Acute toxicity investigation regarding clinical and pathological aspects following repeated oral administration of iron oxide nanoparticles in rats
Iron oxide nanoparticles (IONPS) have potential different applications in nanomedicine. These new applications of IONPS have raised exposure risk of this nanomaterials to humans. Up to now, all aspects of IONPS toxicity are not fully clear following animal’s exposure with these novel compounds. This...
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doaj-27b4b264125c4e0e959e2a76a12ad8cb2020-11-25T03:30:12ZengIranian Society of NanomedicineNanomedicine Research Journal 2476-34892476-71232019-12-014422823310.22034/nmrj.2019.04.00437798Acute toxicity investigation regarding clinical and pathological aspects following repeated oral administration of iron oxide nanoparticles in ratsSaba Talesh0Mohammad Koohi1Ehsan Zayerzadeh2Jalal Hasan3Meisam Shabanian4Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.Department of Food Toxicology, Food Technology and Agricultural Products Research Center, Standard Research Institute, Karaj, IranDepartment of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.Chemistry and Petrochemistry Research Center, Standard Research Institute, Karaj, IranIron oxide nanoparticles (IONPS) have potential different applications in nanomedicine. These new applications of IONPS have raised exposure risk of this nanomaterials to humans. Up to now, all aspects of IONPS toxicity are not fully clear following animal’s exposure with these novel compounds. This study aimed to investigate the acute toxicity effects of IONPS in laboratory animals regarding pathotoxicological analysis and clinical aspects. Twenty four male Wistar rats were randomly chosen, and divided into four groups of six rats each. The first, second, and the third groups received 50, 500, and 5000 mg/kg of IONPS solution orally for five days through gavage, respectively. Animal mortality, clinical sings and body weight were evaluated during the study. Fourteen days after the last administration, rats were euthanized for further investigation for histopathological evaluation. There were no death observed in all groups. High and middle dose of the IONPS caused symptoms like lethargy, ataxia, anorexia, isolation, and respiratory arrhythmia over the period of the study. The subjects of the low dose group showed no signs of toxicity. Specific histopathological complications, like hyaline cast in the kidneys, hyperemia and interstitial thickening in the lungs, hemorrhage in the heart and hepatic degeneration in the liver were observed in high dose group. Thus, it can be concluded that, toxicity of IONPS in rats is dose-dependent. This particular size of IONPS can induce serious pathological abnormalities and clinical symptoms in high dose.http://www.nanomedicine-rj.com/article_37798_2c3c80500390c5e53c66fe3b8a7d5c30.pdfiron oxide nanoparticlesratpathologyclinical signstoxicity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Saba Talesh Mohammad Koohi Ehsan Zayerzadeh Jalal Hasan Meisam Shabanian |
spellingShingle |
Saba Talesh Mohammad Koohi Ehsan Zayerzadeh Jalal Hasan Meisam Shabanian Acute toxicity investigation regarding clinical and pathological aspects following repeated oral administration of iron oxide nanoparticles in rats Nanomedicine Research Journal iron oxide nanoparticles rat pathology clinical signs toxicity |
author_facet |
Saba Talesh Mohammad Koohi Ehsan Zayerzadeh Jalal Hasan Meisam Shabanian |
author_sort |
Saba Talesh |
title |
Acute toxicity investigation regarding clinical and pathological aspects following repeated oral administration of iron oxide nanoparticles in rats |
title_short |
Acute toxicity investigation regarding clinical and pathological aspects following repeated oral administration of iron oxide nanoparticles in rats |
title_full |
Acute toxicity investigation regarding clinical and pathological aspects following repeated oral administration of iron oxide nanoparticles in rats |
title_fullStr |
Acute toxicity investigation regarding clinical and pathological aspects following repeated oral administration of iron oxide nanoparticles in rats |
title_full_unstemmed |
Acute toxicity investigation regarding clinical and pathological aspects following repeated oral administration of iron oxide nanoparticles in rats |
title_sort |
acute toxicity investigation regarding clinical and pathological aspects following repeated oral administration of iron oxide nanoparticles in rats |
publisher |
Iranian Society of Nanomedicine |
series |
Nanomedicine Research Journal |
issn |
2476-3489 2476-7123 |
publishDate |
2019-12-01 |
description |
Iron oxide nanoparticles (IONPS) have potential different applications in nanomedicine. These new applications of IONPS have raised exposure risk of this nanomaterials to humans. Up to now, all aspects of IONPS toxicity are not fully clear following animal’s exposure with these novel compounds. This study aimed to investigate the acute toxicity effects of IONPS in laboratory animals regarding pathotoxicological analysis and clinical aspects. Twenty four male Wistar rats were randomly chosen, and divided into four groups of six rats each. The first, second, and the third groups received 50, 500, and 5000 mg/kg of IONPS solution orally for five days through gavage, respectively. Animal mortality, clinical sings and body weight were evaluated during the study. Fourteen days after the last administration, rats were euthanized for further investigation for histopathological evaluation. There were no death observed in all groups. High and middle dose of the IONPS caused symptoms like lethargy, ataxia, anorexia, isolation, and respiratory arrhythmia over the period of the study. The subjects of the low dose group showed no signs of toxicity. Specific histopathological complications, like hyaline cast in the kidneys, hyperemia and interstitial thickening in the lungs, hemorrhage in the heart and hepatic degeneration in the liver were observed in high dose group. Thus, it can be concluded that, toxicity of IONPS in rats is dose-dependent. This particular size of IONPS can induce serious pathological abnormalities and clinical symptoms in high dose. |
topic |
iron oxide nanoparticles rat pathology clinical signs toxicity |
url |
http://www.nanomedicine-rj.com/article_37798_2c3c80500390c5e53c66fe3b8a7d5c30.pdf |
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