| Summary: | <i>Pseudomonas aeruginosa</i> is the most common human opportunistic pathogen associated with nosocomial diseases. In 2017, the World Health Organization has classified <i>P. aeruginosa</i> as a critical agent threatening human health, and for which the development of new treatments is urgently necessary. One interesting avenue is to target virulence factors to understand <i>P. aeruginosa</i> pathogenicity. Thus, characterising exoproteins of <i>P. aeruginosa</i> is a hot research topic and proteomics is a powerful approach that provides important information to gain insights on bacterial virulence. The aim of this review is to focus on the contribution of proteomics to the studies of <i>P. aeruginosa</i> exoproteins, highlighting its relevance in the discovery of virulence factors, post-translational modifications on exoproteins and host-pathogen relationships.
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