The BH3 only Bcl-2 family member BNIP3 regulates cellular proliferation.
The BH3-only family member BNIP3 has been described as either promoting cell survival or cell death. This depends upon the level of BNIP3 expression and its cellular localization. Increased BNIP3 expression under hypoxia contributes to cell death through increased mitochondrial dysfunction. Furtherm...
Main Authors: | Amandeep Singh, Meghan Azad, Miriam D Shymko, Elizabeth S Henson, Sachin Katyal, David D Eisenstat, Spencer B Gibson |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2018-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC6181300?pdf=render |
Similar Items
-
The role of Bid, BH3-only Bcl-2 family member, in cytokine withdrawal-induced apoptosis.
by: LU CHUN TING, et al.
Published: (2001) -
The Role of BNIP3 in Proliferation and Hypoxia-Induced Autophagy: Implications for Cancer Therapy
by: Azad, Meghan Brianne
Published: (2010) -
The Role of BNIP3 in Proliferation and Hypoxia-Induced Autophagy: Implications for Cancer Therapy
by: Azad, Meghan Brianne
Published: (2010) -
The Bcl-2 Homology-3 Domain (BH3)-Only Proteins, Bid, DP5/Hrk, and BNip3L, Are Upregulated in Reactive Astrocytes of End-Stage Mutant SOD1 Mouse Spinal Cord
by: Nathan Duval, et al.
Published: (2018-01-01) -
Structural Investigation of Orf Virus Bcl-2 Homolog ORFV125 Interactions with BH3-Motifs from BH3-Only Proteins Puma and Hrk
by: Chathura D. Suraweera, et al.
Published: (2021-07-01)