Extracellular Vesicle-Dependent Cross-Talk in Cancer—Focus on Pancreatic Cancer
Extracellular vesicles (EVs) like exosomes and shed microvesicles are generated by many different cells. However, among all the cells, cancer cells are now recognized to secrete more EVs than healthy cells. Tumor-derived EVs can be isolated from biofluids such as blood, urine, ascitic fluid, and sal...
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2020-08-01
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doaj-277c619e7aea466693fbb902d8dce7b12020-11-25T03:23:36ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-08-011010.3389/fonc.2020.01456527418Extracellular Vesicle-Dependent Cross-Talk in Cancer—Focus on Pancreatic CancerLise Nannan0Lise Nannan1Lise Nannan2Jean-Baptiste Oudart3Jean-Baptiste Oudart4Jean-Baptiste Oudart5Jean Claude Monboisse6Jean Claude Monboisse7Jean Claude Monboisse8Laurent Ramont9Laurent Ramont10Laurent Ramont11Sylvie Brassart-Pasco12Sylvie Brassart-Pasco13Bertrand Brassart14Bertrand Brassart15Université de Reims Champagne Ardenne, SFR CAP-Santé (FED 4231), Laboratoire de Biochimie Médicale et Biologie Moléculaire, Reims, FranceCNRS UMR 7369, Matrice Extracellulaire et Dynamique Cellulaire–MEDyC, Reims, FranceBiomedical MRI Group, Department of Imaging and Pathology, KU Leuven, Leuven, BelgiumUniversité de Reims Champagne Ardenne, SFR CAP-Santé (FED 4231), Laboratoire de Biochimie Médicale et Biologie Moléculaire, Reims, FranceCNRS UMR 7369, Matrice Extracellulaire et Dynamique Cellulaire–MEDyC, Reims, FranceCHU Reims, Service de Biochimie–Pharmacologie–Toxicologie, Reims, FranceUniversité de Reims Champagne Ardenne, SFR CAP-Santé (FED 4231), Laboratoire de Biochimie Médicale et Biologie Moléculaire, Reims, FranceCNRS UMR 7369, Matrice Extracellulaire et Dynamique Cellulaire–MEDyC, Reims, FranceCHU Reims, Service de Biochimie–Pharmacologie–Toxicologie, Reims, FranceUniversité de Reims Champagne Ardenne, SFR CAP-Santé (FED 4231), Laboratoire de Biochimie Médicale et Biologie Moléculaire, Reims, FranceCNRS UMR 7369, Matrice Extracellulaire et Dynamique Cellulaire–MEDyC, Reims, FranceCHU Reims, Service de Biochimie–Pharmacologie–Toxicologie, Reims, FranceUniversité de Reims Champagne Ardenne, SFR CAP-Santé (FED 4231), Laboratoire de Biochimie Médicale et Biologie Moléculaire, Reims, FranceCNRS UMR 7369, Matrice Extracellulaire et Dynamique Cellulaire–MEDyC, Reims, FranceUniversité de Reims Champagne Ardenne, SFR CAP-Santé (FED 4231), Laboratoire de Biochimie Médicale et Biologie Moléculaire, Reims, FranceCNRS UMR 7369, Matrice Extracellulaire et Dynamique Cellulaire–MEDyC, Reims, FranceExtracellular vesicles (EVs) like exosomes and shed microvesicles are generated by many different cells. However, among all the cells, cancer cells are now recognized to secrete more EVs than healthy cells. Tumor-derived EVs can be isolated from biofluids such as blood, urine, ascitic fluid, and saliva. Their numerous components (nucleic acids, proteins, and lipids) possess many pleiotropic functions involved in cancer progression. The tumor-derived EVs generated under the influence of tumor microenvironment play distant roles and promote cellular communication by directly interacting with different cells. Moreover, they modulate extracellular matrix remodeling and tumor progression. Tumor-derived EVs are involved in pre-metastatic niche formation, dependent on the EV-associated protein receptors, and in cancer chemoresistance as they transfer drug-resistance-related genes to recipient cells. Recent advances in preclinical and clinical fields suggest their potential use as biomarkers for diagnosis and prognosis as well as for drug delivery in cancer. In this Review, we discuss EV characteristics and pro-tumor capacities, and highlight the future crucial impact of tumor-derived EVs in pancreatic cancer diagnosis and prognosis.https://www.frontiersin.org/article/10.3389/fonc.2020.01456/fullextracellular vesicle (EV)pancreatic cancerbiomarkersimaging in vivobioactivities |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lise Nannan Lise Nannan Lise Nannan Jean-Baptiste Oudart Jean-Baptiste Oudart Jean-Baptiste Oudart Jean Claude Monboisse Jean Claude Monboisse Jean Claude Monboisse Laurent Ramont Laurent Ramont Laurent Ramont Sylvie Brassart-Pasco Sylvie Brassart-Pasco Bertrand Brassart Bertrand Brassart |
spellingShingle |
Lise Nannan Lise Nannan Lise Nannan Jean-Baptiste Oudart Jean-Baptiste Oudart Jean-Baptiste Oudart Jean Claude Monboisse Jean Claude Monboisse Jean Claude Monboisse Laurent Ramont Laurent Ramont Laurent Ramont Sylvie Brassart-Pasco Sylvie Brassart-Pasco Bertrand Brassart Bertrand Brassart Extracellular Vesicle-Dependent Cross-Talk in Cancer—Focus on Pancreatic Cancer Frontiers in Oncology extracellular vesicle (EV) pancreatic cancer biomarkers imaging in vivo bioactivities |
author_facet |
Lise Nannan Lise Nannan Lise Nannan Jean-Baptiste Oudart Jean-Baptiste Oudart Jean-Baptiste Oudart Jean Claude Monboisse Jean Claude Monboisse Jean Claude Monboisse Laurent Ramont Laurent Ramont Laurent Ramont Sylvie Brassart-Pasco Sylvie Brassart-Pasco Bertrand Brassart Bertrand Brassart |
author_sort |
Lise Nannan |
title |
Extracellular Vesicle-Dependent Cross-Talk in Cancer—Focus on Pancreatic Cancer |
title_short |
Extracellular Vesicle-Dependent Cross-Talk in Cancer—Focus on Pancreatic Cancer |
title_full |
Extracellular Vesicle-Dependent Cross-Talk in Cancer—Focus on Pancreatic Cancer |
title_fullStr |
Extracellular Vesicle-Dependent Cross-Talk in Cancer—Focus on Pancreatic Cancer |
title_full_unstemmed |
Extracellular Vesicle-Dependent Cross-Talk in Cancer—Focus on Pancreatic Cancer |
title_sort |
extracellular vesicle-dependent cross-talk in cancer—focus on pancreatic cancer |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2020-08-01 |
description |
Extracellular vesicles (EVs) like exosomes and shed microvesicles are generated by many different cells. However, among all the cells, cancer cells are now recognized to secrete more EVs than healthy cells. Tumor-derived EVs can be isolated from biofluids such as blood, urine, ascitic fluid, and saliva. Their numerous components (nucleic acids, proteins, and lipids) possess many pleiotropic functions involved in cancer progression. The tumor-derived EVs generated under the influence of tumor microenvironment play distant roles and promote cellular communication by directly interacting with different cells. Moreover, they modulate extracellular matrix remodeling and tumor progression. Tumor-derived EVs are involved in pre-metastatic niche formation, dependent on the EV-associated protein receptors, and in cancer chemoresistance as they transfer drug-resistance-related genes to recipient cells. Recent advances in preclinical and clinical fields suggest their potential use as biomarkers for diagnosis and prognosis as well as for drug delivery in cancer. In this Review, we discuss EV characteristics and pro-tumor capacities, and highlight the future crucial impact of tumor-derived EVs in pancreatic cancer diagnosis and prognosis. |
topic |
extracellular vesicle (EV) pancreatic cancer biomarkers imaging in vivo bioactivities |
url |
https://www.frontiersin.org/article/10.3389/fonc.2020.01456/full |
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