Regulation of Murine Natural Killer Cell Commitment
NK cells can derive from the same precursors as B and T cells, however to achieve lineage specificity, several transcription factors need to be activated or annulled. While a few important transcription factors have identified for NK genesis the mechanisms of how this is achieved is far from resolve...
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doaj-281f676e9e5546c2af1295d7194c90d32020-11-25T00:18:39ZengFrontiers Media S.A.Frontiers in Immunology1664-32242013-01-01410.3389/fimmu.2013.0001441116Regulation of Murine Natural Killer Cell CommitmentNicholas D Huntington0Stephen L Nutt1Sebastian eCarotta2Walter & Eliza Hall Institute of Medical ResearchWalter & Eliza Hall Institute of Medical ResearchWalter & Eliza Hall Institute of Medical ResearchNK cells can derive from the same precursors as B and T cells, however to achieve lineage specificity, several transcription factors need to be activated or annulled. While a few important transcription factors have identified for NK genesis the mechanisms of how this is achieved is far from resolved. Adding to the complexity of this, NK cells are found and potentially develop in diverse locations in vivo and it remains to be addressed if a common NK cell precursor seeds diverse niches and how transcription factors may differentially regulate NK cell commitment in distinct microenvironments. Here we will summarise some recent findings in NK cell commitment and discuss how a NK cell transcriptional network might be organised, while addressing some misconceptions and anomalies along the way.http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00014/fullTranscription FactorsdevelopmentNK cellsdifferentiationinnate lymphocytesprepro NK |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nicholas D Huntington Stephen L Nutt Sebastian eCarotta |
spellingShingle |
Nicholas D Huntington Stephen L Nutt Sebastian eCarotta Regulation of Murine Natural Killer Cell Commitment Frontiers in Immunology Transcription Factors development NK cells differentiation innate lymphocytes prepro NK |
author_facet |
Nicholas D Huntington Stephen L Nutt Sebastian eCarotta |
author_sort |
Nicholas D Huntington |
title |
Regulation of Murine Natural Killer Cell Commitment |
title_short |
Regulation of Murine Natural Killer Cell Commitment |
title_full |
Regulation of Murine Natural Killer Cell Commitment |
title_fullStr |
Regulation of Murine Natural Killer Cell Commitment |
title_full_unstemmed |
Regulation of Murine Natural Killer Cell Commitment |
title_sort |
regulation of murine natural killer cell commitment |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2013-01-01 |
description |
NK cells can derive from the same precursors as B and T cells, however to achieve lineage specificity, several transcription factors need to be activated or annulled. While a few important transcription factors have identified for NK genesis the mechanisms of how this is achieved is far from resolved. Adding to the complexity of this, NK cells are found and potentially develop in diverse locations in vivo and it remains to be addressed if a common NK cell precursor seeds diverse niches and how transcription factors may differentially regulate NK cell commitment in distinct microenvironments. Here we will summarise some recent findings in NK cell commitment and discuss how a NK cell transcriptional network might be organised, while addressing some misconceptions and anomalies along the way. |
topic |
Transcription Factors development NK cells differentiation innate lymphocytes prepro NK |
url |
http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00014/full |
work_keys_str_mv |
AT nicholasdhuntington regulationofmurinenaturalkillercellcommitment AT stephenlnutt regulationofmurinenaturalkillercellcommitment AT sebastianecarotta regulationofmurinenaturalkillercellcommitment |
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1725375430900318208 |