Heme and hemoglobin utilization by Mycobacterium tuberculosis
Iron is essential for growth of Mycobacterium tuberculosis, but most of the iron in the human body is stored in heme within hemoglobin. Here, Mitra et al. identify two heme uptake mechanisms in M. tuberculosis, one dependent on the inner-membrane Dpp importer and the other dependent on host albumin.
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2019-09-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-12109-5 |
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doaj-283f367554ff49d1baa027c6281b5a172021-05-11T11:53:43ZengNature Publishing GroupNature Communications2041-17232019-09-0110111410.1038/s41467-019-12109-5Heme and hemoglobin utilization by Mycobacterium tuberculosisAvishek Mitra0Ying-Hui Ko1Gino Cingolani2Michael Niederweis3Department of Microbiology, University of Alabama at BirminghamDepartment of Biochemistry and Molecular Biology, Thomas Jefferson UniversityDepartment of Biochemistry and Molecular Biology, Thomas Jefferson UniversityDepartment of Microbiology, University of Alabama at BirminghamIron is essential for growth of Mycobacterium tuberculosis, but most of the iron in the human body is stored in heme within hemoglobin. Here, Mitra et al. identify two heme uptake mechanisms in M. tuberculosis, one dependent on the inner-membrane Dpp importer and the other dependent on host albumin.https://doi.org/10.1038/s41467-019-12109-5 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Avishek Mitra Ying-Hui Ko Gino Cingolani Michael Niederweis |
spellingShingle |
Avishek Mitra Ying-Hui Ko Gino Cingolani Michael Niederweis Heme and hemoglobin utilization by Mycobacterium tuberculosis Nature Communications |
author_facet |
Avishek Mitra Ying-Hui Ko Gino Cingolani Michael Niederweis |
author_sort |
Avishek Mitra |
title |
Heme and hemoglobin utilization by Mycobacterium tuberculosis |
title_short |
Heme and hemoglobin utilization by Mycobacterium tuberculosis |
title_full |
Heme and hemoglobin utilization by Mycobacterium tuberculosis |
title_fullStr |
Heme and hemoglobin utilization by Mycobacterium tuberculosis |
title_full_unstemmed |
Heme and hemoglobin utilization by Mycobacterium tuberculosis |
title_sort |
heme and hemoglobin utilization by mycobacterium tuberculosis |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2019-09-01 |
description |
Iron is essential for growth of Mycobacterium tuberculosis, but most of the iron in the human body is stored in heme within hemoglobin. Here, Mitra et al. identify two heme uptake mechanisms in M. tuberculosis, one dependent on the inner-membrane Dpp importer and the other dependent on host albumin. |
url |
https://doi.org/10.1038/s41467-019-12109-5 |
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1721445710579105792 |