A comparative structural bioinformatics analysis of the insulin receptor family ectodomain based on phylogenetic information.
The insulin receptor (IR), the insulin-like growth factor 1 receptor (IGF1R) and the insulin receptor-related receptor (IRR) are covalently-linked homodimers made up of several structural domains. The molecular mechanism of ligand binding to the ectodomain of these receptors and the resulting activa...
Main Authors: | Miguel E Rentería, Neha S Gandhi, Pablo Vinuesa, Erik Helmerhorst, Ricardo L Mancera |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2008-01-01
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Series: | PLoS ONE |
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18989367/pdf/?tool=EBI |
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