Reversible RNA Modification N1-methyladenosine (m1A) in mRNA and tRNA

Reversible RNA Modification N1-methyladenosine (m1A) in mRNA and tRNA

More than 100 modifications have been found in RNA. Analogous to epigenetic DNA methylation, epitranscriptomic modifications can be written, read, and erased by a complex network of proteins. Apart from N6-methyladenosine (m6A), N1-methyladenosine (m1A) has been found as a reversible modification in...

Full description

Bibliographic Details
Main Authors: Chi Zhang, Guifang Jia
Format: Article
Language:English
Published: Elsevier 2018-06-01
Series:Genomics, Proteomics & Bioinformatics
Online Access:http://www.sciencedirect.com/science/article/pii/S1672022918301050
id doaj-281974077afb47a080fba30e87455c7c
record_format Article
spelling doaj-281974077afb47a080fba30e87455c7c2020-11-24T23:15:07ZengElsevierGenomics, Proteomics & Bioinformatics1672-02292018-06-01163155161Reversible RNA Modification N1-methyladenosine (m1A) in mRNA and tRNAChi Zhang0Guifang Jia1Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, ChinaCorresponding author.; Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, ChinaMore than 100 modifications have been found in RNA. Analogous to epigenetic DNA methylation, epitranscriptomic modifications can be written, read, and erased by a complex network of proteins. Apart from N6-methyladenosine (m6A), N1-methyladenosine (m1A) has been found as a reversible modification in tRNA and mRNA. m1A occurs at positions 9, 14, and 58 of tRNA, with m1A58 being critical for tRNA stability. Other than the hundreds of m1A sites in mRNA and long non-coding RNA transcripts, transcriptome-wide mapping of m1A also identifies >20 m1A sites in mitochondrial genes. m1A in the coding region of mitochondrial transcripts can inhibit the translation of the corresponding proteins. In this review, we summarize the current understanding of m1A in mRNA and tRNA, covering high-throughput sequencing methods developed for m1A methylome, m1A-related enzymes (writers and erasers), as well as its functions in mRNA and tRNA. Keywords: Epitranscriptome, RNA modification, N1-methyladenosine (m1A), m1A writer, m1A eraserhttp://www.sciencedirect.com/science/article/pii/S1672022918301050
collection DOAJ
language English
format Article
sources DOAJ
author Chi Zhang
Guifang Jia
spellingShingle Chi Zhang
Guifang Jia
Reversible RNA Modification N1-methyladenosine (m1A) in mRNA and tRNA
Genomics, Proteomics & Bioinformatics
author_facet Chi Zhang
Guifang Jia
author_sort Chi Zhang
title Reversible RNA Modification N1-methyladenosine (m1A) in mRNA and tRNA
title_short Reversible RNA Modification N1-methyladenosine (m1A) in mRNA and tRNA
title_full Reversible RNA Modification N1-methyladenosine (m1A) in mRNA and tRNA
title_fullStr Reversible RNA Modification N1-methyladenosine (m1A) in mRNA and tRNA
title_full_unstemmed Reversible RNA Modification N1-methyladenosine (m1A) in mRNA and tRNA
title_sort reversible rna modification n1-methyladenosine (m1a) in mrna and trna
publisher Elsevier
series Genomics, Proteomics & Bioinformatics
issn 1672-0229
publishDate 2018-06-01
description More than 100 modifications have been found in RNA. Analogous to epigenetic DNA methylation, epitranscriptomic modifications can be written, read, and erased by a complex network of proteins. Apart from N6-methyladenosine (m6A), N1-methyladenosine (m1A) has been found as a reversible modification in tRNA and mRNA. m1A occurs at positions 9, 14, and 58 of tRNA, with m1A58 being critical for tRNA stability. Other than the hundreds of m1A sites in mRNA and long non-coding RNA transcripts, transcriptome-wide mapping of m1A also identifies >20 m1A sites in mitochondrial genes. m1A in the coding region of mitochondrial transcripts can inhibit the translation of the corresponding proteins. In this review, we summarize the current understanding of m1A in mRNA and tRNA, covering high-throughput sequencing methods developed for m1A methylome, m1A-related enzymes (writers and erasers), as well as its functions in mRNA and tRNA. Keywords: Epitranscriptome, RNA modification, N1-methyladenosine (m1A), m1A writer, m1A eraser
url http://www.sciencedirect.com/science/article/pii/S1672022918301050
work_keys_str_mv AT chizhang reversiblernamodificationn1methyladenosinem1ainmrnaandtrna
AT guifangjia reversiblernamodificationn1methyladenosinem1ainmrnaandtrna
_version_ 1725592096759349248

Similar Items