Curcumin sensitizes human gastric cancer cells to 5-fluorouracil through inhibition of the NFκB survival-signaling pathway

Curcumin sensitizes human gastric cancer cells to 5-fluorouracil through inhibition of the NFκB survival-signaling pathway

Yanting Kang,1,2,* Wanle Hu,3,* Encheng Bai,1,2 Hailun Zheng,1 Zhiguo Liu,1 Jianzhang Wu,1 Rong Jin,2 Chengguang Zhao,1 Guang Liang1 1Chemical Biology Research Center, School of Pharmaceutical Sciences, 2Department of Epidemiology, First Affiliated Hospital, 3Department of Coloproctology, Second Af...

Full description

Bibliographic Details
Main Authors:	Kang Y, Hu W, Bai E, Zheng H, Liu Z, Wu J, Jin R, Zhao C, Liang G
Format:	Article
Language:	English
Published:	Dove Medical Press 2016-12-01
Series:	OncoTargets and Therapy
Subjects:	5-FU Curcumin NF-κB Drug resistance Gastric cancer
Online Access:	https://www.dovepress.com/curcumin-sensitizes-human-gastric-cancer-cells-to-5-fluorouracil-throu-peer-reviewed-article-OTT

Similar Items

Inhibition of the NF-κB Signaling Pathway by a Novel Heterocyclic Curcumin Analogue
by: Anna-Maria Katsori, et al.
Published: (2015-01-01)

Liposomal Curcumin Targeting Endometrial Cancer Through the NF-κB Pathway
by: Hanzi Xu, et al.
Published: (2018-07-01)

Curcumin improves prostanoid ratio in diabetic mesenteric arteries associated with cyclooxygenase-2 and NF-κB suppression
by: Patumraj S, et al.
Published: (2010-12-01)

CUL4A promotes cell invasion in gastric cancer by activating the NF-κB signaling pathway
by: Gong Y, et al.
Published: (2017-04-01)

Da0324, an inhibitor of nuclear factor-κB activation, demonstrates selective antitumor activity on human gastric cancer cells
by: Jin R, et al.
Published: (2016-03-01)

Curcumin potentiates the potent antitumor activity of ACNU against glioblastoma by suppressing the PI3K/AKT and NF-κB/COX-2 signaling pathways
by: Zhao J, et al.
Published: (2017-11-01)

The LINC00365/SCGB2A1 (Mammaglobin B) Axis Down-Regulates NF-κB Signaling and Is Associated with the Progression of Gastric Cancer
by: Yan XY, et al.
Published: (2020-01-01)

The decreasing of NFκB level in gingival junctional epithelium of rat exposed to Porphyromonas gingivalis with application of 1% curcumin on gingival sulcus
by: Agung Krismariono
Published: (2015-03-01)

Curcumin Enhances Cytotoxic Effects of Bortezomib in Human Multiple Myeloma H929 Cells: Potential Roles of NF-κB/JNK
by: Qing-Xian Bai, et al.
Published: (2012-04-01)

1-Deoxynojirimycin (DNJ) Ameliorates Indomethacin-Induced Gastric Ulcer in Mice by Affecting NF-kappaB Signaling Pathway
by: Xuehua Piao, et al.
Published: (2018-04-01)

Curcumin attenuates MSU crystal-induced inflammation by inhibiting the degradation of IκBα and blocking mitochondrial damage
by: Baofeng Chen, et al.
Published: (2019-08-01)

BDMC33, A Curcumin Derivative Suppresses Inflammatory Responses in Macrophage-Like Cellular System: Role of Inhibition in NF-κB and MAPK Signaling Pathways
by: Ahmad Syahida, et al.
Published: (2012-03-01)

Triblock Copolymer Nanomicelles Loaded with Curcumin Attenuates Inflammation via Inhibiting the NF-κB Pathway in the Rat Model of Cerebral Ischemia
by: Li F, et al.
Published: (2021-05-01)

Autocrine Growth Hormone-Triggered Curcumin Resistance Abolished by NF-κB Signaling Pathway Dependent on Inflammatory Cytokines and Active Polyamine Catabolic Machinery in MCF-7, MDA-MB-453 and MDA-MB-231 Breast Cancer Cells
by: Ajda Çoker Gürkan, et al.
Published: (2017-11-01)

Curcumin protects radiation-induced liver damage in rats through the NF-κB signaling pathway
by: Wei Li, et al.
Published: (2021-01-01)

The Effects of Curcumin on NF-κB Level and Degree of Liver Fibrosis in Rat Liver Fibrosis
by: Supriono, et al.
Published: (2018-12-01)

Curcumin’s Metabolites, Tetrahydrocurcumin and Octahydrocurcumin, Possess Superior Anti-inflammatory Effects in vivo Through Suppression of TAK1-NF-κB Pathway
by: Zhen-Biao Zhang, et al.
Published: (2018-10-01)

Knockdown of RIPK2 Inhibits Proliferation and Migration, and Induces Apoptosis via the NF-κB Signaling Pathway in Gastric Cancer
by: Qian Yang, et al.
Published: (2021-02-01)

NF-κB in Gastric Cancer Development and Therapy
by: Supattra Chaithongyot, et al.
Published: (2021-07-01)

The G-protein-coupled bile acid receptor Gpbar1 (TGR5) inhibits gastric inflammation through antagonizing NF-kB signaling pathway
by: Cong eGuo, et al.
Published: (2015-12-01)

Anti-inflammatory effects of guggulsterone on murine macrophage by inhibiting LPS-induced inflammatory cytokines in NF-κB signaling pathway
by: Zhang JH, et al.
Published: (2016-06-01)

NF-κB as potential target in the treatment of melanoma
by: Madonna Gabriele, et al.
Published: (2012-03-01)

Protective effect and related mechanisms of curcumin in rat experimental periodontitis
by: Chang-Jie Xiao, et al.
Published: (2018-08-01)

Follicle-stimulating hormone inhibits cervical cancer via NF-κB pathway
by: Shi X, et al.
Published: (2018-11-01)

Dihydromyricetin attenuates inflammation through TLR4/NF-kappaB pathway
by: Jing Nianshui, et al.
Published: (2019-09-01)

Antiviral potential of curcumin
by: Dony Mathew, et al.
Published: (2018-01-01)

Emodin Reverses Gemcitabine Resistance of Pancreatic Cancer Cell Lines Through Inhibition of IKKβ/NF-κB Signaling Pathway
by: Tong H, et al.
Published: (2020-10-01)

miR-135a suppresses migration of gastric cancer cells by targeting TRAF5-mediated NF-κB activation
by: Xie Y, et al.
Published: (2019-02-01)

Mechanisms of NF-κB p65 and strategies for therapeutic manipulation
by: Giridharan S, et al.
Published: (2018-10-01)

CXCL5 Promotes Gastric Cancer via Modulating NF-κB and Wnt/β-catenin Signaling-mediated Inhibition of Tumor Immune
by: LIU Li, et al.
Published: (2020-05-01)

Targeting Cytokine Release Through the Differential Modulation of Nrf2 and NF-κB Pathways by Electrophilic/Non-Electrophilic Compounds
by: Francesca Fagiani, et al.
Published: (2020-08-01)

12-HETE facilitates cell survival by activating the integrin-linked kinase/NF-κB pathway in ovarian cancer
by: Liu Q, et al.
Published: (2018-11-01)

Curcumin Ameliorates Lead-Induced Hepatotoxicity by Suppressing Oxidative Stress and Inflammation, and Modulating Akt/GSK-3β Signaling Pathway
by: Ahlam Alhusaini, et al.
Published: (2019-11-01)

Effect of umbelliferone on adjuvant-induced arthritis in rats by MAPK/NF-κB pathway
by: Ouyang L, et al.
Published: (2019-04-01)

Curcumol enhances cisplatin sensitivity of gastric cancer: involvement of microRNA-7 and the nuclear factor-kappa B/snail family transcriptional repressor 1 axis
by: Hu, Y., et al.
Published: (2022)

The Effect of Curcumin and Tetrahydrocurcumin in Combination with 5-fluorouracil on Esophageal Cancer Cell Lines
by: Pendleton, Emily Grace
Published: (2015)

Sulfasalazine inhibits inflammation and fibrogenesis in pancreas via NF-κB signaling pathway in rats with oxidative stress-induced pancreatic injury
by: Wang YR, et al.
Published: (2016-05-01)

Regulation of Polyamine Metabolism by Curcumin for Cancer Prevention and Therapy
by: Tracy Murray-Stewart, et al.
Published: (2017-12-01)

Typhonium giganteum Lectin Exerts A Pro-Inflammatory Effect on RAW 264.7 via ROS and The NF-κB Signaling Pathway
by: Wei Wang, et al.
Published: (2017-09-01)

SIRT6 overexpression induces apoptosis of nasopharyngeal carcinoma by inhibiting NF-κB signaling
by: Ouyang L, et al.
Published: (2018-11-01)