Application prospects of research on pathogenesis of primary biliary cirrhosis

Application prospects of research on pathogenesis of primary biliary cirrhosis

Primary biliary cirrhosis (PBC) is an autoimmune liver disease characterized by the destruction of small intrahepatic bile ducts. Incomprehensible and complicated autoreactive responses participate in the development and progression of PBC, which involve various immune cells and inflammatory mediato...

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Main Authors: LU Fangting, LIAN Zhexiong
Format: Article
Language:zho
Published: Editorial Department of Journal of Clinical Hepatology 2015-02-01
Series:Linchuang Gandanbing Zazhi
Subjects:
liver cirrhosis， biliary； immunity， natural； immunization， passive； editorial
Online Access:http://www.lcgdbzz.org/qk_content.asp?id=6257&ClassID=114145746
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spelling doaj-27d4604c6f6344fa8dd366be217f2b0d2020-11-24T23:56:32ZzhoEditorial Department of Journal of Clinical HepatologyLinchuang Gandanbing Zazhi1001-52561001-52562015-02-0131215315610.3969/j.issn.1001-5256.2015.02.001Application prospects of research on pathogenesis of primary biliary cirrhosisLU Fangting0LIAN Zhexiong1Liver Immunology Laboratory, School of Life Sciences, University of Science and Technology of China, Hefei 230026, ChinaLiver Immunology Laboratory, School of Life Sciences, University of Science and Technology of China, Hefei 230026, ChinaPrimary biliary cirrhosis (PBC) is an autoimmune liver disease characterized by the destruction of small intrahepatic bile ducts. Incomprehensible and complicated autoreactive responses participate in the development and progression of PBC, which involve various immune cells and inflammatory mediators. Based on the aspects of innate immunity and adaptive immunity, this article summarizes recent advances in the research on PBC pathogenesis at cellular and molecular levels and evaluates the clinical application of these studies. This article not only gives a feasible direction for researchers and clinicians in this study field, but also provides a theoretical basis for clinical diagnosis and novel therapeutic strategies. http://www.lcgdbzz.org/qk_content.asp?id=6257&ClassID=114145746liver cirrhosis， biliary； immunity， natural； immunization， passive； editorial
collection DOAJ
language zho
format Article
sources DOAJ
author LU Fangting
LIAN Zhexiong
spellingShingle LU Fangting
LIAN Zhexiong
Application prospects of research on pathogenesis of primary biliary cirrhosis
Linchuang Gandanbing Zazhi
liver cirrhosis， biliary； immunity， natural； immunization， passive； editorial
author_facet LU Fangting
LIAN Zhexiong
author_sort LU Fangting
title Application prospects of research on pathogenesis of primary biliary cirrhosis
title_short Application prospects of research on pathogenesis of primary biliary cirrhosis
title_full Application prospects of research on pathogenesis of primary biliary cirrhosis
title_fullStr Application prospects of research on pathogenesis of primary biliary cirrhosis
title_full_unstemmed Application prospects of research on pathogenesis of primary biliary cirrhosis
title_sort application prospects of research on pathogenesis of primary biliary cirrhosis
publisher Editorial Department of Journal of Clinical Hepatology
series Linchuang Gandanbing Zazhi
issn 1001-5256
1001-5256
publishDate 2015-02-01
description Primary biliary cirrhosis (PBC) is an autoimmune liver disease characterized by the destruction of small intrahepatic bile ducts. Incomprehensible and complicated autoreactive responses participate in the development and progression of PBC, which involve various immune cells and inflammatory mediators. Based on the aspects of innate immunity and adaptive immunity, this article summarizes recent advances in the research on PBC pathogenesis at cellular and molecular levels and evaluates the clinical application of these studies. This article not only gives a feasible direction for researchers and clinicians in this study field, but also provides a theoretical basis for clinical diagnosis and novel therapeutic strategies.
topic liver cirrhosis， biliary； immunity， natural； immunization， passive； editorial
url http://www.lcgdbzz.org/qk_content.asp?id=6257&ClassID=114145746
work_keys_str_mv AT lufangting applicationprospectsofresearchonpathogenesisofprimarybiliarycirrhosis
AT lianzhexiong applicationprospectsofresearchonpathogenesisofprimarybiliarycirrhosis
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