siRNA Treatment: “A Sword-in-the-Stone” for Acute Brain Injuries
Ever since the discovery of small interfering ribonucleic acid (siRNA) a little over a decade ago, it has been highly sought after for its potential as a therapeutic agent for many diseases. In this review, we discuss the promising possibility of siRNA to be used as a drug to treat acute brain injur...
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2013-09-01
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Online Access: | http://www.mdpi.com/2073-4425/4/3/435 |
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doaj-279a53f25eec422a8fe62a6adbfebb162020-11-24T20:56:14ZengMDPI AGGenes2073-44252013-09-014343545610.3390/genes4030435siRNA Treatment: “A Sword-in-the-Stone” for Acute Brain InjuriesJerome BadautAndrew M. FukudaEver since the discovery of small interfering ribonucleic acid (siRNA) a little over a decade ago, it has been highly sought after for its potential as a therapeutic agent for many diseases. In this review, we discuss the promising possibility of siRNA to be used as a drug to treat acute brain injuries such as stroke and traumatic brain injury. First, we will give a brief and basic overview of the principle of RNA interference as an effective mechanism to decrease specific protein expression. Then, we will review recent in vivo studies describing siRNA research experiments/treatment options for acute brain diseases. Lastly, we will discuss the future of siRNA as a clinical therapeutic strategy against brain diseases and injuries, while addressing the current obstacles to effective brain delivery.http://www.mdpi.com/2073-4425/4/3/435brainsiRNARNAitraumatic brain injurystrokeischemiasubarachnoid hemorrhage |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jerome Badaut Andrew M. Fukuda |
spellingShingle |
Jerome Badaut Andrew M. Fukuda siRNA Treatment: “A Sword-in-the-Stone” for Acute Brain Injuries Genes brain siRNA RNAi traumatic brain injury stroke ischemia subarachnoid hemorrhage |
author_facet |
Jerome Badaut Andrew M. Fukuda |
author_sort |
Jerome Badaut |
title |
siRNA Treatment: “A Sword-in-the-Stone” for Acute Brain Injuries |
title_short |
siRNA Treatment: “A Sword-in-the-Stone” for Acute Brain Injuries |
title_full |
siRNA Treatment: “A Sword-in-the-Stone” for Acute Brain Injuries |
title_fullStr |
siRNA Treatment: “A Sword-in-the-Stone” for Acute Brain Injuries |
title_full_unstemmed |
siRNA Treatment: “A Sword-in-the-Stone” for Acute Brain Injuries |
title_sort |
sirna treatment: “a sword-in-the-stone” for acute brain injuries |
publisher |
MDPI AG |
series |
Genes |
issn |
2073-4425 |
publishDate |
2013-09-01 |
description |
Ever since the discovery of small interfering ribonucleic acid (siRNA) a little over a decade ago, it has been highly sought after for its potential as a therapeutic agent for many diseases. In this review, we discuss the promising possibility of siRNA to be used as a drug to treat acute brain injuries such as stroke and traumatic brain injury. First, we will give a brief and basic overview of the principle of RNA interference as an effective mechanism to decrease specific protein expression. Then, we will review recent in vivo studies describing siRNA research experiments/treatment options for acute brain diseases. Lastly, we will discuss the future of siRNA as a clinical therapeutic strategy against brain diseases and injuries, while addressing the current obstacles to effective brain delivery. |
topic |
brain siRNA RNAi traumatic brain injury stroke ischemia subarachnoid hemorrhage |
url |
http://www.mdpi.com/2073-4425/4/3/435 |
work_keys_str_mv |
AT jeromebadaut sirnatreatmentaswordinthestoneforacutebraininjuries AT andrewmfukuda sirnatreatmentaswordinthestoneforacutebraininjuries |
_version_ |
1716790310293471232 |