Modulation of the TGF-β signaling pathway by long noncoding RNA in hepatocellular carcinoma
Abstract Hepatocellular carcinoma (HCC) is a type of liver cancer with poor prognosis. There have been demonstrated to exist many possible mechanisms in HCC tumorigenesis, and recent investigations have provided some promising therapy targets. However, further mechanisms remain to be researched to i...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2020-12-01
|
Series: | Biomarker Research |
Subjects: | |
Online Access: | https://doi.org/10.1186/s40364-020-00252-x |
id |
doaj-27de531e76fe4025ac5d5deb4f19384f |
---|---|
record_format |
Article |
spelling |
doaj-27de531e76fe4025ac5d5deb4f19384f2020-12-06T12:16:51ZengBMCBiomarker Research2050-77712020-12-018111110.1186/s40364-020-00252-xModulation of the TGF-β signaling pathway by long noncoding RNA in hepatocellular carcinomaMengzhen Han0Zhibin Liao1Furong Liu2Xiaoping Chen3Bixiang Zhang4Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyHepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyHepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyHepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyHepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Hepatocellular carcinoma (HCC) is a type of liver cancer with poor prognosis. There have been demonstrated to exist many possible mechanisms in HCC tumorigenesis, and recent investigations have provided some promising therapy targets. However, further mechanisms remain to be researched to improve the therapeutic strategy and diagnosis of HCC. Transforming growth factor-β (TGF-β) is a pleiotropic cytokine which plays critical roles in networks of different cellular processes, and TGF-β signaling has been found to participate in tumor initiation and development of HCC in recent years. Moreover, among the molecules and signaling pathways, researchers paid more attention to lncRNAs (long non-coding RNAs), but the connection between lncRNAs and TGF-βremain poorly understood. In this review, we conclude the malignant procedure which lncRNAs and TGF-β involved in, and summarize the mechanisms of lncRNAs and TGF-βin HCC initiation and development. Furthermore, the interaction between lncRNA and TGF-β are paid more attention, and the potential therapy targets are mentioned.https://doi.org/10.1186/s40364-020-00252-xLong noncoding RNATGF-βHepatocellular carcinomaTherapy target |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mengzhen Han Zhibin Liao Furong Liu Xiaoping Chen Bixiang Zhang |
spellingShingle |
Mengzhen Han Zhibin Liao Furong Liu Xiaoping Chen Bixiang Zhang Modulation of the TGF-β signaling pathway by long noncoding RNA in hepatocellular carcinoma Biomarker Research Long noncoding RNA TGF-β Hepatocellular carcinoma Therapy target |
author_facet |
Mengzhen Han Zhibin Liao Furong Liu Xiaoping Chen Bixiang Zhang |
author_sort |
Mengzhen Han |
title |
Modulation of the TGF-β signaling pathway by long noncoding RNA in hepatocellular carcinoma |
title_short |
Modulation of the TGF-β signaling pathway by long noncoding RNA in hepatocellular carcinoma |
title_full |
Modulation of the TGF-β signaling pathway by long noncoding RNA in hepatocellular carcinoma |
title_fullStr |
Modulation of the TGF-β signaling pathway by long noncoding RNA in hepatocellular carcinoma |
title_full_unstemmed |
Modulation of the TGF-β signaling pathway by long noncoding RNA in hepatocellular carcinoma |
title_sort |
modulation of the tgf-β signaling pathway by long noncoding rna in hepatocellular carcinoma |
publisher |
BMC |
series |
Biomarker Research |
issn |
2050-7771 |
publishDate |
2020-12-01 |
description |
Abstract Hepatocellular carcinoma (HCC) is a type of liver cancer with poor prognosis. There have been demonstrated to exist many possible mechanisms in HCC tumorigenesis, and recent investigations have provided some promising therapy targets. However, further mechanisms remain to be researched to improve the therapeutic strategy and diagnosis of HCC. Transforming growth factor-β (TGF-β) is a pleiotropic cytokine which plays critical roles in networks of different cellular processes, and TGF-β signaling has been found to participate in tumor initiation and development of HCC in recent years. Moreover, among the molecules and signaling pathways, researchers paid more attention to lncRNAs (long non-coding RNAs), but the connection between lncRNAs and TGF-βremain poorly understood. In this review, we conclude the malignant procedure which lncRNAs and TGF-β involved in, and summarize the mechanisms of lncRNAs and TGF-βin HCC initiation and development. Furthermore, the interaction between lncRNA and TGF-β are paid more attention, and the potential therapy targets are mentioned. |
topic |
Long noncoding RNA TGF-β Hepatocellular carcinoma Therapy target |
url |
https://doi.org/10.1186/s40364-020-00252-x |
work_keys_str_mv |
AT mengzhenhan modulationofthetgfbsignalingpathwaybylongnoncodingrnainhepatocellularcarcinoma AT zhibinliao modulationofthetgfbsignalingpathwaybylongnoncodingrnainhepatocellularcarcinoma AT furongliu modulationofthetgfbsignalingpathwaybylongnoncodingrnainhepatocellularcarcinoma AT xiaopingchen modulationofthetgfbsignalingpathwaybylongnoncodingrnainhepatocellularcarcinoma AT bixiangzhang modulationofthetgfbsignalingpathwaybylongnoncodingrnainhepatocellularcarcinoma |
_version_ |
1724399065956876288 |