The importance of immunophenotyping by flow cytometry in distinction between hematogones and B lymphoblasts
Hematogones are normal B-lineage lymphoid precursors in the bone marrow. B lymphoblasts are immature neoplastic cells present in patients with precursor B-cell acute lymphoblastic leukemia (B-ALL). Hematogones and B lymphoblasts share characteristics, such as morphological similarity often indistinc...
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Sociedade Brasileira de Patologia Clínica
2015-02-01
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doaj-2789a665273345fc99f3dcd61f2fc0ac2020-11-25T02:47:15ZengSociedade Brasileira de Patologia ClínicaJornal Brasileiro de Patologia e Medicina Laboratorial1678-47742015-02-0151171210.5935/1676-2444.20150002S1676-24442015000100007The importance of immunophenotyping by flow cytometry in distinction between hematogones and B lymphoblastsAline B. WohlfahrtLaura HannelLiliane Z. OliveiraPâmela B. SoaresJosé Edson P. SilvaHematogones are normal B-lineage lymphoid precursors in the bone marrow. B lymphoblasts are immature neoplastic cells present in patients with precursor B-cell acute lymphoblastic leukemia (B-ALL). Hematogones and B lymphoblasts share characteristics, such as morphological similarity often indistinct and expression of the same antigens in immunophenotypic analysis. Increased numbers of hematogones in patients with B-ALL during regeneration of bone marrow after treatment for leukemia, in cases of disease relapse or marrow transplantation, may be subject to questions about the nature and prognosis of this immature cell. This article presents information about the morphological and immunophenotypic characteristics of B lymphoid precursors and verifies the relevance of immunophenotyping by flow cytometry (FC) in the distinction between those cells. This differentiation is essential to establish a correct prognosis and assist in medical decision about the most appropriate therapeutic scheme.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442015000100007&lng=en&tlng=enhematogôniaslinfoblastos Bleucemia linfoblástica agudacitometria de fluxoimunofenotipagem |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aline B. Wohlfahrt Laura Hannel Liliane Z. Oliveira Pâmela B. Soares José Edson P. Silva |
spellingShingle |
Aline B. Wohlfahrt Laura Hannel Liliane Z. Oliveira Pâmela B. Soares José Edson P. Silva The importance of immunophenotyping by flow cytometry in distinction between hematogones and B lymphoblasts Jornal Brasileiro de Patologia e Medicina Laboratorial hematogônias linfoblastos B leucemia linfoblástica aguda citometria de fluxo imunofenotipagem |
author_facet |
Aline B. Wohlfahrt Laura Hannel Liliane Z. Oliveira Pâmela B. Soares José Edson P. Silva |
author_sort |
Aline B. Wohlfahrt |
title |
The importance of immunophenotyping by flow cytometry in distinction between hematogones and B lymphoblasts |
title_short |
The importance of immunophenotyping by flow cytometry in distinction between hematogones and B lymphoblasts |
title_full |
The importance of immunophenotyping by flow cytometry in distinction between hematogones and B lymphoblasts |
title_fullStr |
The importance of immunophenotyping by flow cytometry in distinction between hematogones and B lymphoblasts |
title_full_unstemmed |
The importance of immunophenotyping by flow cytometry in distinction between hematogones and B lymphoblasts |
title_sort |
importance of immunophenotyping by flow cytometry in distinction between hematogones and b lymphoblasts |
publisher |
Sociedade Brasileira de Patologia Clínica |
series |
Jornal Brasileiro de Patologia e Medicina Laboratorial |
issn |
1678-4774 |
publishDate |
2015-02-01 |
description |
Hematogones are normal B-lineage lymphoid precursors in the bone marrow. B lymphoblasts are immature neoplastic cells present in patients with precursor B-cell acute lymphoblastic leukemia (B-ALL). Hematogones and B lymphoblasts share characteristics, such as morphological similarity often indistinct and expression of the same antigens in immunophenotypic analysis. Increased numbers of hematogones in patients with B-ALL during regeneration of bone marrow after treatment for leukemia, in cases of disease relapse or marrow transplantation, may be subject to questions about the nature and prognosis of this immature cell. This article presents information about the morphological and immunophenotypic characteristics of B lymphoid precursors and verifies the relevance of immunophenotyping by flow cytometry (FC) in the distinction between those cells. This differentiation is essential to establish a correct prognosis and assist in medical decision about the most appropriate therapeutic scheme. |
topic |
hematogônias linfoblastos B leucemia linfoblástica aguda citometria de fluxo imunofenotipagem |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442015000100007&lng=en&tlng=en |
work_keys_str_mv |
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