Treatment of Carbon Tetrachloride and Phenobarbital-Induced Chronic Liver Failure with Intrasplenic Hepatocyte Transplantation

Treatment of Carbon Tetrachloride and Phenobarbital-Induced Chronic Liver Failure with Intrasplenic Hepatocyte Transplantation

Hepatocyte transplantation (HTx) has been shown to improve the survival of laboratory animals with experimentally induced acute liver failure and to ameliorate the physiologic abnormalities associated with liver-based metabolic deficiencies. However, the role of HTx in the treatment of liver cirrhos...

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Main Authors: Naoya Kobayashi, Masahiro Ito, Junta Nakamura, Jin Cai, James M. Hammel, Ira J. Fox M.D.
Format: Article
Language:English
Published: SAGE Publishing 2000-09-01
Series:Cell Transplantation
Online Access:https://doi.org/10.1177/096368970000900512
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spelling doaj-27f1d494c6df44ad810b73a8bfdba3902020-11-25T02:37:14ZengSAGE PublishingCell Transplantation0963-68971555-38922000-09-01910.1177/096368970000900512Treatment of Carbon Tetrachloride and Phenobarbital-Induced Chronic Liver Failure with Intrasplenic Hepatocyte TransplantationNaoya Kobayashi0Masahiro Ito1Junta Nakamura2Jin Cai3James M. Hammel4Ira J. Fox M.D.5First Department of Surgery, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama, 700-8558, JapanDepartment of Surgery, University of Nebraska Medical Center, Omaha, NE 68198Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198Hepatocyte transplantation (HTx) has been shown to improve the survival of laboratory animals with experimentally induced acute liver failure and to ameliorate the physiologic abnormalities associated with liver-based metabolic deficiencies. However, the role of HTx in the treatment of liver cirrhosis (LC) has not been adequately studied. In order to address this issue, HTx was performed in rats following induction of stable LC using phenobarbital (PhB) and carbon tetrachloride (CCl 4 ). Intrasplenic transplantation of 50 × 10 6 primary hepatocytes could significantly improve liver functions and prolong the survival of rats with irreversible, decompensated LC.https://doi.org/10.1177/096368970000900512
collection DOAJ
language English
format Article
sources DOAJ
author Naoya Kobayashi
Masahiro Ito
Junta Nakamura
Jin Cai
James M. Hammel
Ira J. Fox M.D.
spellingShingle Naoya Kobayashi
Masahiro Ito
Junta Nakamura
Jin Cai
James M. Hammel
Ira J. Fox M.D.
Treatment of Carbon Tetrachloride and Phenobarbital-Induced Chronic Liver Failure with Intrasplenic Hepatocyte Transplantation
Cell Transplantation
author_facet Naoya Kobayashi
Masahiro Ito
Junta Nakamura
Jin Cai
James M. Hammel
Ira J. Fox M.D.
author_sort Naoya Kobayashi
title Treatment of Carbon Tetrachloride and Phenobarbital-Induced Chronic Liver Failure with Intrasplenic Hepatocyte Transplantation
title_short Treatment of Carbon Tetrachloride and Phenobarbital-Induced Chronic Liver Failure with Intrasplenic Hepatocyte Transplantation
title_full Treatment of Carbon Tetrachloride and Phenobarbital-Induced Chronic Liver Failure with Intrasplenic Hepatocyte Transplantation
title_fullStr Treatment of Carbon Tetrachloride and Phenobarbital-Induced Chronic Liver Failure with Intrasplenic Hepatocyte Transplantation
title_full_unstemmed Treatment of Carbon Tetrachloride and Phenobarbital-Induced Chronic Liver Failure with Intrasplenic Hepatocyte Transplantation
title_sort treatment of carbon tetrachloride and phenobarbital-induced chronic liver failure with intrasplenic hepatocyte transplantation
publisher SAGE Publishing
series Cell Transplantation
issn 0963-6897
1555-3892
publishDate 2000-09-01
description Hepatocyte transplantation (HTx) has been shown to improve the survival of laboratory animals with experimentally induced acute liver failure and to ameliorate the physiologic abnormalities associated with liver-based metabolic deficiencies. However, the role of HTx in the treatment of liver cirrhosis (LC) has not been adequately studied. In order to address this issue, HTx was performed in rats following induction of stable LC using phenobarbital (PhB) and carbon tetrachloride (CCl 4 ). Intrasplenic transplantation of 50 × 10 6 primary hepatocytes could significantly improve liver functions and prolong the survival of rats with irreversible, decompensated LC.
url https://doi.org/10.1177/096368970000900512
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AT juntanakamura treatmentofcarbontetrachlorideandphenobarbitalinducedchronicliverfailurewithintrasplenichepatocytetransplantation
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