Research progress of the effects of mtDNA deletion on the biological behavior of tumor cells
The writer summarizes the biological behavior of Mitochondrial DNA deleted cells (ρ0 cells) of multiple tumor cells to investigate the effects of mitochondrial DNA (mtDNA) deletion on tumor. Apoptosis, growth and invasion ability of tumor cells can be affected by mtDNA deletion. It can also induc...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
Editorial Board of Journal of Hainan Medical University
2017-08-01
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Series: | Journal of Hainan Medical University |
Subjects: | |
Online Access: | http://www.hnykdxxb.com/PDF/201716/39.pdf |
Summary: | The writer summarizes the biological behavior of Mitochondrial DNA deleted cells (ρ0
cells) of multiple tumor cells to investigate the effects of mitochondrial DNA (mtDNA)
deletion on tumor. Apoptosis, growth and invasion ability of tumor cells can be affected by
mtDNA deletion. It can also induce the multidrugresistance phenotype of tumor cells. MtDNA
deletion mainly affects the tumor in two aspects: energy metabolism and intracellular signal
transduction. This study may lead to the development of anti-cancer drugs targeting mtDNA. |
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ISSN: | 1007-1237 1007-1237 |