Plasma Energy-Balance Metabolites Discriminate Asymptomatic Patients with Peripheral Artery Disease
Peripheral artery disease (PAD) is a common disease affecting 20–25% of population over 60 years old. Early diagnosis is difficult because symptoms only become evident in advanced stages of the disease. Inflammation, impaired metabolism, and mitochondrial dysfunction predispose to PAD, which is norm...
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doaj-2768a8fa100445d19adab491b01dd79e2020-11-24T22:06:43ZengHindawi LimitedMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/27602722760272Plasma Energy-Balance Metabolites Discriminate Asymptomatic Patients with Peripheral Artery DiseaseAnna Hernández-Aguilera0Salvador Fernández-Arroyo1Noemí Cabre2Fedra Luciano-Mateo3Gerard Baiges-Gaya4Montserrat Fibla5Vicente Martín-Paredero6Javier A. Menendez7Jordi Camps8Jorge Joven9Unitat de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut d’Investigació Sanitària Pere Virgili, C. Sant Joan s/n, 43201 Reus, SpainUniversitat Rovira i Virgili, C. Escorxador s/n, 43003 Tarragona, SpainUniversitat Rovira i Virgili, C. Escorxador s/n, 43003 Tarragona, SpainUniversitat Rovira i Virgili, C. Escorxador s/n, 43003 Tarragona, SpainUniversitat Rovira i Virgili, C. Escorxador s/n, 43003 Tarragona, SpainUnitat de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut d’Investigació Sanitària Pere Virgili, C. Sant Joan s/n, 43201 Reus, SpainDepartment of Vascular Surgery, Hospital Universitari Joan XXIII, C/ Dr. Mallafré Guasch 4, 43005 Tarragona, SpainProgram Against Cancer Therapeutic Resistance (ProCURE), Metabolism and Cancer Group, Catalan Institute of Oncology, Girona, SpainUnitat de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut d’Investigació Sanitària Pere Virgili, C. Sant Joan s/n, 43201 Reus, SpainUnitat de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut d’Investigació Sanitària Pere Virgili, C. Sant Joan s/n, 43201 Reus, SpainPeripheral artery disease (PAD) is a common disease affecting 20–25% of population over 60 years old. Early diagnosis is difficult because symptoms only become evident in advanced stages of the disease. Inflammation, impaired metabolism, and mitochondrial dysfunction predispose to PAD, which is normally associated with other highly prevalent and related conditions, such as diabetes, dyslipidemia, and hypertension. We have measured energy-balance-associated metabolite concentrations in the plasma of PAD patients segregated by the severity of the disease and in plasma of healthy volunteers using a quantitative and targeted metabolomic approach. We found relevant associations between several metabolites (3-hydroxybutirate, aconitate, (iso)citrate, glutamate, and serine) with markers of oxidative stress and inflammation. Metabolomic profiling also revealed that (iso)citrate and glutamate are metabolites with high ability to discriminate between healthy participants and PAD patients without symptoms. Collectively, our data suggest that metabolomics provide significant information on the pathogenesis of PAD and useful biomarkers for the diagnosis and assessment of progression.http://dx.doi.org/10.1155/2018/2760272 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anna Hernández-Aguilera Salvador Fernández-Arroyo Noemí Cabre Fedra Luciano-Mateo Gerard Baiges-Gaya Montserrat Fibla Vicente Martín-Paredero Javier A. Menendez Jordi Camps Jorge Joven |
spellingShingle |
Anna Hernández-Aguilera Salvador Fernández-Arroyo Noemí Cabre Fedra Luciano-Mateo Gerard Baiges-Gaya Montserrat Fibla Vicente Martín-Paredero Javier A. Menendez Jordi Camps Jorge Joven Plasma Energy-Balance Metabolites Discriminate Asymptomatic Patients with Peripheral Artery Disease Mediators of Inflammation |
author_facet |
Anna Hernández-Aguilera Salvador Fernández-Arroyo Noemí Cabre Fedra Luciano-Mateo Gerard Baiges-Gaya Montserrat Fibla Vicente Martín-Paredero Javier A. Menendez Jordi Camps Jorge Joven |
author_sort |
Anna Hernández-Aguilera |
title |
Plasma Energy-Balance Metabolites Discriminate Asymptomatic Patients with Peripheral Artery Disease |
title_short |
Plasma Energy-Balance Metabolites Discriminate Asymptomatic Patients with Peripheral Artery Disease |
title_full |
Plasma Energy-Balance Metabolites Discriminate Asymptomatic Patients with Peripheral Artery Disease |
title_fullStr |
Plasma Energy-Balance Metabolites Discriminate Asymptomatic Patients with Peripheral Artery Disease |
title_full_unstemmed |
Plasma Energy-Balance Metabolites Discriminate Asymptomatic Patients with Peripheral Artery Disease |
title_sort |
plasma energy-balance metabolites discriminate asymptomatic patients with peripheral artery disease |
publisher |
Hindawi Limited |
series |
Mediators of Inflammation |
issn |
0962-9351 1466-1861 |
publishDate |
2018-01-01 |
description |
Peripheral artery disease (PAD) is a common disease affecting 20–25% of population over 60 years old. Early diagnosis is difficult because symptoms only become evident in advanced stages of the disease. Inflammation, impaired metabolism, and mitochondrial dysfunction predispose to PAD, which is normally associated with other highly prevalent and related conditions, such as diabetes, dyslipidemia, and hypertension. We have measured energy-balance-associated metabolite concentrations in the plasma of PAD patients segregated by the severity of the disease and in plasma of healthy volunteers using a quantitative and targeted metabolomic approach. We found relevant associations between several metabolites (3-hydroxybutirate, aconitate, (iso)citrate, glutamate, and serine) with markers of oxidative stress and inflammation. Metabolomic profiling also revealed that (iso)citrate and glutamate are metabolites with high ability to discriminate between healthy participants and PAD patients without symptoms. Collectively, our data suggest that metabolomics provide significant information on the pathogenesis of PAD and useful biomarkers for the diagnosis and assessment of progression. |
url |
http://dx.doi.org/10.1155/2018/2760272 |
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