Neural population dynamics in human motor cortex during movements in people with ALS
The prevailing view of motor cortex holds that motor cortical neural activity represents muscle or movement parameters. However, recent studies in non-human primates have shown that neural activity does not simply represent muscle or movement parameters; instead, its temporal structure is well-descr...
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eLife Sciences Publications Ltd
2015-06-01
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| Online Access: | https://elifesciences.org/articles/07436 |
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doaj-279a4440be0c49959813d7da1298e9df2021-05-04T23:53:08ZengeLife Sciences Publications LtdeLife2050-084X2015-06-01410.7554/eLife.07436Neural population dynamics in human motor cortex during movements in people with ALSChethan Pandarinath0https://orcid.org/0000-0003-1241-1432Vikash Gilja1Christine H Blabe2Paul Nuyujukian3https://orcid.org/0000-0001-7778-5473Anish A Sarma4https://orcid.org/0000-0003-1261-0589Brittany L Sorice5Emad N Eskandar6Leigh R Hochberg7https://orcid.org/0000-0003-0261-2273Jaimie M Henderson8https://orcid.org/0000-0002-3276-2267Krishna V Shenoy9https://orcid.org/0000-0003-1534-9240Department of Neurosurgery, Stanford University, Stanford, United States; Department of Electrical Engineering, Stanford University, Stanford, United States; Stanford Neurosciences Institute, Stanford University, Stanford, United StatesDepartment of Neurosurgery, Stanford University, Stanford, United States; Department of Electrical Engineering, Stanford University, Stanford, United States; School of Engineering, Brown University, Providence, United StatesDepartment of Neurosurgery, Stanford University, Stanford, United StatesDepartment of Neurosurgery, Stanford University, Stanford, United States; Department of Electrical Engineering, Stanford University, Stanford, United States; Stanford Neurosciences Institute, Stanford University, Stanford, United StatesSchool of Engineering, Brown University, Providence, United States; Center for Neurorestoration and Neurotechnology, Rehabilitation R and D Service, Department of VA Medical Center, Providence, United States; Neurology, Massachusetts General Hospital, Boston, United States; Institute for Brain Science, Brown University, Providence, United StatesNeurology, Massachusetts General Hospital, Boston, United StatesDepartment of Neurosurgery, Harvard Medical School, Boston, United States; Department of Neurosurgery, Massachusetts General Hospital, Boston, United StatesCenter for Neurorestoration and Neurotechnology, Rehabilitation R and D Service, Department of VA Medical Center, Providence, United States; School of Engineering, Brown University, Providence, United States; Neurology, Massachusetts General Hospital, Boston, United States; Institute for Brain Science, Brown University, Providence, United States; Neurology, Harvard Medical School, Boston, United StatesDepartment of Neurosurgery, Stanford University, Stanford, United States; Stanford Neurosciences Institute, Stanford University, Stanford, United StatesDepartment of Electrical Engineering, Stanford University, Stanford, United States; Stanford Neurosciences Institute, Stanford University, Stanford, United States; Department of Neurobiology, Stanford University, Stanford, United States; Department of Bioengineering, Stanford University, Stanford, United States; Neurosciences Program, Stanford, United StatesThe prevailing view of motor cortex holds that motor cortical neural activity represents muscle or movement parameters. However, recent studies in non-human primates have shown that neural activity does not simply represent muscle or movement parameters; instead, its temporal structure is well-described by a dynamical system where activity during movement evolves lawfully from an initial pre-movement state. In this study, we analyze neuronal ensemble activity in motor cortex in two clinical trial participants diagnosed with Amyotrophic Lateral Sclerosis (ALS). We find that activity in human motor cortex has similar dynamical structure to that of non-human primates, indicating that human motor cortex contains a similar underlying dynamical system for movement generation. Clinical trial registration: NCT00912041.https://elifesciences.org/articles/07436motor controldynamical systemcomputational neurosciencemotor cortex |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Chethan Pandarinath Vikash Gilja Christine H Blabe Paul Nuyujukian Anish A Sarma Brittany L Sorice Emad N Eskandar Leigh R Hochberg Jaimie M Henderson Krishna V Shenoy |
| spellingShingle |
Chethan Pandarinath Vikash Gilja Christine H Blabe Paul Nuyujukian Anish A Sarma Brittany L Sorice Emad N Eskandar Leigh R Hochberg Jaimie M Henderson Krishna V Shenoy Neural population dynamics in human motor cortex during movements in people with ALS eLife motor control dynamical system computational neuroscience motor cortex |
| author_facet |
Chethan Pandarinath Vikash Gilja Christine H Blabe Paul Nuyujukian Anish A Sarma Brittany L Sorice Emad N Eskandar Leigh R Hochberg Jaimie M Henderson Krishna V Shenoy |
| author_sort |
Chethan Pandarinath |
| title |
Neural population dynamics in human motor cortex during movements in people with ALS |
| title_short |
Neural population dynamics in human motor cortex during movements in people with ALS |
| title_full |
Neural population dynamics in human motor cortex during movements in people with ALS |
| title_fullStr |
Neural population dynamics in human motor cortex during movements in people with ALS |
| title_full_unstemmed |
Neural population dynamics in human motor cortex during movements in people with ALS |
| title_sort |
neural population dynamics in human motor cortex during movements in people with als |
| publisher |
eLife Sciences Publications Ltd |
| series |
eLife |
| issn |
2050-084X |
| publishDate |
2015-06-01 |
| description |
The prevailing view of motor cortex holds that motor cortical neural activity represents muscle or movement parameters. However, recent studies in non-human primates have shown that neural activity does not simply represent muscle or movement parameters; instead, its temporal structure is well-described by a dynamical system where activity during movement evolves lawfully from an initial pre-movement state. In this study, we analyze neuronal ensemble activity in motor cortex in two clinical trial participants diagnosed with Amyotrophic Lateral Sclerosis (ALS). We find that activity in human motor cortex has similar dynamical structure to that of non-human primates, indicating that human motor cortex contains a similar underlying dynamical system for movement generation.
Clinical trial registration: NCT00912041. |
| topic |
motor control dynamical system computational neuroscience motor cortex |
| url |
https://elifesciences.org/articles/07436 |
| work_keys_str_mv |
AT chethanpandarinath neuralpopulationdynamicsinhumanmotorcortexduringmovementsinpeoplewithals AT vikashgilja neuralpopulationdynamicsinhumanmotorcortexduringmovementsinpeoplewithals AT christinehblabe neuralpopulationdynamicsinhumanmotorcortexduringmovementsinpeoplewithals AT paulnuyujukian neuralpopulationdynamicsinhumanmotorcortexduringmovementsinpeoplewithals AT anishasarma neuralpopulationdynamicsinhumanmotorcortexduringmovementsinpeoplewithals AT brittanylsorice neuralpopulationdynamicsinhumanmotorcortexduringmovementsinpeoplewithals AT emadneskandar neuralpopulationdynamicsinhumanmotorcortexduringmovementsinpeoplewithals AT leighrhochberg neuralpopulationdynamicsinhumanmotorcortexduringmovementsinpeoplewithals AT jaimiemhenderson neuralpopulationdynamicsinhumanmotorcortexduringmovementsinpeoplewithals AT krishnavshenoy neuralpopulationdynamicsinhumanmotorcortexduringmovementsinpeoplewithals |
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1721476702523097088 |