Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis

Here the authors provide a single-cell characterization of cerebrospinal fluid and blood of newly diagnosed multiple sclerosis (MS) patients, revealing altered composition of lymphocyte and monocyte subsets, validated by other methods including the interrogation of the TFH subset in mouse models of...

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Main Authors:	David Schafflick, Chenling A. Xu, Maike Hartlehnert, Michael Cole, Andreas Schulte-Mecklenbeck, Tobias Lautwein, Jolien Wolbert, Michael Heming, Sven G. Meuth, Tanja Kuhlmann, Catharina C. Gross, Heinz Wiendl, Nir Yosef, Gerd Meyer zu Horste
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-14118-w

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spelling	doaj-2757449eb302442da1fbdc95f72a25a42021-05-11T08:05:11ZengNature Publishing GroupNature Communications2041-17232020-01-0111111410.1038/s41467-019-14118-wIntegrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosisDavid Schafflick0Chenling A. Xu1Maike Hartlehnert2Michael Cole3Andreas Schulte-Mecklenbeck4Tobias Lautwein5Jolien Wolbert6Michael Heming7Sven G. Meuth8Tanja Kuhlmann9Catharina C. Gross10Heinz Wiendl11Nir Yosef12Gerd Meyer zu Horste13Department of Neurology with Institute of Translational Neurology, University Hospital MünsterDepartment of Electrical Engineering & Computer Science, Center for Computational Biology, University of CaliforniaDepartment of Neurology with Institute of Translational Neurology, University Hospital MünsterDepartment of Electrical Engineering & Computer Science, Center for Computational Biology, University of CaliforniaDepartment of Neurology with Institute of Translational Neurology, University Hospital MünsterDepartment of Neurology with Institute of Translational Neurology, University Hospital MünsterDepartment of Neurology with Institute of Translational Neurology, University Hospital MünsterDepartment of Neurology with Institute of Translational Neurology, University Hospital MünsterDepartment of Neurology with Institute of Translational Neurology, University Hospital MünsterInstitute of Neuropathology, University Hospital MünsterDepartment of Neurology with Institute of Translational Neurology, University Hospital MünsterDepartment of Neurology with Institute of Translational Neurology, University Hospital MünsterDepartment of Physics, University of CaliforniaDepartment of Neurology with Institute of Translational Neurology, University Hospital MünsterHere the authors provide a single-cell characterization of cerebrospinal fluid and blood of newly diagnosed multiple sclerosis (MS) patients, revealing altered composition of lymphocyte and monocyte subsets, validated by other methods including the interrogation of the TFH subset in mouse models of MS.https://doi.org/10.1038/s41467-019-14118-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	David Schafflick Chenling A. Xu Maike Hartlehnert Michael Cole Andreas Schulte-Mecklenbeck Tobias Lautwein Jolien Wolbert Michael Heming Sven G. Meuth Tanja Kuhlmann Catharina C. Gross Heinz Wiendl Nir Yosef Gerd Meyer zu Horste
spellingShingle	David Schafflick Chenling A. Xu Maike Hartlehnert Michael Cole Andreas Schulte-Mecklenbeck Tobias Lautwein Jolien Wolbert Michael Heming Sven G. Meuth Tanja Kuhlmann Catharina C. Gross Heinz Wiendl Nir Yosef Gerd Meyer zu Horste Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis Nature Communications
author_facet	David Schafflick Chenling A. Xu Maike Hartlehnert Michael Cole Andreas Schulte-Mecklenbeck Tobias Lautwein Jolien Wolbert Michael Heming Sven G. Meuth Tanja Kuhlmann Catharina C. Gross Heinz Wiendl Nir Yosef Gerd Meyer zu Horste
author_sort	David Schafflick
title	Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis
title_short	Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis
title_full	Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis
title_fullStr	Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis
title_full_unstemmed	Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis
title_sort	integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-01-01
description	Here the authors provide a single-cell characterization of cerebrospinal fluid and blood of newly diagnosed multiple sclerosis (MS) patients, revealing altered composition of lymphocyte and monocyte subsets, validated by other methods including the interrogation of the TFH subset in mouse models of MS.
url	https://doi.org/10.1038/s41467-019-14118-w
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Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis

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