Clinical observation of glaucoma trabeculectomy with mitomycin C treatment

• Main Authors: Shi Liu, Shu-Hui Xing
• Format: Article
• Language: English
• Published: Press of International Journal of Ophthalmology (IJO PRESS) 2014-12-01
• Series: Guoji Yanke Zazhi
• Subjects: glaucoma; trabeculectomy; mitomycin C
• Online Access: http://ies.ijo.cn/cn_publish/2014/12/201412043.pdf
• ISSN: 1672-5123; 1672-5123

AIM:To explore the clinical outcome of trabeculectomy with mitomycin C(MMC)on glaucoma. <p>METHODS: A total of 57 patients(95 eyes)of primary glaucoma were randomly divided into two groups, 31 patients(54 eyes)in trabeculectomy with MMC(T+MMC)group, which received trabeculectomy with 0.2mg/mL MMC in surgical sites, and 26 patients(41 eyes)in trabeculectomy(T)group. The anterior chamber, bleb, intraocular pressure(IOP)and complications were observed. The post-operative follow-up periods ranged between 4 and 6mo.<p>RESULTS: The mean IOP was 11.24±3.73mmHg on 1d in group T+MMC. There was the significant difference compared with preoperative IOP(<i>P</i><0.01), while no difference with the group T(<i>P</i>>0.05). At final follow-up, the IOP was significantly different between group T+MMC and group T(16.15±3.62mmHg <i>vs</i> 18.79±5.27mmHg, <i>P</i><0.05). The rate of bleb formation was 94.44% and 80.48% in group T+MMC and T, respectively(<i>P</i><0.01). The postoperative complications were seldom, hyphema and corneal edema, and were cured finally.<p>CONCLUSION: Trabeculectomy with MMC for glaucoma can effectively reduce postoperative scar formation of the filtration passage and lower the IOP to a target level with fewer complications.