Proteomics in Psoriasis
Psoriasis has been thought to be driven primarily by innate and adaptive immune systems that can be modified by genetic and environmental factors. Complex interplay between inflammatory cytokines and T-cells, especially Th1 and Th17 cells, leads to abnormal cell proliferation and psoriatic skin lesi...
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doaj-27835365fc6b4bad82682beb7a893f822020-11-24T22:20:20ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-03-01205114110.3390/ijms20051141ijms20051141Proteomics in PsoriasisLeena Chularojanamontri0Norramon Charoenpipatsin1Narumol Silpa-Archa2Chanisada Wongpraparut3Visith Thongboonkerd4Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandDepartment of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandDepartment of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandDepartment of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandMedical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandPsoriasis has been thought to be driven primarily by innate and adaptive immune systems that can be modified by genetic and environmental factors. Complex interplay between inflammatory cytokines and T-cells, especially Th1 and Th17 cells, leads to abnormal cell proliferation and psoriatic skin lesions. Nevertheless, such mechanisms do not entirely represent the pathogenesis of psoriasis. Moreover, earlier and better biomarkers in diagnostics, prognostics, and monitoring therapeutic outcomes of psoriasis are still needed. During the last two decades, proteomics (a systematic analysis of proteins for their identities, quantities, and functions) has been widely employed to psoriatic research. This review summarizes and discusses all of the previous studies that applied various modalities of proteomics technologies to psoriatic skin disease. The data obtained from such studies have led to (i) novel mechanisms and new hypotheses of the disease pathogenesis; (ii) biomarker discovery for diagnostics and prognostics; and (iii) proteome profiling for monitoring treatment efficacy and drug-induced toxicities.http://www.mdpi.com/1422-0067/20/5/1141biomarker discoverydermatologydiagnosticsprognosticsmass spectrometryproteomepsoriatic skin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Leena Chularojanamontri Norramon Charoenpipatsin Narumol Silpa-Archa Chanisada Wongpraparut Visith Thongboonkerd |
spellingShingle |
Leena Chularojanamontri Norramon Charoenpipatsin Narumol Silpa-Archa Chanisada Wongpraparut Visith Thongboonkerd Proteomics in Psoriasis International Journal of Molecular Sciences biomarker discovery dermatology diagnostics prognostics mass spectrometry proteome psoriatic skin |
author_facet |
Leena Chularojanamontri Norramon Charoenpipatsin Narumol Silpa-Archa Chanisada Wongpraparut Visith Thongboonkerd |
author_sort |
Leena Chularojanamontri |
title |
Proteomics in Psoriasis |
title_short |
Proteomics in Psoriasis |
title_full |
Proteomics in Psoriasis |
title_fullStr |
Proteomics in Psoriasis |
title_full_unstemmed |
Proteomics in Psoriasis |
title_sort |
proteomics in psoriasis |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2019-03-01 |
description |
Psoriasis has been thought to be driven primarily by innate and adaptive immune systems that can be modified by genetic and environmental factors. Complex interplay between inflammatory cytokines and T-cells, especially Th1 and Th17 cells, leads to abnormal cell proliferation and psoriatic skin lesions. Nevertheless, such mechanisms do not entirely represent the pathogenesis of psoriasis. Moreover, earlier and better biomarkers in diagnostics, prognostics, and monitoring therapeutic outcomes of psoriasis are still needed. During the last two decades, proteomics (a systematic analysis of proteins for their identities, quantities, and functions) has been widely employed to psoriatic research. This review summarizes and discusses all of the previous studies that applied various modalities of proteomics technologies to psoriatic skin disease. The data obtained from such studies have led to (i) novel mechanisms and new hypotheses of the disease pathogenesis; (ii) biomarker discovery for diagnostics and prognostics; and (iii) proteome profiling for monitoring treatment efficacy and drug-induced toxicities. |
topic |
biomarker discovery dermatology diagnostics prognostics mass spectrometry proteome psoriatic skin |
url |
http://www.mdpi.com/1422-0067/20/5/1141 |
work_keys_str_mv |
AT leenachularojanamontri proteomicsinpsoriasis AT norramoncharoenpipatsin proteomicsinpsoriasis AT narumolsilpaarcha proteomicsinpsoriasis AT chanisadawongpraparut proteomicsinpsoriasis AT visiththongboonkerd proteomicsinpsoriasis |
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