Fractional Flow Reserve Measurement by Coronary Computed Tomography Angiography: A Review with Future Directions

• Main Authors: Asim Rizvi, Ji Hyun Lee, Bríain ó Hartaigh, Donghee Han, Mahn Won Park, Hadi Mirhedayati Roudsari, Bin Lu, Fay Y. Lin, James K. Min
• Format: Article
• Language: English
• Published: Compuscript 2016-12-01
• Series: Cardiovascular Innovations and Applications
• Subjects: Fractional flow reserve; fractional flow reserve measurement by coronary computed tomography angiography; coronary computed tomography angiography; computational fluid dynamics
• Online Access: http://www.ingentaconnect.com/content/cscript/cvia/2016/00000002/00000001/art00011

Invasive fractional flow reserve (FFR) measurement is currently the gold standard for coronary intervention. FFR measurement by coronary computed tomography angiography (FFRCT) is a novel and promising imaging technology that permits noninvasive assessment of physiologically significant coronary lesions. FFRCT is capable of combining the anatomic information provided by coronary computed tomography angiography with computational fluid dynamics to compute FFR. To date, several studies have reported the diagnostic performance of FFRCT compared with invasive FFR measurement as the reference standard. Further studies are now being implemented to determine the clinical feasibility and economic implications of FFRCT techniques. This article provides an overview and discusses the available evidence as well as potential future directions of FFRCT.