Case report: Extreme levels of serum S-100B in a patient with chronic subdural hematoma

• Main Authors: Malin Elisabet Persson, Eric Peter Thelin, Bo-Michael eBellander
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2012-12-01
• Series: Frontiers in Neurology
• Subjects: Humans; Neurosurgery; biomarkers; malignant melanoma; S-100B
• Online Access: http://journal.frontiersin.org/Journal/10.3389/fneur.2012.00170/full

The protein S-100B is a biomarker increasingly used within neurosurgery and neurointensive care. As a relatively sensitive, yet unspecific, indicator of CNS pathology, potential sources of error must be clearly understood when interpreting serum S-100B levels. This case report studied the course of a 46-year-old gentleman with a chronic subdural haemorrhage, serum S-100B levels of 22 μg/L and a history of malignant melanoma. Both intra- and extra-cranial sources of S-100B are evaluated and imply an unclear contribution of several sources to the total serum concentration. Potential sources of error when interpreting serum concentrations of S-100B are discussed