Heme and hemoglobin utilization by Mycobacterium tuberculosis

Iron is essential for growth of Mycobacterium tuberculosis, but most of the iron in the human body is stored in heme within hemoglobin. Here, Mitra et al. identify two heme uptake mechanisms in M. tuberculosis, one dependent on the inner-membrane Dpp importer and the other dependent on host albumin.

Bibliographic Details
Main Authors:	Avishek Mitra, Ying-Hui Ko, Gino Cingolani, Michael Niederweis
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-12109-5

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spelling	doaj-283f367554ff49d1baa027c6281b5a172021-05-11T11:53:43ZengNature Publishing GroupNature Communications2041-17232019-09-0110111410.1038/s41467-019-12109-5Heme and hemoglobin utilization by Mycobacterium tuberculosisAvishek Mitra0Ying-Hui Ko1Gino Cingolani2Michael Niederweis3Department of Microbiology, University of Alabama at BirminghamDepartment of Biochemistry and Molecular Biology, Thomas Jefferson UniversityDepartment of Biochemistry and Molecular Biology, Thomas Jefferson UniversityDepartment of Microbiology, University of Alabama at BirminghamIron is essential for growth of Mycobacterium tuberculosis, but most of the iron in the human body is stored in heme within hemoglobin. Here, Mitra et al. identify two heme uptake mechanisms in M. tuberculosis, one dependent on the inner-membrane Dpp importer and the other dependent on host albumin.https://doi.org/10.1038/s41467-019-12109-5
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Avishek Mitra Ying-Hui Ko Gino Cingolani Michael Niederweis
spellingShingle	Avishek Mitra Ying-Hui Ko Gino Cingolani Michael Niederweis Heme and hemoglobin utilization by Mycobacterium tuberculosis Nature Communications
author_facet	Avishek Mitra Ying-Hui Ko Gino Cingolani Michael Niederweis
author_sort	Avishek Mitra
title	Heme and hemoglobin utilization by Mycobacterium tuberculosis
title_short	Heme and hemoglobin utilization by Mycobacterium tuberculosis
title_full	Heme and hemoglobin utilization by Mycobacterium tuberculosis
title_fullStr	Heme and hemoglobin utilization by Mycobacterium tuberculosis
title_full_unstemmed	Heme and hemoglobin utilization by Mycobacterium tuberculosis
title_sort	heme and hemoglobin utilization by mycobacterium tuberculosis
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-09-01
description	Iron is essential for growth of Mycobacterium tuberculosis, but most of the iron in the human body is stored in heme within hemoglobin. Here, Mitra et al. identify two heme uptake mechanisms in M. tuberculosis, one dependent on the inner-membrane Dpp importer and the other dependent on host albumin.
url	https://doi.org/10.1038/s41467-019-12109-5
work_keys_str_mv	AT avishekmitra hemeandhemoglobinutilizationbymycobacteriumtuberculosis AT yinghuiko hemeandhemoglobinutilizationbymycobacteriumtuberculosis AT ginocingolani hemeandhemoglobinutilizationbymycobacteriumtuberculosis AT michaelniederweis hemeandhemoglobinutilizationbymycobacteriumtuberculosis
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Heme and hemoglobin utilization by Mycobacterium tuberculosis

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