Alga Ecklonia bicyclis, Tribulus terrestris, and Glucosamine Oligosaccharide Improve Erectile Function, Sexual Quality of Life, and Ejaculation Function in Patients with Moderate Mild-Moderate Erectile Dysfunction: A Prospective, Randomized, Placebo-Controlled, Single-Blinded Study

Alga Ecklonia bicyclis, Tribulus terrestris, and Glucosamine Oligosaccharide Improve Erectile Function, Sexual Quality of Life, and Ejaculation Function in Patients with Moderate Mild-Moderate Erectile Dysfunction: A Prospective, Randomized, Placebo-Controlled, Single-Blinded Study

We aimed to evaluate the efficacy of oral therapy with alga Ecklonia bicyclis, Tribulus terrestris, and glucosamine oligosaccharide (Tradamix TX1000) in patients with erectile dysfunction (ED) at 3 months of follow-up. From January 2013 to September 2013, 177 patients diagnosed with mild-moderate ED...

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Main Authors: Salvatore Sansalone, Rosario Leonardi, Gabriele Antonini, Antonio Vitarelli, Giuseppe Vespasiani, Dragoslav Basic, Giuseppe Morgia, Sebastiano Cimino, Giorgio Ivan Russo
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2014/121396
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spelling doaj-276ba8686e184072b13eab9da88fb37d2020-11-25T00:57:20ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/121396121396Alga Ecklonia bicyclis, Tribulus terrestris, and Glucosamine Oligosaccharide Improve Erectile Function, Sexual Quality of Life, and Ejaculation Function in Patients with Moderate Mild-Moderate Erectile Dysfunction: A Prospective, Randomized, Placebo-Controlled, Single-Blinded StudySalvatore Sansalone0Rosario Leonardi1Gabriele Antonini2Antonio Vitarelli3Giuseppe Vespasiani4Dragoslav Basic5Giuseppe Morgia6Sebastiano Cimino7Giorgio Ivan Russo8Department of Experimental Medicine and Surgery, Tor Vergata University of Rome, Rome, ItalyCentro Uro Andrologico, Acireale, ItalyDepartment of Urology “U. Bracci”, La Sapienza University of Rome, Rome, ItalyUrologia Universitaria II, Azienda Ospedaliera Policlinico Bari, Bari, ItalyDepartment of Experimental Medicine and Surgery, Tor Vergata University of Rome, Rome, ItalyClinic of Urology, Clinical Center Nis, Nis, SerbiaSchool of Medicine Policlinico Hospital, Department of Urology, University of Catania, Catania, ItalySchool of Medicine Policlinico Hospital, Department of Urology, University of Catania, Catania, ItalySchool of Medicine Policlinico Hospital, Department of Urology, University of Catania, Catania, ItalyWe aimed to evaluate the efficacy of oral therapy with alga Ecklonia bicyclis, Tribulus terrestris, and glucosamine oligosaccharide (Tradamix TX1000) in patients with erectile dysfunction (ED) at 3 months of follow-up. From January 2013 to September 2013, 177 patients diagnosed with mild-moderate ED (IIEF-EF < 26) were enrolled in this multicenter, single-blinded, placebo-controlled study and randomized in Group A (Tradamix, n=87) and Group B (placebo, n=90). Penile color Doppler ultrasound measures, IIEF-15 questionnaire, male sexual health questionnaire-ejaculation disorder (MSHQ-EjD), and sexual quality of life (SQoL-M) were collected. We observed significant changes of the IIEF-15 in Group A (mean difference: 11.54; P<0.05) at 3 months versus Group B (P<0.05). PSV (P<0.05), IIEF-intercourse satisfaction (P<0.05), IIEF-orgasmic function (mean P<0.05), IIEF-sexual desire (P<0.05), IIEF-overall satisfaction (P<0.05), MSHQ-EjD (mean difference: 1.21; P<0.05), and SQoL-M (mean difference: 10.2; P<0.05) were significantly changed in Group A versus baseline and Group B. Patients with moderate arterial dysfunction showed significant increase of PSV (P<0.05), IIEF-EF (P<0.05), MSHQ-EjD (P<0.05), and SQoL-M (P<0.05) in Group A. Therapy with Tradamix improves erectile and ejaculation function and sexual quality of life in patients with mild-moderate ED and in particular for those with moderate arterial dysfunction.http://dx.doi.org/10.1155/2014/121396
collection DOAJ
language English
format Article
sources DOAJ
author Salvatore Sansalone
Rosario Leonardi
Gabriele Antonini
Antonio Vitarelli
Giuseppe Vespasiani
Dragoslav Basic
Giuseppe Morgia
Sebastiano Cimino
Giorgio Ivan Russo
spellingShingle Salvatore Sansalone
Rosario Leonardi
Gabriele Antonini
Antonio Vitarelli
Giuseppe Vespasiani
Dragoslav Basic
Giuseppe Morgia
Sebastiano Cimino
Giorgio Ivan Russo
Alga Ecklonia bicyclis, Tribulus terrestris, and Glucosamine Oligosaccharide Improve Erectile Function, Sexual Quality of Life, and Ejaculation Function in Patients with Moderate Mild-Moderate Erectile Dysfunction: A Prospective, Randomized, Placebo-Controlled, Single-Blinded Study
BioMed Research International
author_facet Salvatore Sansalone
Rosario Leonardi
Gabriele Antonini
Antonio Vitarelli
Giuseppe Vespasiani
Dragoslav Basic
Giuseppe Morgia
Sebastiano Cimino
Giorgio Ivan Russo
author_sort Salvatore Sansalone
title Alga Ecklonia bicyclis, Tribulus terrestris, and Glucosamine Oligosaccharide Improve Erectile Function, Sexual Quality of Life, and Ejaculation Function in Patients with Moderate Mild-Moderate Erectile Dysfunction: A Prospective, Randomized, Placebo-Controlled, Single-Blinded Study
title_short Alga Ecklonia bicyclis, Tribulus terrestris, and Glucosamine Oligosaccharide Improve Erectile Function, Sexual Quality of Life, and Ejaculation Function in Patients with Moderate Mild-Moderate Erectile Dysfunction: A Prospective, Randomized, Placebo-Controlled, Single-Blinded Study
title_full Alga Ecklonia bicyclis, Tribulus terrestris, and Glucosamine Oligosaccharide Improve Erectile Function, Sexual Quality of Life, and Ejaculation Function in Patients with Moderate Mild-Moderate Erectile Dysfunction: A Prospective, Randomized, Placebo-Controlled, Single-Blinded Study
title_fullStr Alga Ecklonia bicyclis, Tribulus terrestris, and Glucosamine Oligosaccharide Improve Erectile Function, Sexual Quality of Life, and Ejaculation Function in Patients with Moderate Mild-Moderate Erectile Dysfunction: A Prospective, Randomized, Placebo-Controlled, Single-Blinded Study
title_full_unstemmed Alga Ecklonia bicyclis, Tribulus terrestris, and Glucosamine Oligosaccharide Improve Erectile Function, Sexual Quality of Life, and Ejaculation Function in Patients with Moderate Mild-Moderate Erectile Dysfunction: A Prospective, Randomized, Placebo-Controlled, Single-Blinded Study
title_sort alga ecklonia bicyclis, tribulus terrestris, and glucosamine oligosaccharide improve erectile function, sexual quality of life, and ejaculation function in patients with moderate mild-moderate erectile dysfunction: a prospective, randomized, placebo-controlled, single-blinded study
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2014-01-01
description We aimed to evaluate the efficacy of oral therapy with alga Ecklonia bicyclis, Tribulus terrestris, and glucosamine oligosaccharide (Tradamix TX1000) in patients with erectile dysfunction (ED) at 3 months of follow-up. From January 2013 to September 2013, 177 patients diagnosed with mild-moderate ED (IIEF-EF < 26) were enrolled in this multicenter, single-blinded, placebo-controlled study and randomized in Group A (Tradamix, n=87) and Group B (placebo, n=90). Penile color Doppler ultrasound measures, IIEF-15 questionnaire, male sexual health questionnaire-ejaculation disorder (MSHQ-EjD), and sexual quality of life (SQoL-M) were collected. We observed significant changes of the IIEF-15 in Group A (mean difference: 11.54; P<0.05) at 3 months versus Group B (P<0.05). PSV (P<0.05), IIEF-intercourse satisfaction (P<0.05), IIEF-orgasmic function (mean P<0.05), IIEF-sexual desire (P<0.05), IIEF-overall satisfaction (P<0.05), MSHQ-EjD (mean difference: 1.21; P<0.05), and SQoL-M (mean difference: 10.2; P<0.05) were significantly changed in Group A versus baseline and Group B. Patients with moderate arterial dysfunction showed significant increase of PSV (P<0.05), IIEF-EF (P<0.05), MSHQ-EjD (P<0.05), and SQoL-M (P<0.05) in Group A. Therapy with Tradamix improves erectile and ejaculation function and sexual quality of life in patients with mild-moderate ED and in particular for those with moderate arterial dysfunction.
url http://dx.doi.org/10.1155/2014/121396
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