Efficacy of intravitreal injection of Ranibizumab combined with macular grid photocoagulation for diabetic macular edema
AIM: To evaluate the efficacy of intravitreal injection of ranibizumab combined with macular grid photocoagulation for diabetic macular edema. <p>METHODS: In this prospective cohort study, total 78 patients(101 eyes)diagnosed with diabetic macular edema in Dongguan People's Hospital from...
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doaj-27abb318896f4316b3025990419367672020-11-25T04:03:29ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232020-12-0120122167216910.3980/j.issn.1672-5123.2020.12.31Efficacy of intravitreal injection of Ranibizumab combined with macular grid photocoagulation for diabetic macular edemaPing-Ping Ma0Li-Yin Liang1Qing-Yang Liu2Jin-Biao Zheng3Department of Ophthalmology, Dongguan People's Hospital, Dongguan 523000, Guangdong Province, ChinaDepartment of Ophthalmology, Dongguan People's Hospital, Dongguan 523000, Guangdong Province, ChinaDepartment of Ophthalmology, Dongguan People's Hospital, Dongguan 523000, Guangdong Province, ChinaDepartment of Ophthalmology, Dongguan People's Hospital, Dongguan 523000, Guangdong Province, ChinaAIM: To evaluate the efficacy of intravitreal injection of ranibizumab combined with macular grid photocoagulation for diabetic macular edema. <p>METHODS: In this prospective cohort study, total 78 patients(101 eyes)diagnosed with diabetic macular edema in Dongguan People's Hospital from October 2016 to December 2018 were randomly divided into two groups. 40 patients(52 eyes)were in combination therapy group and 38 patients(49 eyes)were in monotherapy group. The changes of best corrected visual acuity(BCVA), central retinal thickness(CRT)and frequency of injections in two groups were compared after 12mo follow-up.<p>RESULTS: At the end of 12mo follow up, the BCVA(0.44±0.22 <i>vs</i> 0.55±0.23)and CRT(335.3±65.9μm <i>vs</i> 370.4±84.4μm; <i>P</i><0.05)were better in combination therapy group than that in monotherapy group. Fewer injections were required in combination therapy group compared with that in the monotherapy group(4.04±1.08 <i>vs</i> 5.83±1.92 injections, <i>t</i>= -5.722, <i>P</i><0.05). There was no significant difference between two groups(13.87±2.55 <i>vs</i> 14.04±2.69mmHg, <i>P</i>>0.05)in intraocular pressure. <p>CONCLUSION: Combination therapy of ranibizumab and macular grid photocoagulation was an effective treatment for DME patients, could significantly reduced the frequency of injections, and represent a superior therapeutic approach to DME patients.http://ies.ijo.cn/cn_publish/2020/12/202012031.pdfdiabetic macular edemaranibizumabmacular grid photocoagulation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ping-Ping Ma Li-Yin Liang Qing-Yang Liu Jin-Biao Zheng |
spellingShingle |
Ping-Ping Ma Li-Yin Liang Qing-Yang Liu Jin-Biao Zheng Efficacy of intravitreal injection of Ranibizumab combined with macular grid photocoagulation for diabetic macular edema Guoji Yanke Zazhi diabetic macular edema ranibizumab macular grid photocoagulation |
author_facet |
Ping-Ping Ma Li-Yin Liang Qing-Yang Liu Jin-Biao Zheng |
author_sort |
Ping-Ping Ma |
title |
Efficacy of intravitreal injection of Ranibizumab combined with macular grid photocoagulation for diabetic macular edema |
title_short |
Efficacy of intravitreal injection of Ranibizumab combined with macular grid photocoagulation for diabetic macular edema |
title_full |
Efficacy of intravitreal injection of Ranibizumab combined with macular grid photocoagulation for diabetic macular edema |
title_fullStr |
Efficacy of intravitreal injection of Ranibizumab combined with macular grid photocoagulation for diabetic macular edema |
title_full_unstemmed |
Efficacy of intravitreal injection of Ranibizumab combined with macular grid photocoagulation for diabetic macular edema |
title_sort |
efficacy of intravitreal injection of ranibizumab combined with macular grid photocoagulation for diabetic macular edema |
publisher |
Press of International Journal of Ophthalmology (IJO PRESS) |
series |
Guoji Yanke Zazhi |
issn |
1672-5123 1672-5123 |
publishDate |
2020-12-01 |
description |
AIM: To evaluate the efficacy of intravitreal injection of ranibizumab combined with macular grid photocoagulation for diabetic macular edema. <p>METHODS: In this prospective cohort study, total 78 patients(101 eyes)diagnosed with diabetic macular edema in Dongguan People's Hospital from October 2016 to December 2018 were randomly divided into two groups. 40 patients(52 eyes)were in combination therapy group and 38 patients(49 eyes)were in monotherapy group. The changes of best corrected visual acuity(BCVA), central retinal thickness(CRT)and frequency of injections in two groups were compared after 12mo follow-up.<p>RESULTS: At the end of 12mo follow up, the BCVA(0.44±0.22 <i>vs</i> 0.55±0.23)and CRT(335.3±65.9μm <i>vs</i> 370.4±84.4μm; <i>P</i><0.05)were better in combination therapy group than that in monotherapy group. Fewer injections were required in combination therapy group compared with that in the monotherapy group(4.04±1.08 <i>vs</i> 5.83±1.92 injections, <i>t</i>= -5.722, <i>P</i><0.05). There was no significant difference between two groups(13.87±2.55 <i>vs</i> 14.04±2.69mmHg, <i>P</i>>0.05)in intraocular pressure. <p>CONCLUSION: Combination therapy of ranibizumab and macular grid photocoagulation was an effective treatment for DME patients, could significantly reduced the frequency of injections, and represent a superior therapeutic approach to DME patients. |
topic |
diabetic macular edema ranibizumab macular grid photocoagulation |
url |
http://ies.ijo.cn/cn_publish/2020/12/202012031.pdf |
work_keys_str_mv |
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