siRNA Treatment: “A Sword-in-the-Stone” for Acute Brain Injuries

Ever since the discovery of small interfering ribonucleic acid (siRNA) a little over a decade ago, it has been highly sought after for its potential as a therapeutic agent for many diseases. In this review, we discuss the promising possibility of siRNA to be used as a drug to treat acute brain injur...

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Bibliographic Details
Main Authors:	Jerome Badaut, Andrew M. Fukuda
Format:	Article
Language:	English
Published:	MDPI AG 2013-09-01
Series:	Genes
Subjects:	brain siRNA RNAi traumatic brain injury stroke ischemia subarachnoid hemorrhage
Online Access:	http://www.mdpi.com/2073-4425/4/3/435

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spelling	doaj-279a53f25eec422a8fe62a6adbfebb162020-11-24T20:56:14ZengMDPI AGGenes2073-44252013-09-014343545610.3390/genes4030435siRNA Treatment: “A Sword-in-the-Stone” for Acute Brain InjuriesJerome BadautAndrew M. FukudaEver since the discovery of small interfering ribonucleic acid (siRNA) a little over a decade ago, it has been highly sought after for its potential as a therapeutic agent for many diseases. In this review, we discuss the promising possibility of siRNA to be used as a drug to treat acute brain injuries such as stroke and traumatic brain injury. First, we will give a brief and basic overview of the principle of RNA interference as an effective mechanism to decrease specific protein expression. Then, we will review recent in vivo studies describing siRNA research experiments/treatment options for acute brain diseases. Lastly, we will discuss the future of siRNA as a clinical therapeutic strategy against brain diseases and injuries, while addressing the current obstacles to effective brain delivery.http://www.mdpi.com/2073-4425/4/3/435brainsiRNARNAitraumatic brain injurystrokeischemiasubarachnoid hemorrhage
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jerome Badaut Andrew M. Fukuda
spellingShingle	Jerome Badaut Andrew M. Fukuda siRNA Treatment: “A Sword-in-the-Stone” for Acute Brain Injuries Genes brain siRNA RNAi traumatic brain injury stroke ischemia subarachnoid hemorrhage
author_facet	Jerome Badaut Andrew M. Fukuda
author_sort	Jerome Badaut
title	siRNA Treatment: “A Sword-in-the-Stone” for Acute Brain Injuries
title_short	siRNA Treatment: “A Sword-in-the-Stone” for Acute Brain Injuries
title_full	siRNA Treatment: “A Sword-in-the-Stone” for Acute Brain Injuries
title_fullStr	siRNA Treatment: “A Sword-in-the-Stone” for Acute Brain Injuries
title_full_unstemmed	siRNA Treatment: “A Sword-in-the-Stone” for Acute Brain Injuries
title_sort	sirna treatment: “a sword-in-the-stone” for acute brain injuries
publisher	MDPI AG
series	Genes
issn	2073-4425
publishDate	2013-09-01
description	Ever since the discovery of small interfering ribonucleic acid (siRNA) a little over a decade ago, it has been highly sought after for its potential as a therapeutic agent for many diseases. In this review, we discuss the promising possibility of siRNA to be used as a drug to treat acute brain injuries such as stroke and traumatic brain injury. First, we will give a brief and basic overview of the principle of RNA interference as an effective mechanism to decrease specific protein expression. Then, we will review recent in vivo studies describing siRNA research experiments/treatment options for acute brain diseases. Lastly, we will discuss the future of siRNA as a clinical therapeutic strategy against brain diseases and injuries, while addressing the current obstacles to effective brain delivery.
topic	brain siRNA RNAi traumatic brain injury stroke ischemia subarachnoid hemorrhage
url	http://www.mdpi.com/2073-4425/4/3/435
work_keys_str_mv	AT jeromebadaut sirnatreatmentaswordinthestoneforacutebraininjuries AT andrewmfukuda sirnatreatmentaswordinthestoneforacutebraininjuries
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siRNA Treatment: “A Sword-in-the-Stone” for Acute Brain Injuries

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