TREATMENT OF LOWER URINARY TRACT SYMPTOMS CAUSED BY DOUBLE J STENT WITH SOLIFENACIN AND COMBINATION OF TAMSULOSIN PLUS SOLIFENACIN: A COMPARATIVE STUDY
ABSTRACT: OBJECTIVE: To compare the mean change in international prostate symptom score (IPSS) by combination therapy of Tamsulosin and Solifenacin with Solifenacin alone in treatment of lower urinary tract symptoms (LUTS) caused by double J (DJ) stents. STUDY DESIGN: Randomized control trial PLACE...
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doaj-27dc16bd2c5249a0a56908b419e2fd4f2020-11-25T02:02:54ZengUniversity of FaisalabadJournal of University Medical & Dental College2221-78272310-55422018-12-0194TREATMENT OF LOWER URINARY TRACT SYMPTOMS CAUSED BY DOUBLE J STENT WITH SOLIFENACIN AND COMBINATION OF TAMSULOSIN PLUS SOLIFENACIN: A COMPARATIVE STUDYHanan Noor 0Nauman Khalid 1Muhammad Sohail et al.2Senior Registrar, Department of Urology, Madinah Teaching Hospital, FaisalabadAssistant Professor, Department of Urology, Madinah Teaching Hospital, Faisalabad. Assistant Professor, Department of Urology, Madinah Teaching Hospital, Faisalabad. ABSTRACT: OBJECTIVE: To compare the mean change in international prostate symptom score (IPSS) by combination therapy of Tamsulosin and Solifenacin with Solifenacin alone in treatment of lower urinary tract symptoms (LUTS) caused by double J (DJ) stents. STUDY DESIGN: Randomized control trial PLACE AND DURATION OF STUDY: Urology Department, Madinah Teaching Hospital Faisalabad, from December 2015 to June 2016. METHODOLOGY: Total 170 patients having LUTS after DJ stent insertion were selected for the study. DJ stenting was done in these patients before extra-corporeal shock wave lithotripsy (ESWL), following ureterorenoscopy (URS) and intracorporeal lithotripsy, percutaneous nephrolithotomy (PCNL), ureterolithotomy, pyelolithotomy, pyeloplasty and in patients with obstructive uropathy. All the patients were allocated two different groups. Group A received Tamsulosin 0.4 mg and Solifenacin 5 mg daily & Group B received Solifenacin 5 mg once a day every stda y. The IPSS questionnaire was filled on 1 post-operative day and on 6th post-operative week. Final results were made on 6th post-operative week by comparing the mean change in IPSS in both groups. Independent sample t-test and paired t-test were applied. P-value < 0.05 was taken as significant. RESULT: Mean age was 42.92+7.04 years in Group-A and 43.38+6.67 years in Group-B. Total number of male patients was 58 (68.24%) in Group-A and 52 (61.18%) in Group-B. Female patients in Group-A were 27 (31.76%) and 33 (38.82%) in Group-B. Mean IPSS was 9.01+1.29 in Group-A and 9.10+1.23 in Group-B at baseline (p=0.62). After 6 weeks IPSS was 4.69+0.89 in Group-A and 6.87+1.25 in Group-B (p=0.0001). The mean difference in IPSS after 6 weeks was 4.30+1.49 in Group-A and 2.23+1.13 in Group-B with p value 0.0001 reflecting a significant difference between the two groups. CONCLUSIONS: The mean change in IPSS by combined treatment of Tamsulosin and Solifenacin was significant when compared to Solifenacin alone in treatment of DJ stents related LUTS. http://jumdc.com/index.php/jumdc/article/view/99LUTSDouble J stentIPSS |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hanan Noor Nauman Khalid Muhammad Sohail et al. |
spellingShingle |
Hanan Noor Nauman Khalid Muhammad Sohail et al. TREATMENT OF LOWER URINARY TRACT SYMPTOMS CAUSED BY DOUBLE J STENT WITH SOLIFENACIN AND COMBINATION OF TAMSULOSIN PLUS SOLIFENACIN: A COMPARATIVE STUDY Journal of University Medical & Dental College LUTS Double J stent IPSS |
author_facet |
Hanan Noor Nauman Khalid Muhammad Sohail et al. |
author_sort |
Hanan Noor |
title |
TREATMENT OF LOWER URINARY TRACT SYMPTOMS CAUSED BY DOUBLE J STENT WITH SOLIFENACIN AND COMBINATION OF TAMSULOSIN PLUS SOLIFENACIN: A COMPARATIVE STUDY |
title_short |
TREATMENT OF LOWER URINARY TRACT SYMPTOMS CAUSED BY DOUBLE J STENT WITH SOLIFENACIN AND COMBINATION OF TAMSULOSIN PLUS SOLIFENACIN: A COMPARATIVE STUDY |
title_full |
TREATMENT OF LOWER URINARY TRACT SYMPTOMS CAUSED BY DOUBLE J STENT WITH SOLIFENACIN AND COMBINATION OF TAMSULOSIN PLUS SOLIFENACIN: A COMPARATIVE STUDY |
title_fullStr |
TREATMENT OF LOWER URINARY TRACT SYMPTOMS CAUSED BY DOUBLE J STENT WITH SOLIFENACIN AND COMBINATION OF TAMSULOSIN PLUS SOLIFENACIN: A COMPARATIVE STUDY |
title_full_unstemmed |
TREATMENT OF LOWER URINARY TRACT SYMPTOMS CAUSED BY DOUBLE J STENT WITH SOLIFENACIN AND COMBINATION OF TAMSULOSIN PLUS SOLIFENACIN: A COMPARATIVE STUDY |
title_sort |
treatment of lower urinary tract symptoms caused by double j stent with solifenacin and combination of tamsulosin plus solifenacin: a comparative study |
publisher |
University of Faisalabad |
series |
Journal of University Medical & Dental College |
issn |
2221-7827 2310-5542 |
publishDate |
2018-12-01 |
description |
ABSTRACT:
OBJECTIVE: To compare the mean change in international prostate symptom score (IPSS) by combination therapy of Tamsulosin and Solifenacin with Solifenacin alone in treatment of lower urinary tract symptoms (LUTS) caused by double J (DJ) stents. STUDY DESIGN: Randomized control trial PLACE AND DURATION OF STUDY: Urology Department, Madinah Teaching Hospital Faisalabad, from December 2015 to June 2016. METHODOLOGY: Total 170 patients having LUTS after DJ stent insertion were selected for the study. DJ stenting was done in these patients before extra-corporeal shock wave lithotripsy (ESWL), following ureterorenoscopy (URS) and intracorporeal lithotripsy, percutaneous nephrolithotomy (PCNL), ureterolithotomy, pyelolithotomy, pyeloplasty and in patients with obstructive uropathy. All the patients were allocated two different groups. Group A received Tamsulosin 0.4 mg and Solifenacin 5 mg daily & Group B received Solifenacin 5 mg once a day every stda y. The IPSS questionnaire was filled on 1 post-operative day and on 6th post-operative week. Final results were made on 6th post-operative week by comparing the mean change in IPSS in both groups. Independent sample t-test and paired t-test were applied. P-value < 0.05 was taken as significant. RESULT: Mean age was 42.92+7.04 years in Group-A and 43.38+6.67 years in Group-B. Total number of male patients was 58 (68.24%) in Group-A and 52 (61.18%) in Group-B. Female patients in Group-A were 27 (31.76%) and 33 (38.82%) in Group-B. Mean IPSS was 9.01+1.29 in Group-A and 9.10+1.23 in Group-B at baseline (p=0.62). After 6 weeks IPSS was 4.69+0.89 in Group-A and 6.87+1.25 in Group-B (p=0.0001). The mean difference in IPSS after 6 weeks was 4.30+1.49 in Group-A and 2.23+1.13 in Group-B with p value 0.0001 reflecting a significant difference between the two groups. CONCLUSIONS: The mean change in IPSS by combined treatment of Tamsulosin and Solifenacin was significant when compared to Solifenacin alone in treatment of DJ stents related LUTS.
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topic |
LUTS Double J stent IPSS |
url |
http://jumdc.com/index.php/jumdc/article/view/99 |
work_keys_str_mv |
AT hanannoor treatmentoflowerurinarytractsymptomscausedbydoublejstentwithsolifenacinandcombinationoftamsulosinplussolifenacinacomparativestudy AT naumankhalid treatmentoflowerurinarytractsymptomscausedbydoublejstentwithsolifenacinandcombinationoftamsulosinplussolifenacinacomparativestudy AT muhammadsohailetal treatmentoflowerurinarytractsymptomscausedbydoublejstentwithsolifenacinandcombinationoftamsulosinplussolifenacinacomparativestudy |
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