hispanics/Latinos were not well represented. Study Design: Observational cohort. Setting & Participants: We analyzed data from the Hispanic Community Health Study/Study of Latinos who completed a baseline visit with a periodontal examination and a follow-up visit, and did not have CKD at baseline. Predictors: Predictors included ≥30% of sites with clinical attachment loss ≥3 mm, ≥30% of sites with probing depth ≥4 mm, percentage of sites with bleeding on probing, and absence of functional dentition (<21 permanent teeth present). Outcomes: Outcomes were incident low estimated glomerular filtration rate (eGFR) (eGFR <60 mL/min/1.73 m2 and decline in eGFR ≥1 mL/min/year); incident albuminuria (urine albumin:creatinine ratio [ACR] ≥30 mg/g); and change in eGFR and ACR. Analytic Approach: Poisson and linear regression. Results: For the sample (n = 7.732), baseline mean age was 41.5 years, 45.2% were male, 11.7% had ≥30% of sites with clinical attachment loss ≥3 mm, 5.1% had ≥30% of sites with probing depth ≥4 mm, 30.7% had ≥50% of sites with bleeding on probing, and 16.2% had absent functional dentition. During a median follow-up of 5.9 years, 149 patients developed low eGFR and 415 patients developed albuminuria. On multivariable analysis, presence versus absence of ≥30% of sites with probing depth ≥4 mm and absence of functional dentition were each associated with increased risk for incident low eGFR (incident density ratio, 2.31; 95% CI, 1.14-4.65 and 1.65, 95% CI, 1.01-2.70, respectively). None of the other predictors were associated with outcomes. Limitations: Only a single kidney function follow-up measure. Conclusions: In this cohort of US Hispanics/Latinos, we found that select measures of periodontal disease were associated with incident low eGFR. Future work is needed to assess whether the treatment of periodontal disease may prevent CKD. |
topic |
chronc kidney disease periodontal disease |
url |
http://www.sciencedirect.com/science/article/pii/S259005952100145X |
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