Micro RNA Molecules as Modulators of Treatment Resistance, Immune Checkpoints Controllers and Sensitive Biomarkers in Glioblastoma Multiforme
Based on genome sequencing, it is estimated that over 90% of genes stored in human genetic material are transcribed, but only 3% of them contain the information needed for the production of body proteins. This group also includes micro RNAs representing about 1%−3% of the human genome. Rec...
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MDPI AG
2020-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/4/1507 |
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doaj-27951461cbfe4fd8b0ea17db081886642020-11-25T00:42:12ZengMDPI AGInternational Journal of Molecular Sciences1422-00672020-02-01214150710.3390/ijms21041507ijms21041507Micro RNA Molecules as Modulators of Treatment Resistance, Immune Checkpoints Controllers and Sensitive Biomarkers in Glioblastoma MultiformeMarek Mazurek0Jakub Litak1Piotr Kamieniak2Ida Osuchowska3Ryszard Maciejewski4Jacek Roliński5Wiesława Grajkowska6Cezary Grochowski7Department of Neurosurgery and Pediatric Neurosurgery, Medical University of Lublin, Jaczewskiego 8, 20-954 Lublin, PolandDepartment of Neurosurgery and Pediatric Neurosurgery, Medical University of Lublin, Jaczewskiego 8, 20-954 Lublin, PolandDepartment of Neurosurgery and Pediatric Neurosurgery, Medical University of Lublin, Jaczewskiego 8, 20-954 Lublin, PolandDepartment of Anatomy, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, PolandDepartment of Anatomy, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, PolandDepartment of Immunology, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, PolandDepartment of Oncopathology and Biostructure, „Pomnik-Centrum Zdrowia Dziecka” Institute, Al. Dzieci Polskich 20, 04-730 Warsaw, PolandDepartment of Anatomy, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, PolandBased on genome sequencing, it is estimated that over 90% of genes stored in human genetic material are transcribed, but only 3% of them contain the information needed for the production of body proteins. This group also includes micro RNAs representing about 1%−3% of the human genome. Recent studies confirmed the hypothesis that targeting molecules called Immune Checkpoint (IC) open new opportunities to take control over glioblastoma multiforme (GBM). Detection of markers that indicate the presence of the cancer occupies a very important place in modern oncology. This function can be performed by both the cancer cells themselves as well as their components and other substances detected in the patients’ bodies. Efforts have been made for many years to find a suitable marker useful in the diagnosis and monitoring of gliomas, including glioblastoma.https://www.mdpi.com/1422-0067/21/4/1507micro rnaglioblastoma multiformeimmune checkpointsgliomatumor |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Marek Mazurek Jakub Litak Piotr Kamieniak Ida Osuchowska Ryszard Maciejewski Jacek Roliński Wiesława Grajkowska Cezary Grochowski |
| spellingShingle |
Marek Mazurek Jakub Litak Piotr Kamieniak Ida Osuchowska Ryszard Maciejewski Jacek Roliński Wiesława Grajkowska Cezary Grochowski Micro RNA Molecules as Modulators of Treatment Resistance, Immune Checkpoints Controllers and Sensitive Biomarkers in Glioblastoma Multiforme International Journal of Molecular Sciences micro rna glioblastoma multiforme immune checkpoints glioma tumor |
| author_facet |
Marek Mazurek Jakub Litak Piotr Kamieniak Ida Osuchowska Ryszard Maciejewski Jacek Roliński Wiesława Grajkowska Cezary Grochowski |
| author_sort |
Marek Mazurek |
| title |
Micro RNA Molecules as Modulators of Treatment Resistance, Immune Checkpoints Controllers and Sensitive Biomarkers in Glioblastoma Multiforme |
| title_short |
Micro RNA Molecules as Modulators of Treatment Resistance, Immune Checkpoints Controllers and Sensitive Biomarkers in Glioblastoma Multiforme |
| title_full |
Micro RNA Molecules as Modulators of Treatment Resistance, Immune Checkpoints Controllers and Sensitive Biomarkers in Glioblastoma Multiforme |
| title_fullStr |
Micro RNA Molecules as Modulators of Treatment Resistance, Immune Checkpoints Controllers and Sensitive Biomarkers in Glioblastoma Multiforme |
| title_full_unstemmed |
Micro RNA Molecules as Modulators of Treatment Resistance, Immune Checkpoints Controllers and Sensitive Biomarkers in Glioblastoma Multiforme |
| title_sort |
micro rna molecules as modulators of treatment resistance, immune checkpoints controllers and sensitive biomarkers in glioblastoma multiforme |
| publisher |
MDPI AG |
| series |
International Journal of Molecular Sciences |
| issn |
1422-0067 |
| publishDate |
2020-02-01 |
| description |
Based on genome sequencing, it is estimated that over 90% of genes stored in human genetic material are transcribed, but only 3% of them contain the information needed for the production of body proteins. This group also includes micro RNAs representing about 1%−3% of the human genome. Recent studies confirmed the hypothesis that targeting molecules called Immune Checkpoint (IC) open new opportunities to take control over glioblastoma multiforme (GBM). Detection of markers that indicate the presence of the cancer occupies a very important place in modern oncology. This function can be performed by both the cancer cells themselves as well as their components and other substances detected in the patients’ bodies. Efforts have been made for many years to find a suitable marker useful in the diagnosis and monitoring of gliomas, including glioblastoma. |
| topic |
micro rna glioblastoma multiforme immune checkpoints glioma tumor |
| url |
https://www.mdpi.com/1422-0067/21/4/1507 |
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