Application of Arterial Spin Labelling in Detecting Retinal Ischemia
Purpose: Here, we have tried to quantify the chorioretinal blood perfusion in patients who are clinically identified to be suffering from retinal ischemia using arterial spin labelling (ASL) MRI. Method: Four participants, diagnosed with retinal ischemia based on their structural OCT and angiography...
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2017-12-01
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doaj-283a1ad01e6647dbb531d461517ee9a72020-11-24T20:51:45ZengKarger PublishersCase Reports in Ophthalmology1663-26992017-12-018354555710.1159/000485316485316Application of Arterial Spin Labelling in Detecting Retinal IschemiaEhsan VaghefiKevin KauvWilson PanDavid SquirrellPurpose: Here, we have tried to quantify the chorioretinal blood perfusion in patients who are clinically identified to be suffering from retinal ischemia using arterial spin labelling (ASL) MRI. Method: Four participants, diagnosed with retinal ischemia based on their structural OCT and angiography test, were then scanned using anatomical MRI as well as ASL. We optimized MR parameters to maximize resolution and target fixation, blinking, and breathing ques to minimize motion artifacts. Results: Participants had a maximum of ∼50 mL/100 mL/min of blood perfusion, which is below the normal values of ∼200 mL/100 mL/min. It also appeared that thinning of the choroid contributes more to the measured decreased chorioretinal perfusion, compared to slowed arterial filling time. Conclusion: Decreased chorioretinal perfusion is a multifactorial event and has been implicated in several posterior eye pathologies. Based on our current results, it seems that ischemia of the eye could be due to anatomy (tissue volume) and/or functionality (arterial flow).https://www.karger.com/Article/FullText/485316Chorioretinal blood flowChorioretinal ischemiaArterial spin labelling |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ehsan Vaghefi Kevin Kauv Wilson Pan David Squirrell |
spellingShingle |
Ehsan Vaghefi Kevin Kauv Wilson Pan David Squirrell Application of Arterial Spin Labelling in Detecting Retinal Ischemia Case Reports in Ophthalmology Chorioretinal blood flow Chorioretinal ischemia Arterial spin labelling |
author_facet |
Ehsan Vaghefi Kevin Kauv Wilson Pan David Squirrell |
author_sort |
Ehsan Vaghefi |
title |
Application of Arterial Spin Labelling in Detecting Retinal Ischemia |
title_short |
Application of Arterial Spin Labelling in Detecting Retinal Ischemia |
title_full |
Application of Arterial Spin Labelling in Detecting Retinal Ischemia |
title_fullStr |
Application of Arterial Spin Labelling in Detecting Retinal Ischemia |
title_full_unstemmed |
Application of Arterial Spin Labelling in Detecting Retinal Ischemia |
title_sort |
application of arterial spin labelling in detecting retinal ischemia |
publisher |
Karger Publishers |
series |
Case Reports in Ophthalmology |
issn |
1663-2699 |
publishDate |
2017-12-01 |
description |
Purpose: Here, we have tried to quantify the chorioretinal blood perfusion in patients who are clinically identified to be suffering from retinal ischemia using arterial spin labelling (ASL) MRI. Method: Four participants, diagnosed with retinal ischemia based on their structural OCT and angiography test, were then scanned using anatomical MRI as well as ASL. We optimized MR parameters to maximize resolution and target fixation, blinking, and breathing ques to minimize motion artifacts. Results: Participants had a maximum of ∼50 mL/100 mL/min of blood perfusion, which is below the normal values of ∼200 mL/100 mL/min. It also appeared that thinning of the choroid contributes more to the measured decreased chorioretinal perfusion, compared to slowed arterial filling time. Conclusion: Decreased chorioretinal perfusion is a multifactorial event and has been implicated in several posterior eye pathologies. Based on our current results, it seems that ischemia of the eye could be due to anatomy (tissue volume) and/or functionality (arterial flow). |
topic |
Chorioretinal blood flow Chorioretinal ischemia Arterial spin labelling |
url |
https://www.karger.com/Article/FullText/485316 |
work_keys_str_mv |
AT ehsanvaghefi applicationofarterialspinlabellingindetectingretinalischemia AT kevinkauv applicationofarterialspinlabellingindetectingretinalischemia AT wilsonpan applicationofarterialspinlabellingindetectingretinalischemia AT davidsquirrell applicationofarterialspinlabellingindetectingretinalischemia |
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1716801351301726208 |