Immunization with cholera toxin B subunit induces high-level protection in the suckling mouse model of cholera.
Cholera toxin (CT) is the primary virulence factor responsible for severe cholera. Vibrio cholerae strains unable to produce CT show severe attenuation of virulence in animals and humans. The pentameric B subunit of CT (CTB) contains the immunodominant epitopes recognized by antibodies that neutrali...
Main Authors: | Gregory A Price, Kim McFann, Randall K Holmes |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3585264?pdf=render |
Similar Items
-
Evaluation of TcpF-A2-CTB chimera and evidence of additive protective efficacy of immunizing with TcpF and CTB in the suckling mouse model of cholera.
by: Gregory A Price, et al.
Published: (2012-01-01) -
Immunobiological Characteristics of Cholera Toxin B-Subunit
by: S. N. Klyueva, et al.
Published: (2012-06-01) -
Cholera Toxin Subunit B as Adjuvant––An Accelerator in Protective Immunity and a Break in Autoimmunity
by: Thomas Stratmann
Published: (2015-07-01) -
Improvement of Technology of Cholera Toxin B-Subunit Production
by: A. V. Komissarov, et al.
Published: (2015-12-01) -
Cholera Toxin B: One Subunit with Many Pharmaceutical Applications
by: Keegan J. Baldauf, et al.
Published: (2015-03-01)