Effect of Chitin Nanofibrils on Biocompatibility and Bioactivity of the Chitosan-Based Composite Film Matrix Intended for Tissue Engineering

Effect of Chitin Nanofibrils on Biocompatibility and Bioactivity of the Chitosan-Based Composite Film Matrix Intended for Tissue Engineering

This paper discusses the mechanical and physicochemical properties of film matrices based on chitosan, as well as the possibility of optimizing these properties by adding chitin nanofibrils. It is shown that with the introduction of chitin nanofibrils as a filler, the mechanical stability of the com...

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Bibliographic Details
Main Authors: Natalia V. Smirnova, Konstantin A. Kolbe, Elena N. Dresvyanina, Sergey F. Grebennikov, Irina P. Dobrovolskaya, Vladimir E. Yudin, Thomas Luxbacher, Pierfrancesco Morganti
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Materials
Subjects:
chitosan
chitin nanofibrils
composite matrix
tissue engineering
Online Access:https://www.mdpi.com/1996-1944/12/11/1874
Description
Summary:This paper discusses the mechanical and physicochemical properties of film matrices based on chitosan, as well as the possibility of optimizing these properties by adding chitin nanofibrils. It is shown that with the introduction of chitin nanofibrils as a filler, the mechanical stability of the composite materials increases. By varying the concentration of chitin nanofibrils, it is possible to obtain a spectrum of samples with different bioactive properties for the growth of human dermal fibroblasts. Film matrices based on the nanocomposite of chitosan and 5 wt % chitin nanofibrils have an optimal balance of mechanical and physicochemical properties and bioactivity in relation to the culture of human dermal fibroblasts.
ISSN:1996-1944

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