Effect of Vitamin A, C and zinc Supplementations on Oxidant-Antioxidant and Clinical Indices in Rheumatoid Arthritis Patients: A Randomized Control Trial

• Main Authors: S Athari Nik Azm, MR Vafa, I Nourmohammadi, A Bidari, A Hoshyarrad, SH Jazayeri, F Hoseini, M Fasihi Radmandi
• Format: Article
• Language: fas
• Published: Tehran University of Medical Sciences 2009-12-01
• Series: مجله اپیدمیولوژی ایران
• Subjects: Rheumatoid arthritis; Oxidative stress; Antioxidants
• Online Access: http://irje.tums.ac.ir/browse.php?a_code=A-10-25-105&slc_lang=en&sid=1
• ISSN: 1735-7489; 2228-7507

Background & Objectives: oxygen free radicals have been implicated as mediators of tissue damage in RA patients. This study was aimed to find the effects of vitamin A, C and zinc supplementations on oxidant–antioxidant, inflammatory and clinical indices in inactive RA patients.Methods: We designed a randomized controlled trial. Forty nine (49) patients were randomly allocated in two groups; group I received their conventional treatment plus 300 mg vitamin C, 5 mg Zinc daily and 25000 IU vitamin A every other day for 12 weeks, group II received their conventional treatment only for the same duration. Disease activity (using the rheumatoid arthritis disease activity index (RADAI) score), biochemical indices [malondialdehyde (MDA), total antioxidant capacity (TAC)] and inflammatory markers [erythrocyte sedimentation rate (ESR), c-reactive protein (CRP)] was evaluated before and after 12 weeks. Results: Serum concentration of MDA and RADAI score (P<0.0001) and ESR (P=0.033) were significantly decreased and TAC levels (P<0.0001) were significantly increased in the first group in comparison to second group after 12 weeks. However, there were no statistically significant differences in serum CRP concentration of two groups (P>0.05). Conclusions: This study indicates that adding antioxidants as supplementations with conventional medications in inactive RA patients plays an important role in improving oxidative stress and decreasing disease activity and inflammatory status.