Teriflunomide Does Not Change Dynamics of Nadph Oxidase Activation and Neuronal Dysfunction During Neuroinflammation

Teriflunomide Does Not Change Dynamics of Nadph Oxidase Activation and Neuronal Dysfunction During Neuroinflammation

The multiple sclerosis therapeutic teriflunomide is known to block the de novo synthesis of pyrimidine in mitochondria by inhibiting the enzyme dihydroorotate-dehydrogenase (DHODH). The metabolic processes of oxidative phosphorylation and glycolysis are further possible downstream targets. In health...

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Bibliographic Details
Main Authors: Ronja Mothes, Carolin Ulbricht, Ruth Leben, Robert Günther, Anja E. Hauser, Helena Radbruch, Raluca Niesner
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Molecular Biosciences
Subjects:
teriflunomide
EAE
oxidative stress
neuronal dysfunction
calcium imaging
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2020.00062/full

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