Effect of Low-Dose Aspirin on Soluble FMS-Like Tyrosine Kinase 1/Placental Growth Factor (sFlt-1/PlGF Ratio) in Pregnancies at High Risk for the Development of Preeclampsia
Background: Soluble FMS-like Tyrosine Kinase 1 (sFlt-1) and placental growth factor (PlGF) have been reported to be highly predictive several weeks before the onset of preeclampsia. Objective: To investigate longitudinal changes of serum levels sFlt-1 and PlGF in pregnant women at high risk for the...
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doaj-27d18e3ad8944471be73db895843d37d2020-11-25T02:01:12ZengMDPI AGJournal of Clinical Medicine2077-03832019-09-0189142910.3390/jcm8091429jcm8091429Effect of Low-Dose Aspirin on Soluble FMS-Like Tyrosine Kinase 1/Placental Growth Factor (sFlt-1/PlGF Ratio) in Pregnancies at High Risk for the Development of PreeclampsiaKaroline Mayer-Pickel0Vassiliki Kolovetsiou-Kreiner1Christina Stern2Julia Münzker3Katharina Eberhard4Slave Trajanoski5Ioana-Claudia Lakovschek6Daniela Ulrich7Bence Csapo8Uwe Lang9Barbara Obermayer-Pietsch10Mila Cervar-Zivkovic11Department of Obstetrics and Gynecology, Division of Obstetrics, Medical University of Graz, A-8036 Graz, AustriaDepartment of Obstetrics and Gynecology, Division of Obstetrics, Medical University of Graz, A-8036 Graz, AustriaDepartment of Obstetrics and Gynecology, Division of Obstetrics, Medical University of Graz, A-8036 Graz, AustriaDepartment of Internal Medicine, Div. of Endocrinology and Diabetology, Endocrinology Lab Platform, Medical University of Graz, A-8036 Graz, AustriaDepartment for Core Facility Computational Bioanalytics, Center for Medical Research (ZMF), Medical University of Graz, A-8036 Graz, AustriaDepartment for Core Facility Computational Bioanalytics, Center for Medical Research (ZMF), Medical University of Graz, A-8036 Graz, AustriaDepartment of Obstetrics and Gynecology, Division of Obstetrics, Medical University of Graz, A-8036 Graz, AustriaDepartment of Obstetrics and Gynecology, Division of Obstetrics, Medical University of Graz, A-8036 Graz, AustriaDepartment of Obstetrics and Gynecology, Division of Obstetrics, Medical University of Graz, A-8036 Graz, AustriaDepartment of Obstetrics and Gynecology, Division of Obstetrics, Medical University of Graz, A-8036 Graz, AustriaDepartment of Internal Medicine, Div. of Endocrinology and Diabetology, Endocrinology Lab Platform, Medical University of Graz, A-8036 Graz, AustriaDepartment of Obstetrics and Gynecology, Division of Obstetrics, Medical University of Graz, A-8036 Graz, AustriaBackground: Soluble FMS-like Tyrosine Kinase 1 (sFlt-1) and placental growth factor (PlGF) have been reported to be highly predictive several weeks before the onset of preeclampsia. Objective: To investigate longitudinal changes of serum levels sFlt-1 and PlGF in pregnant women at high risk for the development of preeclampsia and to reveal an impact of aspirin on maternal serum concentrations of sFlt-1 and PlGF. Methods: This was a prospective longitudinal study in 394 women with various risk factors for the development of preeclampsia (chronic hypertension, antiphospholipid syndrome/APS or systemic lupus erythematosus/SLE, thrombophilia, women with a history of preeclampsia, pathologic first trimester screening for preeclampsia) and 68 healthy women. Serum levels of sFlt-1 and PlGF were measured prospectively at 4-week intervals (from gestational weeks 12 until postpartum). Results: The sFlt-1/PlGF ratio was significantly higher in women with an adverse obstetric outcome compared to women with a normal pregnancy, starting between 20 and 24 weeks of gestation. There was no effect of aspirin on sFlt-1/PlGF ratio in women with chronic hypertension, APS/SLE, thrombophilia and controls. The use of aspirin showed a trend towards an improvement of the sFlt-1/PlGF ratio in women with preeclampsia in a previous pregnancy and a significant effect on the sFlt-1/PlGF ratio in women with a pathologic first trimester screening for preeclampsia. Conclusions: Our findings reveal an impact of aspirin on sFlt-1/PlGF ratio in women with a pathologic first trimester screening for preeclampsia, strongly supporting its prophylactic use.https://www.mdpi.com/2077-0383/8/9/1429adverse pregnancy outcomeaspirinfirst trimester screening for preeclampsiahigh-risk pregnanciespreeclampsiasFlt1/PlGF ratio |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Karoline Mayer-Pickel Vassiliki Kolovetsiou-Kreiner Christina Stern Julia Münzker Katharina Eberhard Slave Trajanoski Ioana-Claudia Lakovschek Daniela Ulrich Bence Csapo Uwe Lang Barbara Obermayer-Pietsch Mila Cervar-Zivkovic |
spellingShingle |
Karoline Mayer-Pickel Vassiliki Kolovetsiou-Kreiner Christina Stern Julia Münzker Katharina Eberhard Slave Trajanoski Ioana-Claudia Lakovschek Daniela Ulrich Bence Csapo Uwe Lang Barbara Obermayer-Pietsch Mila Cervar-Zivkovic Effect of Low-Dose Aspirin on Soluble FMS-Like Tyrosine Kinase 1/Placental Growth Factor (sFlt-1/PlGF Ratio) in Pregnancies at High Risk for the Development of Preeclampsia Journal of Clinical Medicine adverse pregnancy outcome aspirin first trimester screening for preeclampsia high-risk pregnancies preeclampsia sFlt1/PlGF ratio |
author_facet |
Karoline Mayer-Pickel Vassiliki Kolovetsiou-Kreiner Christina Stern Julia Münzker Katharina Eberhard Slave Trajanoski Ioana-Claudia Lakovschek Daniela Ulrich Bence Csapo Uwe Lang Barbara Obermayer-Pietsch Mila Cervar-Zivkovic |
author_sort |
Karoline Mayer-Pickel |
title |
Effect of Low-Dose Aspirin on Soluble FMS-Like Tyrosine Kinase 1/Placental Growth Factor (sFlt-1/PlGF Ratio) in Pregnancies at High Risk for the Development of Preeclampsia |
title_short |
Effect of Low-Dose Aspirin on Soluble FMS-Like Tyrosine Kinase 1/Placental Growth Factor (sFlt-1/PlGF Ratio) in Pregnancies at High Risk for the Development of Preeclampsia |
title_full |
Effect of Low-Dose Aspirin on Soluble FMS-Like Tyrosine Kinase 1/Placental Growth Factor (sFlt-1/PlGF Ratio) in Pregnancies at High Risk for the Development of Preeclampsia |
title_fullStr |
Effect of Low-Dose Aspirin on Soluble FMS-Like Tyrosine Kinase 1/Placental Growth Factor (sFlt-1/PlGF Ratio) in Pregnancies at High Risk for the Development of Preeclampsia |
title_full_unstemmed |
Effect of Low-Dose Aspirin on Soluble FMS-Like Tyrosine Kinase 1/Placental Growth Factor (sFlt-1/PlGF Ratio) in Pregnancies at High Risk for the Development of Preeclampsia |
title_sort |
effect of low-dose aspirin on soluble fms-like tyrosine kinase 1/placental growth factor (sflt-1/plgf ratio) in pregnancies at high risk for the development of preeclampsia |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2019-09-01 |
description |
Background: Soluble FMS-like Tyrosine Kinase 1 (sFlt-1) and placental growth factor (PlGF) have been reported to be highly predictive several weeks before the onset of preeclampsia. Objective: To investigate longitudinal changes of serum levels sFlt-1 and PlGF in pregnant women at high risk for the development of preeclampsia and to reveal an impact of aspirin on maternal serum concentrations of sFlt-1 and PlGF. Methods: This was a prospective longitudinal study in 394 women with various risk factors for the development of preeclampsia (chronic hypertension, antiphospholipid syndrome/APS or systemic lupus erythematosus/SLE, thrombophilia, women with a history of preeclampsia, pathologic first trimester screening for preeclampsia) and 68 healthy women. Serum levels of sFlt-1 and PlGF were measured prospectively at 4-week intervals (from gestational weeks 12 until postpartum). Results: The sFlt-1/PlGF ratio was significantly higher in women with an adverse obstetric outcome compared to women with a normal pregnancy, starting between 20 and 24 weeks of gestation. There was no effect of aspirin on sFlt-1/PlGF ratio in women with chronic hypertension, APS/SLE, thrombophilia and controls. The use of aspirin showed a trend towards an improvement of the sFlt-1/PlGF ratio in women with preeclampsia in a previous pregnancy and a significant effect on the sFlt-1/PlGF ratio in women with a pathologic first trimester screening for preeclampsia. Conclusions: Our findings reveal an impact of aspirin on sFlt-1/PlGF ratio in women with a pathologic first trimester screening for preeclampsia, strongly supporting its prophylactic use. |
topic |
adverse pregnancy outcome aspirin first trimester screening for preeclampsia high-risk pregnancies preeclampsia sFlt1/PlGF ratio |
url |
https://www.mdpi.com/2077-0383/8/9/1429 |
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