Regulation of bile acid receptor activity
Many receptors can be activated by bile acids (BAs) and their derivatives. These include nuclear receptors farnesoid X receptor (FXR), pregnane X receptor (PXR), and vitamin D receptor (VDR), as well as membrane receptors Takeda G protein receptor 5 (TGR5), sphingosine-1-phosphate receptor 2 (S1PR2)...
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KeAi Communications Co., Ltd.
2018-12-01
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doaj-27b4da267c514e98a0753ee9e1c1b3372021-02-02T06:49:05ZengKeAi Communications Co., Ltd.Liver Research2542-56842018-12-0124180185Regulation of bile acid receptor activityYu-Jui Yvonne Wan0Lili Sheng1Corresponding author.; Department of Medical Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA, USADepartment of Medical Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA, USAMany receptors can be activated by bile acids (BAs) and their derivatives. These include nuclear receptors farnesoid X receptor (FXR), pregnane X receptor (PXR), and vitamin D receptor (VDR), as well as membrane receptors Takeda G protein receptor 5 (TGR5), sphingosine-1-phosphate receptor 2 (S1PR2), and cholinergic receptor muscarinic 2 (CHRM2). All of them are implicated in the development of metabolic and immunological diseases in response to endobiotic and xenobiotic exposure. Because epigenetic regulation is critical for organisms to adapt to constant environmental changes, this review article summarizes epigenetic regulation as well as post-transcriptional modification of bile acid receptors. In addition, the focus of this review is on the liver and digestive tract although these receptors may have effects on other organs. Those regulatory mechanisms are implicated in the disease process and critically important in uncovering innovative strategy for prevention and treatment of metabolic and immunological diseases. Keywords: Bile acid receptor, Farnesoid X receptor (FXR), G protein-coupled bile acid receptor, Takeda G protein receptor 5 (TGR5), Sphingosine-1-phosphate receptor 2 (S1PR2), Acetylation, Methylation, Glycosylationhttp://www.sciencedirect.com/science/article/pii/S2542568418300278 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yu-Jui Yvonne Wan Lili Sheng |
spellingShingle |
Yu-Jui Yvonne Wan Lili Sheng Regulation of bile acid receptor activity Liver Research |
author_facet |
Yu-Jui Yvonne Wan Lili Sheng |
author_sort |
Yu-Jui Yvonne Wan |
title |
Regulation of bile acid receptor activity |
title_short |
Regulation of bile acid receptor activity |
title_full |
Regulation of bile acid receptor activity |
title_fullStr |
Regulation of bile acid receptor activity |
title_full_unstemmed |
Regulation of bile acid receptor activity |
title_sort |
regulation of bile acid receptor activity |
publisher |
KeAi Communications Co., Ltd. |
series |
Liver Research |
issn |
2542-5684 |
publishDate |
2018-12-01 |
description |
Many receptors can be activated by bile acids (BAs) and their derivatives. These include nuclear receptors farnesoid X receptor (FXR), pregnane X receptor (PXR), and vitamin D receptor (VDR), as well as membrane receptors Takeda G protein receptor 5 (TGR5), sphingosine-1-phosphate receptor 2 (S1PR2), and cholinergic receptor muscarinic 2 (CHRM2). All of them are implicated in the development of metabolic and immunological diseases in response to endobiotic and xenobiotic exposure. Because epigenetic regulation is critical for organisms to adapt to constant environmental changes, this review article summarizes epigenetic regulation as well as post-transcriptional modification of bile acid receptors. In addition, the focus of this review is on the liver and digestive tract although these receptors may have effects on other organs. Those regulatory mechanisms are implicated in the disease process and critically important in uncovering innovative strategy for prevention and treatment of metabolic and immunological diseases. Keywords: Bile acid receptor, Farnesoid X receptor (FXR), G protein-coupled bile acid receptor, Takeda G protein receptor 5 (TGR5), Sphingosine-1-phosphate receptor 2 (S1PR2), Acetylation, Methylation, Glycosylation |
url |
http://www.sciencedirect.com/science/article/pii/S2542568418300278 |
work_keys_str_mv |
AT yujuiyvonnewan regulationofbileacidreceptoractivity AT lilisheng regulationofbileacidreceptoractivity |
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